LINTLHA: Ho ba le tsoekere e feteletseng ho etsa hore boko bo tšoanang bo fetohe joaloka ho lemalla lithethefatsi: E kholoanyane D1 e tlamisa, hammoho le ho tlama D2 e tlase
Neuroreport. 2001 Nov 16;12(16):3549-52.
Colantuoni C1, Schwenker J, McCarthy J, Rada P, Ladenheim B, Cadet JL, Schwartz GJ, Moran TH, Hoebel BG.
inahaneloang
Lijo tse ratoang li susumetsa mekhoa e metle ea li-neural e amanang le ho itšetleha ka lithethefatsi; kahoo tsoekere e ka ba le liphello tse kang lithethefatsi tsa tlhekefetso. Li-rats li ile tsa fuoa tharollo ea 25% ea glucose le chow ea 12 h e lateloa ke 12 h ea ho hloka lijo ka letsatsi le leng le le leng. Ba ile ba e-ba le makhetlo a mabeli a li-glucose tse kenang matsatsing a 10 'me ba hlahisa mokhoa oa ho ja haholo ka hora ea pele ea ho fihlella letsatsi ka leng. Ka mor'a matsatsi a 30, ho tlamisoa ha mokotla ho ne ho tšoantšoa le lithibelo tse fepehileng.
Dopamine D-1 receptor binding e eketsehile haholo ho accumbens mantlha le shell. Ka lehlakoreng le leng, ho tlama ha D-2 ho ile ha fokotseha karolong ea dorsal striatum. Ho khomarela dopamine moetapele ho ile ha eketseha har'a li-midbrain. Li-opioid mu-1 li-receptor binding li ile tsa eketseha haholo k'hoteleng ea li-cortex, hippocampus, locus coeruleus le accumbens shell. Ka hona, ho ba le tsoekere e feteletseng, ho tsoekere haholo ho matlafatsa D-1 le li-receptors tsa mu-1 haholo joaloka lithethefatsi tse hlekefetsoang.
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