Lijo le lithethefatsi tsa lithethefatsi: Lintho tse tšoanang le tse fapaneng (2017)

Pharmacology Tlhaho ea Lik'hemik'hale le Boitšoaro

Volume 153, February 2017, Maqephe 182-190

http://dx.doi.org/10.1016/j.pbb.2017.01.001

Lintlha-khōlō Tsa

  • Ho lebeletsoe ho ts'oana ho tšoanang pakeng tsa takatso ea lithethefatsi le lijo.
  • Lithethefatsi tsa tlhekefetso li na le litlamorao tse ngata ho feta lijo.
  • Ho ja lijo tse matlafatsang letsatsi le leng le le leng ha ho khetholloe ka ho lemalla lijo.
  • Ho sebelisa matla a mangata haholo tse nang le mafura a mangata ho hlalosa ho nona haholo.
  • Ho fana ka lijo tse matlafatsang ho tsoa bokhobeng ba lijo ho ka ba kotsi.

inahaneloang

Tlhahlobo ena e lekola melemo ea 'bokhoba ba lijo' joalo ka tlhaloso ea ho ja haholo (ke hore, ho ja ho feta se hlokoang ho boloka boima ba 'mele bo phetseng hantle). E hlalosa ho tšoana ho fapaneng litakatsong tsa lijo le lithethefatsi. Mohlala, maemo a tikoloho a ka tsosa boitšoaro le ho batla lithethefatsi, 'takatso' ke boiphihlelo bo tlalehiloeng hore bo etelletse pele ho ja le ho sebelisa lithethefatsi, 'ho itlopa joala' ho amahanngoa le tšebeliso ea tšebeliso ea lithethefatsi le lithethefatsi, 'me mamello e nang le maemo le e sa hlokahaleng e etsahala lijong le ho noa lithethefatsi. Sena se ka lebelloa, ha lithethefatsi tse lemalloang li kenella lits'ebetsong le lits'ebetsong tse ts'oanang tse fetohileng ho susumetsa le ho laola boits'oaro bo ikhethileng, ho kenyeletsoa le ho ja. Bopaki, leha ho le joalo, bo bontša hore lithethefatsi tsa tlhekefetso li na le litlamorao tse matla ho feta lijo, haholoholo mabapi le litlamorao tsa tsona tsa neuroadaptive tse ba etsang hore ba 'batloe.' Le ha ho itlopa joala ho nahanoa e le mofuta oa boits'oaro, ha se sesosa se seholo sa ho ja haholo, hobane ho itlopa joala ho na le tšoaetso e tlase haholo ho feta botenya. Sebakeng seo, ho etsoa tlhahiso ea hore botenya bo bakoa ke ho sebelisoa hofeta khafetsa ha lijo tse matla haholo. Lijo tse joalo, ka mokhoa o ts'oanang, li khahleha hape (khalori bakeng sa khalori) li fokolisa butle. Ho fokotsa phumaneho ea bona ho ka fokotsa ho ja ka mokhoa o fetelletseng mme ka hona ho fokotsa botenya. Ka mokhoa o ts'oanang, ho susumetsa baetsi ba melao hore lijo tsena li lemalla ba ka ts'ehetsa ketso e joalo. Leha ho le joalo, ho beha molato ho ja ho tlōla tekano ka ho lemalla lijo ho ka ba kotsi, hobane ho beha kotsing ea ho nyenyefatsa ho lemalla lintho tse tebileng, le hobane ho ba le takatso ea ho ja haholo ho lemalla lijo ho bolela ho se khone ho laola ho ja ha motho. Ka hona, ho re ho ja ka ho feteletseng letsatsi le leng le le leng ke lekhoba la lijo ho kanna ha se hlalose kapa hona ho thusa haholo ho fokotsa bothata bona.

Keywords

  • Tlatsetso;
  • Takatso ea lijo;
  • Tlhahiso;
  • Lijo;
  • Lithethefatsi;
  • Moputso;
  • Ho Nona Haholo;
  • Ho lakatsa;
  • Ho itlopa lijo

1. Selelekela

Ts'ebeliso ea mahlale a tlatsetso ea polelo ha e bua ka lijo (chokolete) e qapiloe e le morao ho 1890, e lateloe ke thahasello e potlakileng sehlooho se qalileng ho tsoa li-1950s, le ho tebisoa ha lingoliloeng sebakeng seo haufinyane haholo (Meule, 2015). Patlisiso ena ea morao-rao e akaretsa lithuto tsa boits'oaro le tsa mmele ho batho, le nts'etsopele ea mehlala ea liphoofolo ea 'taolo ea lijo' e fumanang liphumano tse batsi tsa mehlala ea liphoofolo tsa bokhoba ba lithethefatsi. Karolo e kholo ea bohlokoa ba bokhoba ba tahi, ehlile e kotsing ea ts'enyo e etsoang ho batho ba lemalloang, ho malapa a bona le ho ba bang ba amehileng ka tsela e sa tobang, mmoho le moroalo o behiloeng ho bafani ba tsa bophelo bo botle le ba boholong le ba mmuso. Litsenyehelo tsa motho ka mong le moruo tsa ho nona haholo le botenya, ka maemo a tsona a amanang le lefu la tsoekere la 2, lefu la pelo le lefu la masapo a maqhubu le tsona li kholo haholo, li hloka 'ketso e potlakileng ea lefatše' (Ng et al., 2014). Ho hokahanya mathata ana ke monyetla oa hore ho ja haholo (ho hlalosoa e le lijo tse ngata haholo tse hlokoang ho boloka boima ba 'mele) ho ka utloisisoa, bonyane ka karolo, joalo ka bokhoba ba lijo. Morero oa tlhahlobo ena ke ho lekola hore na ho na le ho tšoana hofe pakeng tsa tšebeliso ea lijo le tšebeliso ea lithethefatsi tse lemalloang joalo ka joala, opioids, li-stimulants le koae le hore na papiso ena e ka thusa ho loants'eng lijo tse ngata.

2. Ho lemalla eng?

Potso ena e bohlokoa bakeng sa ho etsa qeto ea hore na boitšoaro bo itseng bo joalo kapa che, bo kang ho ja chokolete kapa ho tsuba koae, bo tšoaneleha ho ba temallo. Haeba, mohlala, ho sebelisitsoe litekanyetso tse thata haholo mohlomong ho ka etsoa qeto ea hore tšebeliso ea lijo e ne e le seoelo kapa e ne e le sieo.

Litekanyetsong tsa bongaka tse boletsoeng li hlahisitsoe ho, ka mohlala, Buka ea Boholo ba Phatlalatso ea Ts'oaetso ea kelello, 5th Edition (DSM-5) (Mokhatlo oa Mahlale oa Amerika, 2013) le Thupelo ea Machabeng ea Maloetse le Mathata a amanang le Bophelo bo Botle (Mokhatlo oa Lefatše oa Bophelo, 1992). Libuka tsena tse peli li lumellane haholo ho thathamisa mekhoa ea bohlokoa e hlalosang bokhoba ba ho ba bonyane tse peli kapa tse tharo tsa tse latelang: mathata a taolo ea ts'ebeliso ea lithethefatsi; takatso e matla kapa ho lakatsa ntho; mamello e joalo e le hore litekanyetso li eketseha tsa ntho li hlokoa ho fihlela tahi kapa litlamorao tse lakatsehang; litlamorao tse tlisoang ke ho tlosoa ke ntho e mpe; ho hlokomoloha lithahasello tse ling, le mesebetsi ea sechaba, lelapa le mesebetsi; liteko tse sa atleheng tsa ho tlohela tšebeliso; mme o tsoelepele ho sebelisoa le ha o e-na le tsebo ea kotsi ea 'mele kapa ea kelello e bakiloeng ke ntho eo. Ha e le hantle, libukeng tsena ka bobeli li qoba ho sebelisa temallo ea polelo, ho e-na le ho khetha 'Mathata a Ts'ebeliso ea Lithethefatsi' le 'ts'ebeliso ea ts'ebeliso ea lithethefatsi.' Ba bang ba thibela tlhekefetso ho 'boemo bo fetelletseng kapa ba psychopathological moo taolo ea ts'ebeliso ea lithethefatsi e lahlehileng,' mme ba khetholla sena ho latela ts'episo eo ba reng 'e bua ka boemo ba ho hloka moriana hore o sebetse ka har'a meeli e tloaelehileng' le eo 'hangata e amanang le mamello le ho iketla, hape ke bokhoba ba ho etsa '(Altman et al., 1996, p 287).

Tlatsetso ho maikutlo a litsebi, litlhaloso tsa dikishinari li fana ka bopaki bo botle haholo ba hore na mantsoe a sebelisoa joang bophelong ba letsatsi le letsatsi. Tlhaloso ea mantlha ea bokhoba ba tlatsetso e ka akaretsoa ka ho ba 'ho phela hantle' meleng le / kapa kelellong ka ntho e itseng kapa ketso e itseng, 'ho its'etleha maemong ana ho hlalosoa e le' ho se khone ho etsa ntle le ho hong. ' E amanang le litlhaloso tsena ke mohopolo oa 'ho qobelloa' le 'ho tebela pele', kapa ho bobebe haholo ho 'rata' kapa 'ho rata' ntho e itseng. Tsena li ka sebetsa ho motho ea itlosang bolutu kapa, ka mohlala, motho ea reng ba 'lemaletse ho shebella lits'oants'o tsa sesepa,' ba fetisa maikutlo a bona bakeng sa mengolo e itseng ea litšoantšiso tsa TV, empa mohlomong hape ba fana ka maikutlo a hore ba ikutloa ba qeta nako ea bona e ngata haholo ho ketsahalo ena. Ka mokhoa o ts'oanang, motho ea ipolelang hore ke 'tsokotsane' a ka 'na a ba le tjantjello ea seo a bonang e le tšebeliso ea bona e feteletseng ea chokolete (Rogers le Smit, 2000). Leha ho le joalo, ho ka ba le khoao e nyane ea hore mehlala ena e supa mathata a fokolang haholo a bakoang ke 'ho lemalla' ho feta a motho ea nang le bothata bo tebileng ba papali ea chelete kapa motho ea nang le bothata ba ho lemalla joala joala joalokaha ho hlalositsoe ho DSM-5.

Sena se supa tlhokahalo ea ho nahana ka kotsi e lekantsoeng ea ho lemalla ho amanang le ho pepesetsoa lintho tse fapaneng le lits'ebetso tse fapaneng, ho fapana le ho beha sehlahisoa joalo ka sekhoba kapa se sa lemalle. Mohlala, bareki ba bangata ba joala ha ba lemale, empa ba bang ba ho etsa. Le ha ho nooa kofi ho le kotsi le ho feta ea ho lemalla, karolo e nyane haholo ea basebelisi ba kasefeine mohlomong e fihlella ka litekanyetso tse thata tsa ts'ebeliso ea lits'ila (lithethefatsi) (Mathata le al., 1994). Hlokomela, leha ho le joalo, e thehiloeng ho Altman et al.'s (1996) Tlhaloso ea ho its'epahalla (kaholimo), boholo ba bareki ba lefatše ba caffeine ba ipapisitse le caffeine (Roger et al., 2013). Mabapi le lijo, senotlolo sa bohlokoa ba moputso se bonahala e le letsoele la matla (likhalori ka boima ba yuniti, Karolo ea 4.3), leha ho le joalo ho na le nyeoe e ngotsoeng hantle ea bokhoba ba lihoete (Kaplan, 1996). Kahoo, ho latela bofokoli le maemo a motho ka mong, mefuta e mengata haholo ea lintho le tšebetso li tlameha ho nkuoa e le tse ka eketsang.

Ka holimo, bokhoba ba litlatsetso bo hlalosoa haholo-holo motheong oa boitšoaro ho isa linthong tse ling le mesebetsing, hammoho le litlaleho tsa mehopolo e amanang, maikutlo le liphihlelo tse ling. Litloaelo le boits'oaro bona bo tla hlahisoa bokong, ho feta moo, ts'ebeliso ea lithethefatsi e ntlafatsa khemikhale ea boko ka mekhoa e ntšetso pele le tšebeliso e mpe ea ts'oaetso (Robinson le Berridge, 1993, Altman et al., 1996 'me Mokhatlo oa Mahlale oa Amerika, 2013). Haholo-holo liphetoho tse hlahisoang ke lithethefatsi tsa tlhaho ka hara ditheo tsa cortical le basal ganglia, tse kenyeletsang mohlala dopaminergic, GABAergic le opioid peptidergic neurocircuitry, ho nahanoa hore li bohlokoa nts'etsopele ea ts'ebeliso ea lithethefatsi tsa lithethefatsi (Everitt le Robbins, 2005 'me Koob le Volkow, 2016). Liphetoho tsena li tšoaea phetoho ho tloha ka tšohanyetso, tšebeliso e mpe ea lithethefatsi ho ea ho tšebeliso ea tloaelo, ho qobelloa le ts'ebeliso e mpe ea khatello, 'me hammoho le khatello e matla, li hlahisa se hlalosoang e le mokoloto o pheta-phetoang oa ho lemalla, o bitsoang' ho itlopa joala kapa ho tahoa, '' hampe e ama 'le' ho nahana / ho lebella (ho lakatsa) '(Koob le Volkow, 2016). Sena ke sa bohlokoa hobane lingoliloeng tse ngata tse lemaletseng lijo li nka hore bokhoba ba lijo bo tšoana le bokhoba ba lithethefatsi (mohlala, Avena et al., 2008, Johnson le Kenny, 2010 'me Gearhardt et al., 2011a) ho fapana le bokhoba ba boits'oaro. Potso e latelang ke hore na lijo le lithethefatsi li na le litlamorao tse kae boits'oarong le bokong?

3. Ho tšoana le phapang ea takatso ea lijo le lithethefatsi

Lethathamo 1 akaretsa lintlha tse ling tse tšoanang ka litabatabelo tsa takatso ea lijo le takatso ea lithethefatsi. Tsena li hlophisitsoe e le litšobotsi tsa boits'oaro, leha ho le joalo moo ho hlokahalang, bopaki le ho ts'ebetso ea motheo ea methapo ea kutlo le bo akaretsitsoe. Lenane ha le bolele ho tšoana, mme moo bo leng teng, phapang lipakeng tsa lijo le lithethefatsi ho litšobotsi li tšohloa.

Tafole 1.

Tse ling li ka tšoana ka litšobotsi tsa takatso ea lijo le lithethefatsi.

Lijo

lithethefatsi

Karolo ea (s)

Taolo ea kantle ea cue ea takatso ea ho ja, ho kenyelletsa takatso e khethehileng ea lijo

Lits'oaetso tse amanang le ho sebelisa lithethefatsi ho etsa hore ba be le takatso e matla ea ho sebelisa lithethefatsi le ho ba le 'tšusumetso e matla'3.1 'me 3.8

Takatso ea lijo e tla le ho ja

Ho hatisa3.2

Tlhahlobo ea thibelo ea lijo

Tlas'a tlolo ea tlheketso3.3

Takatso ea lijo

Takatso ea lithethefatsi3.4

Ho mamella mamello e sitisang 'mele ea ho ja lijo,' ho mamellana ka maikutlo, 'jj.

Ho mamella lithethefatsi3.5

Litlamorao tse tlisoang ke ho khaotsa lijo tse matla

Litlamorao tse tlisoang ke ho khaotsa lithethefatsi3.6

Ho itlopa lijo

Ho itlopa joala ka lithethefatsi3.7, 3.6, 4.1 'me 4.2

Ho rata le ho batla lijo

Ho rata le ho batla lithethefatsi3.8, 3.9 'me 4.3

Moputso khaello ea botona

Khaello ea moputso e hlahisoang ke ho pepesetsoa lithethefatsi3.9

Litlhahlobo tsa lipapali

3.1. Taolo ea ka ntle ea 'nete ea takatso ea lijo le lithethefatsi

Ho thehiloe hantle hore ho pepeseha ponong le monko oa lijo le ho susumetsoa ke takatso ka ntle ho phetoho tse amanang le ho ja, ho eketsa takatso ea ho ja le ho ba le takatso ea boits'oaro (Rogers, 1999). Lintho tsena tse tšoanang li boetse li baka liketsahalo tsa 'mele, ho kenyelletsa ho eketseha ha sesapo, secretion ea gastric acid le tokollo ea insulin (Woods, 1991). Ho a khonahala hore likarabo tsena tsa likarabo ho, bonyane ka karolo, li baka keketseho ea takatso ea lijo, leha karolo ea tsona e kholo e ka hlaha ho lokisa 'mele bakeng sa ho kenella lijo (Karolo ea 3.5). Leha ho le joalo, litlamorao, esita le tsa ho latsoa lijo (Teff, 2011), li nyane haholo ho feta litlamorao tse tšoanang tsa 'mele tse latelang ho kenella. Ho pepesehela mekhoa e amanang le lijo ho boetse ho sebetsa e le sehopotso sa ho ja le monate oa ho ja, 'me ho bonahala eka takatso ea lijo e eketsoa haholo bakeng sa lijo tse lakatsehang ka boeona kapa lijo tse tšoanang, kapa lijo tse amanang le boemo boo (mohlala, UK hangata. lijo-thollo kapa tatso ea lijo tsa hoseng, le li-popcorn ka sinema) (Rogers, 1999 'me Ferriday le Brunstrom, 2011).

Ka mokhoa o ts'oanang, ho na le lingoliloeng tse ngata tse bonts'ang litlamorao tsa litekanyetso tse amanang le lithethefatsi mabapi le boits'oaro le physiology. Litlamorao li kenyelletsa takatso e matla ea lithethefatsi ho basebelisi ba lithethefatsi e hlahisoang ke ts'usumetso e amanang le lithethefatsi, le ho khutlisetsoa ho arabela lithethefatsi ho liphoofolo kamora nako ea ho arabela ka mokhoa o sa matlafatsoang (ho felisoa) hape, ho amanang haholo le ts'ebeliso ea lithethefatsi tsa motho, kamora ho khaotsa nako e telele ntle le ho felisoa (Altman et al., 1996 'me Koob et al., 2014). Ha e le lijo, litheko tsena ke likhopotso tsa tšebeliso ea lithethefatsi, 'me li ka hlahisa likarabo tse tšoanang le tsa lithethefatsi le tsa mmele tse fapaneng le lithethefatsi (Altman et al., 1996). Hape, ka tšebeliso e mpe ea lithethefatsi, basebelisi ba lithethefatsi ba ka natefeloa haholo ke ts'usumetso ea litheko tse amanang le lithethefatsi (Robinson le Berridge, 1993; Karolo ea 3.8). Ho pepeseha, ke tsamaiso kapa ho itaola, ea lithethefatsi tse fokolang ka botsona li ka ba le litlamorao tse matla ho feta litheko tse amanang le lithethefatsi. Sena ke ha e le hantle ke priming, eo ho tla buisanoa ka eona kamora moo (Karolo ea 3.2). Tabeng ea ts'ebeliso ea lithethefatsi, joala, mohlala, melomo ea molomo o fokolang kapa tse 'maloa li kopanya ho pepesehela litekanyetso tsa tatso (ka likhakanyo tsa kantle tsa khang) ka tekanyo ea priming ea moriana.

Ho ka lebelloa hore litlamorao tsa lits'oants'o tse kantle li tla fetoloa ke boemo ba motho ba hona joale ba ho khora (botlalo mabapi le ho ja le botahoa mabapi le ts'ebeliso ea lithethefatsi). Leha ho le joalo, ho hlokomela hore mekhoa e kantle e amanang le ho ja e ka susumetsa ts'ebeliso esita le likhoto le batho ba bonahalang eka ba lutse (Weingarten, 1983 'me Cornell et al., 1989) ha ea lokela ho nkuoa e le bopaki ba hore mekhoa ea kantle ke "ho feta" matšoao a kahare a taolo (cf. Petrovich et al., 2002). Lebaka ke hobane khaello ea ho itjella feela ea ho ja (e leng teko ea ho satiation) hangata e ba teng pele sethoathoa se tlala, hoo qetellong ea lijo ho ka bang le monyetla oa ho ba le 'sebaka sa ho feta' haeba lijo tse ling li le teng. hlahisoa (Roger le Brunstrom, 2016). Lits'ebeletso tsa kantle ho naha tse amanang le lijo li bonts'a monyetla oa ho ja, le bokhoni ba ho boloka limatlafatsi tse fetang litlhoko tsa hang-hang li lumella menyetla e joalo hore e sebelisoe, hape e lumella lijo hore li hlotsoe ntle le litlamorao tse mpe. Sena se fapana le bokhoni bo lekanyelitsoeng ba ho mamella lithethefatsi tse ngata le ho tlosoa hoa lithethefatsi.

3.2. Phello ea appetizer le priming

Poleloana e reng 'appéitit vient en mangeant' (takatso ea lijo e tlisoa ke ho ja) e amohela boiphihlelo ba hore ho qala ho ja lijo tse ratoang lijong ho eketsa tšusumetso ea ho ja. Sena se fupulitsoe ke Yeomans (1996), ea ileng a re ketsahalo eo ke "appetizer athari." Liteko tse mabapi le litoeba li bontša phello e tšoanang e ntle ea karabo ea molomo le lijo, ts'ebetso ea eona e ka ba ho boloka boitšoaro bo 'notletsoe' ho ja, ka ho etsa joalo ho thibela tšitiso ea bona pele ho nako ke ketsahalo e ngoe (Wiepkema, 1971). Ha lijo li ntse li tsoela pele ho fana ka maikutlo a matle, a ka 'nang a kenyelletsa tatso le matšoao a pele a ho kenella (de Araujo et al., 2008), butle-butle e makatsoa ke maikutlo a mabe a hlahisoang ke ho bokella lijo ka mpeng (Rogers, 1999). Mohlala o mong oa priming e amanang le ho ja (takatso ea lijo 'Whetting') ke thuto ka Cornell et al. (1989). Behaviourally bonyane, phello ea appetizer, leha e le nyane haholo, e ts'oana le se boleloang ho lingoliloeng mabapi le ts'ebeliso ea lithethefatsi joalo ka litlamorao, 'me taba ea hore sena se etsahala le ka lijo e hlokometsoe ho lingoliloeng tseo (mohlala, de Wit, 1996). Hona le mosebelisi oa lithethefatsi ea nako e telele ea nako e telele hona joale, ho nka lithethefatsi tse nyane ho eketsa takatso ea lithethefatsi. Mothating ona, taba ea bohlokoa ke ea bohlokoa hobane ho a tlameha ho khutlisetsa ts'ebeliso ea lithethefatsi ka botlalo. Sena se ts'ehetsa mokhoa oa ho khaotsa ka ho felletseng ka khothaletso mananeong a mangata a kalafo ea tlhekefetso ea lithethefatsi.

3.3. Ho ja lijo tse lenngoeng le ts'oaetso e khahlanong le thibelo

Hape ho amehang ho oeleng hape ke ho ja lijo tse thibelang lefu le tšilafalo e amanang le tlhekefetso le boitšoaro bo amanang le lehloa (Baumeister et al., 1994). Lintho tsena li bua ka tšebeliso e sa reroang kapa e kholo ho feta ts'ebeliso e reriloeng, 'me ehlile li hlalositsoe ho latela mehopolo le maikutlo a amehang tlolong ea merero ea ho ila. Ho fetelletseng, esita le litlolo tse nyane li utloahala e le koluoa, e leng moo e nyenyefatsang boiteko bo eketsehileng ba boitaolo. Boitšoaro bona bo bontšoa ke ntho e latelang lethathamong la lijo tse sebelisoang ho sebelisoa hangata: 'Ha ke le lijong, ha ke ja lijo tse sa lumelloang, hangata ke qhekella ebe ke ja lijo tse ling tse phahameng tsa khalori' (Stunkard le Messick, 1985). Ka morao ho mona ke mokhoa oa ho nahana kapa ho se be le o mong: 'Ha e le hantle ke eng, ke butsoitse lijo tsa ka, nka mpa ka tsoela pele ho ja - nka qala ho (ja lijong) hosane.' Ka bobeli mabapi le ho ja le ts'ebeliso ea lithethefatsi khothaletso ke ho lebisa litlatsetso bakeng sa tlolo ea sepheo (ho khutlela morao) maemong a laoloang (mohlala, motho o lebelletsoe ho ja kuku moketjaneng oa letsatsi la tsoalo), ho fapana le lintho tse kahare, tse tsitsitseng joalo ka khaello ea boikemisetso, kapa tahi kapa lefu (Baumeister et al., 1994). Hape ke taba ea hore maikutlo a tlase le khatello ea maikutlo li ka baka tšitiso le ho khutla hape, ka karolo e 'ngoe ka ho tlatsa lisebelisoa tsa boitsebahatso. Lijo tse amanang le ho ja hampe le tse amanang le khatello ea maikutlo ke lintho tse hlahelletseng tekanyong ea lijo. Ho ja disinhibition ke ponelo e matla ea ho ba motenya le botenya haholo (Bryant et al., 2008).

3.4. Ho Rata

Takatso ea lijo le lithethefatsi e hlalosoa e le takatso e matla kapa tšusumetso ea ho ja lijo tse itseng kapa sethethefatsi (Rogers le Smit, 2000 'me West le brown, 2013), 'me joalo ka ho etsa joalo ho bolela boiphihlelo bo amanang le ho ja le tšebeliso ea lithethefatsi. Tekanyo ea ho lakatsa takatso e joalo e ipapisitse le litlaleho tsa boithatelo tsa boithati ba boiphihlelo, le likarabo likala tse lekantsoeng ka lentsoe le nepahetseng. Sena ha se thibele tšebeliso ea litakatso e le mokhoa oa ho hlalosa boitšoaro liphoofolong (mohlala, e kanna ea sebetsoa joalo ka tekanyo ea ho arabela moputso oa lithethefatsi), kapa kannete ho batho, empa bohlokoa ba eona bo amana le tšusumetso ea motho ea ho ja lijo le lithethefatsi ho latela moo litakatso li emelang sesosa sa boits'oaro ba takatso ea lijo le ts'ebeliso, kapa litholoana tsa liteko tsa ho se sebelise. Ehlile ts'ebeliso ea lithethefatsi, joalo ka ho tsuba koae, le ho ja ho ka hlaha ntle le ho etelloa pele ke ho lakatsa (Tiffany, 1995, Altman et al., 1996 'me Rogers le Smit, 2000). Ka 'nete, ho ja ha ho amane haholo le takatso. Ho e-na le hoo, re ka 'na ra re' Ke lapile 'ha re lebelletse lijo, kapa' Ke ne ke lapile 'ha re hlalosa hore na hobaneng re ja lijo tse ngata. Le hona, ke ho fetelletsa litaba, joalo ka batho ba fepehileng ka ho lekana, ho ikemisetsa ho ja ho hlile ho laoloa ke ho ba sieo ha tlala (mpa e felletseng e sitisa takatso ea lijo) ho fapana le khaello ea nako e khuts'oane ea phepelo ea matla ho litho tsa mmele le lisele tsa eona (Roger le Brunstrom, 2016).

Ho lakatsa, leha ho le joalo, ho tlaleheloa lijo tse itseng, ho etsa mohlala, UK le US khafetsa bakeng sa chokolete le lijo tse ling tse nkoang e le 'li-treats.' Boikutlo ke hore lijo tse joalo li lokela ho jeoa ka bongata hobane, leha li le monate, li boetse li nkuoa e le 'mafura,' tse seng kotsi, 'indulgent', jj. (Ke ho re, 'e ntle empa e naelitse'). Ho ja ka thata ho etsa hore u be le menahano e mengata ka lijo le ho ameha ka tebello ea ho e ja. Mehopolo ena le maikutlo a amanang le tsona li ngotsoe joalo ka ho lakatsa, kapa 'moreishness' (ho tloheloa ho lakatsa ho feta) haeba thibelo e etsahala nakong ea ha ho ja e le ho fokotsa ho ja pele ho thibela takatso ea lijo ka botlalo (Rogers le Smit, 2000). Tlhahlobo ena e re hopotsa Tiffany's (1995) tlhahiso ea hore tšebeliso ea lithethefatsi e laoloa haholo ke lits'ebetso tsa othomathiki ntle le ho ba teng ha boiphihlelo ba ho lakatsa ntle le ts'ebeliso ea lithethefatsi e ka thibeloa kapa ea hanyetsoa. Ka hona mehopolo e hanyetsanang mabapi le lijo tse itseng le tšebeliso ea lithethefatsi le liteko tse hlahisang lithibelo tsa ho thibela ho ja kapa ho se felle ka botlalo li bapala karolo e kholo ho hlahiseng takatso ea lijo le lithethefatsi.

3.5. Ho mamella

Mamello ea lithethefatsi ke phokotso ea phello ea lithethefatsi tse bakoang ke ho pepesehela ntho ena khafetsa. Kapa ka ts'ebetso, ke 'phetoho ho le letona ho ts'ebetso ea karabo ea tekanyetso hore litekanyetso tse phahameng (tsa moriana) li hlokoe ho hlahisa sephetho se ts'oanang' (Altman et al., 1996). Ho mamella ho ka ba le moputso le litlamorao tse tlisoang ke lithethefatsi tsa tlhekefetso, 'me e ba teng ka lebaka la liphetoho tse fapaneng, ho kenyelletsa metabolism ea lithethefatsi le ts'ebetso ea li-receptor, le nts'etsopele ea likarabo tse lebelletsoeng (tse ithutoang) tse hanyetsanang le litlamorao tse itseng tsa lithethefatsi (Altman et al., 1996). Ho mamella ho fapana hohle ho lithethefatsi, hape ho fapana ka litlamorao tse fapaneng tsa moriana, ho isa tekanyong ea hore sensitization (keketseho ea kutlo) e ka bang le litlamorao tse itseng (Altman et al., 1996). E le mohlala oa mehla, litlamorao tsa kofi e bontša phapang e mamellanang. Mamello e felletseng kapa e batlang e felletse ea ho tsosa le ho ba le tšusumetso e matla ea koae e etsahala maemong a itekanetseng a ho pepeseha hoa caffeine (2-3 linoelo tsa kofi ka letsatsi). Ka lehlakoreng le leng ho na le mamello e lekanyelitsoeng ea keketseho ea ho thothomela hoa letsoho ho bakoang ke caffeine, le ho se mamelle hofe kapa ho se mamellehe hoa phello ea koloi e potlakisang (kapa mamello) ea caffeine (Roger et al., 2013). Ka kakaretso, ho mamella litlamorao le litla-morao tsa lithethefatsi, ho kenyeletsoa koae, joala le opiates, ho bohlokoa ho qaleng le ho boloka tšebeliso ea lithethefatsi le tlhekefetso (Altman et al., 1996). Ho mamella melemo e tlisoang ke lithethefatsi le hona ho ka eketsa tšebeliso ea matla (Altman et al., 1996 'me West le brown, 2013), empa hangata ha boitšoaro (ke hore, tšebeliso ea lithethefatsi kapa lijo) e ba le moputso o fokolang, ha nako e ntse e tsamaea, karabelo e ka lebelloa ho fokotseha (Roger le Hardman, 2015). Sena se tšohloa ka tlase mona mabapi le 'khaello ea moputso' (Karolo ea 3.9).

Tlhahlobong ea hae e reng, "The Eating Paradox: How We Tolerate Food, ' Woods (1991) e etsa khokahano e hlakileng lipakeng tsa mamello ea lithethefatsi le lijo. O pheha khang ea hore likarabo tse bitsoang (tsa boemo bo phahameng) tsa karabelo ea cephalic ea saliople, secretion ea gastric acid le tokollo ea insulin tse etsahalang ka tebello ea ho ja li thusa ho lokisa mmele bakeng sa phephetso ea mmele ea ho ja lijo. Ka ho etsa joalo, ba thusa ho boloka homeostasis ea 'mele, joalo ka ts'ebetso ea mamello ea lithethefatsi e nang le maemo. Boitsebiso ba likarabo bo fapana lipakeng tsa lijo le tšebeliso ea lithethefatsi, le bonyane ka lijo boholo ba litlamorao tse lebelletsoeng bo nyane ho feta karabelo ea 'mele ea ho ja ka hanong le kamora ho koenya.

Karolo e 'ngoe ea mamello ea lijo ke keketseho ea matla a ka mpeng a amanang le ho ja ka bongata (Geliebter le Hashim, 2001). Sena se ka etsa hore ho be le mamello ea 'satiety,' e ka thusang ho jeoa ha lijo tse kholo ho feta li-binges tse latellanang. Ka mokhoa o ts'oanang, mamello ea boits'oaro e ka ba teng, leha e le hanyane ka hanyane, ho batho ba eketsang boholo ba lijo le / kapa maqhubu a lijo butle butle ha nako e ntse e tsamaea, empa ba etsa joalo ntle le ho itlopa joala. Ka lehlakoreng le leng, ho thibela ho kenella ho ka eketsa kutloisiso ea satiety mme ka lehlakoreng le leng ho thusa ho phehella ho sa sebetse, mohlala, batho ba nang le anorexia nervosa (mofuta o thibelang). Ho bontša sena, salivation ea lijo (empa eseng ho monko o seng oa lijo) 2 h kamora ho ja lijo tsa hoseng ho fumanoe e eketsehile ho batho ba nang le bulimia nervosa mme e fokotsehile ho batho ba nang le anorexia nervosa, ha e bapisoa le taolo. Ha mekhoa ea ho ja e ne e tloahelehile haholo kamora matsatsi a 60 a kalafo e matla ea mokuli, liphapang tsena tsa ho ts'oaroa ke lijo li ile tsa fokotseha haholo (LeGoff et al., 1988). Qetellong, mamello ho litlamorao tse thibelang takatso ea lijo tse matla tsa 'mele (mohlala,' leptin upinzani ') e ka ba sesosa se seng sa tlatsetso ea ho nona ho feta tekano (boima ba' mele) (Roger le Brunstrom, 2016; Karolo ea 3.9).

Ho feto-fetoha ha likarabo tse nang le maemo le tse se nang meeli tšebelisong ea ts'ebeliso ea lijo le lithethefatsi ho boloka homeostasis ea 'mele. Le ha ho le joalo, mamello e boetse e thusa ho eketseha ha tšebeliso ea ts'ebeliso 'me, bonyane ka karolo e ts'oanang le e bakang litlamorao tse bohloko le tse nyarosang tsa ho tlosoa hoa lithethefatsi (Altman et al., 1996). Mamello le ho ikarola ke lintho tse kenyellelitsoeng molemong oa ho lemalla. Ho tlohela ho hlalositsoe karolong e latelang.

3.6. Ho ikhula

Nako e telele ea ho ila boithatelo kapa ho qobelloa ho sebelisa lithethefatsi e ka baka litlamorao, ho kenyeletsa dysphoria, ho tšoenyeha, ho hloka boroko, mokhathala, ho nyekeloa, bohloko ba mesifa, litlamorao le ho tsubella (Mokhatlo oa Mahlale oa Amerika, 2013). Botebo ba litlamorao tsa ho khaotsa ho fapana ka bongata sehlopheng sa lithethefatsi, ka ho itlopa joala le li-opioid tse nang le litlamorao tse mpe. Ho baleha le ho qoba litlamorao tse bohloko tsa ho khaotsa ho bonahala eka li na le karolo ea bohlokoa ho phetseng ts'ebeliso ea lithethefatsi (Altman et al., 1996 'me Koob le Volkow, 2016) hape, mohlala, phekolo ea nicotine e emelang ho fokotsa litlamorao tse amanang le ho tsuba, e eketsa katleho ea ho tlohela ho tsuba (Stead et al., 2012). Hape, ha re sebelisa mohlala oa caffeine hape, bopaki bo supa hore tšebeliso ea koae e susumetsoa haholo ke ho tlohela chelete. Sena se mabapi le ts'ebetso ea tlhokomeliso ea ts'ebetso le ts'ebetso ea kelello (bobeli ba ts'ebetso)Roger et al., 2013), le ho rata ho se rate tatso ea koloi (tee, kofi, jj.) moo ho jelloang kofi (Karolo ea 3.8).

Ka lebaka la hore ho ja hangata ho etsahala ntle le tlhoko ea hang-hang ea phepo (eo ho batho ba bangata ba leng libakeng tse nang le phepo e ngata ea nako e ngata), e ke ke ea lekana le phokotso ea ho tlohela. Leha ho le joalo, ka ho se phele ka botlalo, ho ja ho na le moputso (Roger le Hardman, 2015), ka hona, ho itima lijo kapa ho thibeloa ho bolela ho haelloa ke moputso oa lijo, oo ho leng thata ho o hana le ho o sithabetsa.

Mohlala oa litlamorao tsa ho tlosoa hoa moputso oa lijo ke lintho tse fumanoeng litapole tse fumanehang nako le nako ho fihlela 25% glucose kapa 10% sucrose tharollo (cola le lino tse ling tse bobebe li na le 10% sucrose, 'me lino tse' matla 'li na le glucose ea 10%).Colantuoni et al., 2002 'me Avena et al., 2008). Lithutong tsena, likhoto tse fuoeng phihlello ea tsoekere le lijo tse tloaelehileng tsa likhoto tsa laboratori (chow) bakeng sa letsatsi la 12 ha li bapisoa le lihlopha tse ling tsa likhoto tse fuoeng, mohlala, phihlello e tsoelang pele ea tsoekere le chow, kapa phihlello e tsoelang pele ea phihlello ea chow kapa ea nakoana. feela chow. Ha likhoto li pepesetsoa phihlello ea nakoana, li ile tsa theola boima ba 'mele, empa hamorao tsa khona ho eketsa lijo tseo li li jang ho qoba ho theola boima ba' mele hape (Colantuoni et al., 2002). Ho phehiloe khang hore likhoto tsa glucose-plus-chow-intermittent-access ka mor'a nako li ile tsa tla bontša matšoao a tahi ea tsoekere. Kahoo ba hlalosoa e le 'ho itlopa' ka tsoekere, haholo ha e ne e fumaneha qalong ea nako ea phihlello ea lihora tse 12. Mohlala, ts'oaetso ea tsoekere ka hora ea 3 ea phihlello e eketsehile ho tloha ho 8 ml ka letsatsi la pele la phihlello e kenang ho 30 ml ka letsatsi la 8. Leha ho le joalo, haeba ena e le nts'etsopele ea ho itlopa joala, likhoto le tsona li ne li itšela ka chow, hobane ho ne ho na le keketseho e tšoanang ea ho ja chow (ho tloha ho 2.7 g ka letsatsi la 1 ho isa ho 10.5 g ka letsatsi la 8) (Colantuoni et al., 2002). Le ha ho le joalo, ke ho fetelletsa taba ho bitsa lijo tsa pele tsa scrose tse jeoang kamora ho nyahlatsoa letsatsi le leng le le leng 'ho itlopa lijo,' hobane sena se ka ba ka bang 5% ea matla a letsatsi le letsatsi a kenyang matla (Avena et al., 2008). Mokhoa o mong oa ho hlalosa boitšoaro bona ke hore o emela ho ikamahanya le phallo ea lijo. Ka boiphihlelo bo sa khaotseng ba phihlello ea nako le nako likhoto li khona ho bolela esale pele hore li tla fumaneha 'me sena se nolofalletsa ho mamellana ho se nang phepo le lijo tse se nang' nete lijong tse kholo tsa tsoekere le chow (Karolo ea 3.5).

Ka mokhoa o tsotehang, Avena et al. (2008) fumana ho tšoana pakeng tsa litlamorao tsa ho hula lithethefatsi le litlamorao tsa ho hula phihlello ea tsoekere (mmoho le chow). Moetso ke phello ea ho ikhula ho li-opiate tse bakoang ke tsamaiso ea mohanyetsi oa opiate naloxone, e bakang khatello ea maikutlo joalo ka ha e ngotsoe ke, mohlala, khatello ea maikutlo le khatello ea maikutlo, e lekantsoeng ka tatellano ke teko ea ho sesa e qobelloang le nako e sebelisitsoeng matsohong a bulehileng a maze-maze e phahameng. Kamora naloxone, likhoto tsa phihlello ea tsoekere le chow-access (matsatsi a 21 a ho fihlella) li bonts'itse 'ho hula' ho hobe ka ho fetesisa ho feta lihlopha tse fapaneng tsa taolo, leha sehlopha se ikemetseng sa chow se ne se le lipakeng tsa lihlopha tse fepehileng tsa tsoekere-le-chow le lipapatso tsa libitum (Avena et al., 2008). Liphuputso tse ling letotong lena li hlahisitse li-neuroadaptations tse ling ho arabela tsoekere e kenang le ho fepa ka ho tšoanang ka litlamorao tsa ho pepesetsoa lithethefatsi tsa tlhekefetso. Tsena li kenyelelitse liphetoho tse bonts'a tšebetso ea dopamine ea boko e fetohileng, mohlala, D1 le D2 receptor e tlamang ka har'a dorsal striatum, le ho eketsa li-receptor tsa D1 tse tlamang mokokotlong le khetla ea li-nucleus accumbens (Avena et al., 2008). Ho fumanoe hape hore tokollo ea dopamine ka lebaka la ho noa tsoekere e lula e phahame ho feta matsatsi a 21 a phepo ea tsoekere-plus-chow, ha e bapisoa le ho fokotseha ha karabelo ea dopamine ka nako ho sehlopha sa li-intermittent-chow le lihlopha tse ling tsa taolo (Avena et al., 2008) hoo ho tloaelehile ha mohloekisi a sa khotsofatsoe a lahleheloa ke bocha ba hae.

Bangoli ba phethela ka hore 'Bopaki bo ts'ehetsa khopolo-taba ea hore maemong a mang likhoto li ka fetoha ts'ehetso ea tsoekere' (ke hore, li lemaletse, joalo ka ha ho bontšoa ke sehlooho sa pampiri ea tsona) (Avena et al., 2008, p 20). Sena se a utloahala ho isa boholeng bo fihlellang phihlelong ea ho kenella, le ho se tlisoe ke lijo tse nang le moputso (tsoekere) tlasa maemo a khaello ea lijo khafetsa, tikolohong e sa reroang, e bohlokoa haholo. Ho feta mona, sena se ka supa likarolo tse ling tsa ho itlopa lijo ka mor'a nako (hangata) ea ho beheloa lithibelo tsa lijo (3.5 'me 3.7). Taba ea bohlokoa, leha ho le joalo, litamati tsa tsoekere tse tsoang hanyane le hanyane ha li je haholo ebile ha li boima haholo (Avena et al., 2008). Ka lehlakoreng le leng, batho ba kotsing ea ho ja haholo ba na le phihlello ea lijo tse fumanehang habonolo. Moelelong ona (phihlello e sa thibeloang), lipatlisiso mabapi le liphoofolo li bonts'a phapang e kholo karabelong ea neural ho tsoekere le lithethefatsi. Mohlala, ho lokolloa ha dopamine ka khetla ea khubung ho bokellana ka potlako ka lebaka la tšebeliso ea tsoekere le lijo tse ling tse monate, empa eseng lithethefatsi tse lemalloang, ho kenyeletsa morphine, joala le nikotine. Ho feta moo, likhakanyo tse boletsoeng esale pele tsa lijo tse matlafatsang le lithethefatsi ka mokhoa o ts'oanang li hlohlelletsa tlhahiso ea dopamine ka mokokotlong oa pele oa cortex, empa ke likhakanyo tsa lithethefatsi feela tse nang le tšusumetso ho li-nucleus accumbens (Di Chiara, 2005). Boithuto bo bong bo fumana ho se tšoane hoa mekhoa ea ho thunya ka seleng ka har'a kh'usumetso ea likhoto tse arabelang koae le lijo tsa metsi, tseo ho nahanoang hore li ka hlaha ho neuroadaptation e tlisoang ke ho pepesetsoa lithethefatsi tse sa feleng (Carelli, 2002).

Le ha bohlokoa ba mefuta ea phihlello ea maemo a batho e le ntho e belaetsang, ho na le monyetla oa hore ho fihlella lijo ka botlalo ho nang le lijo tse nang le mafura a mangata le mafura a mangata le tsoekere, ho lebisang keketseho e kholo ea matla le matla a 'mele. . Sena se tšohloa ka tlase ho Karolo ea 3.9.

3.7. Ho itlopa lijo

Ho itlopa joala ho hlalosoa e le 'ho ja, nakong e sa rarolloang (mohlala, nakong efe kapa efe ea hora ea 2), lijo tse ngata li hlile li kholo ho feta seo batho ba bangata ba neng ba ka se ja ka nako e tšoanang tlasa maemo a tšoanang.' hammoho le 'maikutlo a ho hloka taolo ea ho ja lijong nakong ea maqephe.' (Mokhatlo oa Mahlale oa Amerika, 2013). Ho itlopa lijo ke mofuta o mong oa batho ba nang le bulimia mothosa le bothata ba ho ja ka mokhoa o itseng (BED), mme e ka hlaha le ho batho ba nang le bothata ba ho ipolaisa tlala. Ho itlopa joala, ho buang ka tšebeliso ea joala e potlakileng ho isa boingong ba motho, mohlomong ke mohlala o ts'oanang oa tšebeliso ea lithethefatsi, leha phapang e le litlamorao tsa joala ha ho etsoa liqeto le tlhokomelo (mohlala, 'joala myopia') (Gable et al., 2016). Hangata, botaoa bofe kapa bofe ba moriana oa tlhekefetso bo ka tšoana le ho itlopa joala (Koob et al., 2014).

Bakeng sa puisano e teng, leha ho le joalo, bohlokoa ba ho itlopa joala ho eona bo ka phethahatsa mekhoa ea bohlokoa ea ho lemalla ho feta ts'ebeliso e feteletseng, ho qala ka kutloisiso ea tahlehelo ea taolo, empa hape ho kenyelletsa le ho thulana le litšusumetso tse matla tsa ho itlopa lijo, ho ithabisa kapa ho imoloha nakong eo. nako ea ho itlopa lijo, ho mamella (Karolo ea 3.5), le ho tsoela pele ho ja ho sa tsotellehe tsebo ea litlamorao tse sa feleng. Motheong ona, thutong e le 'ngoe 92% ea basali ba fumanoeng ba na le BED ba phethahalitse maemo a DSM-IV a ts'ebeliso ea ts'ebeliso ea lithethefatsi (bokhoba ba tahi), leha e le ka tlase ho halofo ea palo eo (42%) e fihletseng litekanyetso tse thata tsa ho lemallaCassin le von Ranson, 2007).

Le ha ho le joalo, bokhoba ba lijo bo hlalositsoeng ke ho ja ho feta tekano bo ne bo ke ke ba bonahala e le lebaka la lijo tse ngata tse feteletseng tse tlatsetsang ho nona le botenya. Batho ba nang le bothata ba ho ipolaisa tlala, ka mokhoa o hlalosang, ba na le 'mele o tlase,' me ha bulimia mothosa le BED li amahanngoa le botenya le botenya, ho ata ha bona (mohlala, 1-1.5% le basali ba 1.6% ba US (Mokhatlo oa Mahlale oa Amerika, 2013)) e tlaase haholo ho feta ho ata ha botenya (mohlala, hajoale ka 37% ho basali ba US) ka hara palo e le 'ngoe (cf. Epstein le Shaham, 2010 'me Ziauddeen et al., 2012).

3.8. Ho rata le ho batla joalo ka sepheo sa tšebeliso ea lithethefatsi

Thutong ea bona ea ts'usumetso ea bokhoba ba lithethefatsi, Robinson le Berridge (1993) khetholla pakeng tsa ho rata lithethefatsi le ho batla, le Berridge (1996) e fana ka tlhahlobo e tšoanang bakeng sa tšusumetso ea ho ja (moputso oa lijo). Ho rata lithethefatsi ke 'litla-morao tse khahlisang' tsa sethethefatsi mme ho khetholloa ho litlamorao tsa ts'usumetso ea litlamorao tse amanang le lithethefatsi, kapa ho batla. Ho kengoa tšebetsong ha li-neural circry tse amanang le nucleus accumbens ho ipapisitse le 'matla a ho susumetsa' ho fana ka tšusumetso e amanang le moputso ('ho ba etsa hore ba batloe'), mme ka ts'ebeliso e phetoang ea lithethefatsi tse ling sistimi ena ea matlafatsoa. Ka lehlakoreng le leng, ts'ebeliso e phetoang e ka baka ho rata lithethefatsi ho fokotseha. Litholoana tsa ho eketseha ha tlhoko ke ho qobella batho ho batla lithethefatsi le ho li nka, leha ho fokotsoe thabo ea litlamorao. Hoa utloahala hore li-neuroadaptations tse tšoanang li etsa hore motho a je haholo, mohlomong haholo-holo ho ja haholo. Phuputsong ea boits'oaro ba batho, leha ho le joalo, litekanyo tsa ho rata le ho batla li batla li ferekanngoa. Le ha ho le bonolo ho lekola lijo tse ratoang ka ho kopa tlhahlobo ea motho monate oa 'tatso' ea lijo, ho thoeng mehato ea ho batla mohlomong ke mehato ea 'moputso oa lijo' (ke hore, ho rata le ho batla) (Roger le Hardman, 2015). Leha ho le joalo, ho bonahala eka ho rata le ho batla ho ama haholo moputso oa lijo ka hore, ka mohlala, moputso oa lijo empa o sa rate lijo o eketsoa ke ho se je lihora tse ngata. Li-nucleus tsa distinct tse bokellang opioid 'libaka tse chesang' li fumanoe bakeng sa ho rata le ho batla (ho ja lijo tse ngata ntle le ho rata ho eketsehileng) (Peciña le Berridge, 2005), le lipatlisiso tse ling tsa morao-rao li bontšitse ka mokhoa o makatsang hore na tatso le likarolo tsa phepelo ea moputso oa lijo li boetse li tšoaetsoa joang ke tsela tse arohaneng tsa dopamine-signaling pathways (Tellez et al., 2016).

Ho rata lijo, leha ho le joalo, ho ka bonahala ho fapane ka tsela e itseng le ho rata lithethefatsi. Ho rata lijo ke monyaka (karabelo e amang maikutlo kapa ea hedonic) e hlahisoang haholo-holo ke ho kopana ka molomo le tšusumetso ea lijo, athe ho rata lithethefatsi ho bonahala ho supa litlamorao tse hlahisitsoeng kamora ho kenella. Bakeng sa lithethefatsi tse ling, leha ho le joalo, haholo-holo, caffeine, joala le nicotine, tsamaiso e kopanya likarolo tsena ka bobeli tsa ho li rata. Bakeng sa kofi, biri, veine le seno sa whisky, le bakeng sa ba tsubang lisakerete le lisakerete, litlamorao tsa maikutlo a oro ke likarolo tsa bohlokoa tsa monate oa ts'ebeliso, ho fihlela moo ho ka bang le khethollo e kholo lipakeng tsa lihlahisoa le mefuta. Litholoana (tsa maikutlo), ho kenyelletsa bohloko ba caffeine le metsoako e meng ea kofi, phello e tukang ea joala molomong le 'mengoapo' oa 'metso' molaleng, qalong o furalla ebile ha o ratoe, empa ho bonahala o fumana molumo o motle oa hedonic joalo ka ka lebaka la ts'ebeliso ea bona e kopantsoe le litlamorao tsa lithethefatsi tse kenang kamora ho kenella. Sena se bonts'itsoe bakeng sa caffeine, e fumanoeng e tiisa ho rata litatso tse itlhommeng pele ('tee ea litholoana' le maro a litholoana) tse kopantsoeng le ho noa k'hafeine (Yeomans et al., 1998), leha sena se etsahala feela bakeng sa bareki ba caffeine ba hlotsoetsoeng ka botlalo ke caffeine, se bonts'ang ntlafatso e mpe. Ka tsela ena, ho rata ho matlafatsoa ke lithethefatsi bakeng sa litlamorao kapa ka maikutlo a setho sa lithethefatsi 'me koloi ea eona e ka sebetsa e le sepheo se eketsehileng sa tšebeliso, joalo ka ha ho kenyeletsoa monate oa monate oa tsoekere, ka tsoekere kapa tse ling tse tsoekere, ka kofi, tee, jj. le lihlahisoa tsa koae le joala. Ha e amana le ho batla, leha ho le joalo, bohlokoa ba sepheo sena sa tšebeliso ea matla a maikutlo a noo e fokotsehile haholo ho temallo (mohlala, ho Alcohol Use Disorder).

3.9. Moputso khaello

Khaello ea moputso (kapa bofokoli), kapa moputso 'hyposensitivity,' e bua ka mohopolo oa hore moputso oa lithethefatsi le lijo o baka tšebeliso e fetelletseng ea lihlahisoa tsena (Blum et al., 1996, Wang et al., 2001, Johnson le Kenny, 2010 'me Stice le Yokum, 2016). (Hona ha ho tšoane le kutloisiso ea moputso mohopolong oa Gray oa matlafatso ea kutloisiso (Corr, 2008), leha a ka feta. Phapang e le 'ngoe ea kutloelo-bohloko ea moputso e ka' na ea bolela ho ba kotsing ea ho lemalla, empa ho feta mona ho khothalletsoa hore ho pepesetsoa lithethefatsi tse lemalloang le lijo tse itseng ho baka tšebetso ea li-duroamine, haholo-holo ho fokotsa ts'ebetso ea driamine dopamine D2, e fokotsang maikutlo a moputso. Ka lebaka lena, hona ho baka tšebeliso e kholo ea tšebeliso, 'me boemong ba ho pepesetsoa lijo tse matla tse nang le mafura a mangata, li baka ho nona haholo. Ho ts'ehetsa sena Johnson le Kenny (2010) phethela tse latelang ho tsoa lithutong tsa bona tsa litlamorao tsa methapo ea pelo le boits'oaro ba ho fa likhoto 'phihlello' (ke hore, phihlello ea 18-23 h ka letsatsi bakeng sa libeke tse 'maloa) lijong tse joalo:'Nts'etsopele ea botenya ho likhoto tse atolositsoeng tsa haufi-ufi e ne e amana haufi le ho haella ha mosebetsi oa moputso oa boko'(p 636); hape 'Khaello ea moputso litlamong tse boima bo fetang tekano e ka bonts'a ho fokotseha ho hoholo hoa methati ea meputso ea kelello ho hanyetsa ho fetella hoa bona ka lijo tse monate. Hypotsoction e joalo e khothalletsoang ke ho ja e ka thusa ho holisa botona ka ho eketsa tšusumetso ea ho ja moputso o phahameng 'obesogenic' lijo ho qoba kapa ho fokotsa boemo bona ba moputso o seng monate'(p 639).

Bothata bo le bong ka litlhahiso tsena tse ling tse amanang le khaello ea moputso ka lebaka la ho ja ka bongata le botenya ke taba ea hore moputso o fokotsoang o lebisa tšebeliso e ngata ea ts'ebeliso. Ka ho utloahalang, ts'ebeliso e kanna ea lebelloa ho ba e fokotsehile haeba e fumaneha e sa putse hanyane ( Roger le Hardman, 2015), hape ke bopaki bo mabapi le tšebeliso ea lijo litekanyetsong tsa ho ja ka ho fetesisa tsa lijo tse ka ntlheng eo. Likhoto li feto-fetoha le phepelo ea lijo tse nang le mafura a mangata hang hang li eketsa matla a tsona mme ka lebaka leo li nate boima ba 'mele (haholo mafura). Leha ho le joalo, ka libeke tse ngata, matla a ho ja a fokotseha mme sekhahla sa ho nona se fokola. Sena se bontša phello e mpe ea ho nona hoa takatso ea takatso ea takatso ea lijo (ho supa leptin ho kanna ha ameha mona) (Roger le Brunstrom, 2016). Sena se ts'ehetsoa hape ke ho hlokomeloa ha ha lijo tse matla haholo li tlosoa 'me likhoto tse nang le phepo e ngata li khutlisetsoa lijong tse tloaelehileng, li ja haholo ha li bapisoa le likhoto tse laoloang kamehla ho chow, ho fihlela ha e le likhoto tse nonneng pele 'boima bo oela ho lekana le likhoto tsa taolo (Rogers, 1985). Matla ana a ka bonoa ho latela tekanyo pakeng tsa takatso ea takatso ea lijo ka boleng ba moputso (hammoho le phello e fokotsoang ea satiety ka khalori) ea lijo tse matla tse nang le matla le thibelo ea takatso ea lijo e lekanang le litaba tsa mafura a mmele (Roger le Brunstrom, 2016). Ho ipapisitsoe le toloko ena, Johnson le Kenny (2010) liqeto, li ka ngoloa bocha ka tsela ena: Nts'etsopele ea botona bo phahameng ho litoeba tse atolositsoeng e ne e amana haufi le ts'ebetso ea moputso oa boko e fokolitsoeng; le moputso o fokotsehileng ho likhoto tse boima haholo li ka bonts'a ho fokotseha hoa bohlokoa ha methapo ea meputso ea boko ho hanyetsa ho tsosoa ha bona ke lijo tse monate. Hypotsoction e joalo e khothalletsoang ke botenya e ka hanyetsa nts'etsopele ea botena ka ho fokotsa ts'usumetso ea ho ja. Sephetho se seng hape sa ho khahlisoa ke ntlafatso ena ke hore ho Johnson le Kenny (2010) ho ithuta khaello ea moputso, joalo ka ha e lekantsoe ke ho eketseha ha monyako oa moputso oa boikhopotso (li-electrodes tse kentsoeng ho hypothalamus ea morao-rao), ho phehella matsatsi a mangata ho feta ho tlosoa ha lijo tse matla tse nang le matla, ho fapana le litlamorao tse fumanoeng litekong tse tšoanang tsa ho tlosoa ha heroin , koae le nikotine (Epstein le Shaham, 2010). Sebakeng sa ho ba le phello e tobileng ea ho tlosoa ha lijo tse matla, phepelo ea khaello ea moputso litulong tsa litheko tsa lijo e tsamaisana le phokotso ea butle ea boima ba liphoofolo tsena (Rogers, 1985).

Ka kakaretso, bopaki bo mabapi le khaello ea moputso e le mokhoa oa ho hlalosa ho ja haholo le botenya bo kopantsoe haholo. Sena se kenyelletsa bopaki bo tsoang lithutong tsa neuroimaging (Ziauddeen et al., 2012 'me Stice le Yokum, 2016), le lithuto tsa boits'oaro. Mohlala oa morao-rao ke thuto e sebelisang mokhoa oa ho fokotsa matla oa "tyrosine / phenylalanine" ho fokotsa ts'ebetso ea dopamine ea boko ho batho ba nkang karolo, e leng se fapaneng le moputso o fumanoeng, haeba ho na le letho, lebaka leo la ho fokolisa takatso le takatso ea lijo (Hardman et al., 2012). Ho feta moo, lithuto tse tla ba teng tsa monahano li na le ho fumana hore karabelo e tlase ho moputso oa lijo e hakanya ho nona ha boima nakong e tlang. Ho ipapisitse le sena, le bopaki bo tsoang mefuteng e meng e mengata ea lithuto, Stice and Yokum (2016), phethela ka hore 'datha e teng e fana ka ts'ehetso e fokolang feela bakeng sa mohopolo oa tlhaelo ea moputso,' empa e le hore ho na le 'ts'ehetso e matla bakeng sa mohopolo oa tšusumetso ea ho fokola' (p 447). Ka mokhoa o ts'oanang, tlhahiso ea hore phapang e le 'ngoe ea ho lemalla lithethefatsi ka lebaka la khaello ea moputso e amana le phapang ea dopamine D2 receptor function (Blum et al., 1990 'me Blum et al., 1996) e hlahisitsoe ka mor'a moo. Ka ts'ehetso, ho na le bopaki bo bonts'ang hore, mohlala, fokotsehile ea DopNUMX e fokotsehileng e eketsa tlokotsi ea ts'ebeliso e mpe ea koae, mme le eona ke phello ea ho pepesehela k'hok'heine, eo ka nako e 'ngoe e kenyang tlhokomelo ea ts'ebeliso ea lithethefatsi (Nader le Czoty, 2005). Ka lehlakoreng le leng, mokhatlo oa dopamine D2 receptor gene Taq1A polymorphism le joala, qalong bo tlalehiloe ke Blum et al. (1990), ha e-so tiisoe (Munafò et al., 2007). Ho bonahala hape ho hlakile hore ha ho na kamano e nang le morero lipakeng tsa polymorphism ena le mafura a motho (Hardman et al., 2014).

4. Puisano

Tlhahlobo e kaholimo e bonts'a hore ho na le pharalla e kholo mekhoeng ea boits'oaro le mekhoeng ea boko e kenyelletsang lijong le ho tse sebelisoang ke ts'ebeliso e mpe ea lithethefatsi le tlhekefetso. Phapang e boetse e bonahala, ka mohlala ka sebopeho le lintlha tsa ho mamella le ho tlohela, leha ho le joalo ka mabaka ana ho tla ba le phapang lipapaling tsa lithethefatsi. Joalokaha ho hlokomeloa khafetsa, lijo le lithethefatsi li fapana hobane ho ja hoa hlokahala bakeng sa ho phela le ts'ebeliso ea lithethefatsi ha se (mohlala ,. Epstein le Shaham, 2010 'me Ziauddeen et al., 2012), empa lijo tse phetseng hantle ha lia lokela ho kenyelletsa lijo tse matla haholo (Epstein le Shaham, 2010) - ehlile motho o na le phepo e ntle haeba lijo tse joalo li qojoa haholo.

Ho joalo, ho ka lebelloa ho tšoana ho teng lipakeng tsa tšusumetso ea ho fumana le ho ja lijo le lithethefatsi tse tlatsetsang, kaha lithethefatsi tsena li kenella lits'ebetsong le lits'ebetsong tse tšoanang tse ileng tsa susumetsa le ho laola boits'oaro bo khahlisang, ho kenyelletsa ho ja (Ziauddeen et al., 2012 'me Salamone le Correa, 2013). Moelelo o matla ke hore lintho tse itseng li "utsoa" mekhoa ena e laoloang e ka etsang boitšoaro bo bobe le likotsi, hobane li na le litlamorao tse ngata tse ntle le tse nchafatsang. Beha ka mokhoa o hlakileng, "Litsela tsa boko tse ileng tsa fetoha ho arabela meputsong ea tlhaho le tsona li hlahisoa ke lithethefatsi tse lemalloang" (Avena et al., 2008, p 20). Le ha ho le joalo, taba ea hore litloaelo tse amanang le lijo le ho ja li kenya lits'ebetso tsena ka boyona hase bopaki ba bokhoba ba lijo. Karolong e kholo sehlopha seo se theohela ho se tšoanelehang e le bokhoba le lithethefatsi tse fapaneng le lijo tse fapaneng ho baka litlamorao.

4.1. Ho feta taba ea litlhaloso

Sesebelisoa se sebelisitsoeng haholo lipatlisisong mabapi le ts'ebeliso ea lithethefatsi tsa lijo ke Yale Food Addiction Scale (YFAS; Gearhardt et al., 2009). Ke sekala sa ho itlaleha (ke hore, ha se tlhahlobo ea tlhahlobo ea maikutlo) e nang le lintho tse 25 tse amanang le 'matšoao' a fapaneng a bokhoba, ho kenyeletsoa le mathata a ho laola tšebeliso ea lithethefatsi (mohlala, 'Ke fumana hore ha ke qala ho ja lijo tse itseng, ke qetella ke ja haholo ho feta kamoo ho neng ho reriloe '), litlamorao tse mpe tsa ho hula (mohlala,' Ke bile le matšoao a ho khaotsa ho tsuba joalo ho tšoenyeha, kapa matšoao a mang a mmele ha ke khaola kapa ke khaotsa ho ja lijo tse itseng '), mamello (mohlala,' Over Nako, ke fumane hore ke hloka ho ja haholoanyane ho fumana maikutlo ao ke a batlang, joalo ka ho fokotsa maikutlo a mabe kapa ho eketsa thabo '), le takatso e phehellang ea ho tlohela, e bolelang boiteko bo sa atleheng ba ho tlohela (mohlala,' ke lekile ho fokotsa kapa o khaotse ho ja mefuta e itseng ea lijo '). Poleloana 'lijo tse itseng' e hlalosetsoa ba arabileng qalong ea lenane la lipotso ka tsela e latelang: 'Batho ka linako tse ling ba na le bothata ba ho laola ho ja ha bona lijo tse ling tse kang,' e lateloa ke lethathamo la lijo tse arotsoeng ka lipompong, setache, seneke tse letsoai, mafura lijo le lino tse tsoekere. Mekhoa ea 'ts'ebeliso ea lithethefatsi' (bokhoba ba tahi) ke palo ea matšoao a ≥ 3 ho tsoa ho 7 e phahameng, hammoho le tumello ea e 'ngoe kapa tse peli tsa' bohlokoa ba kliniki '(mohlala,' Boitšoaro ba ka mabapi le lijo le ho ja bo baka khatello e kholo '). Ho boetse ho fanoa ka mokhoa oa ho bala lintlha tse tsoelang pele tse fanang ka palo ea matšoao 'ntle le ho hlahlojoa' (ea ho itšetleha ka lintho tse itseng).

Kameho le YFAS ke hore e bonahala e akaretsa haholo ho abela mekhoa e itseng ea ho ja le ho ja e le bopaki ba tahi ea lijo. Mohlala, tse ling tsa lijo tse thathamisitsoeng (mohlala, bohobe, bijoux le raese) ke lijo tse tloaelehileng lefatšeng ka bophara, 'me le ha lijo tse joalo li ka hlaha ho ja lijana, khopolo ea letsatsi le letsatsi ea hore ho ka ba thata ho fokotsa ho ja lijo tsena. e hole le 'boemo bo fetisisang ba kelello' boo bafuputsi ba bang ba bo nkang e le letšoao la bokhoba ba tahi (Altman et al., 1996; Karolo ea 2). Ho fumana hore lintlha tsa YFAS li phahame ho batho ba nang le BED (e hlahlojoe ke Nako e telele le al., 2015) ha e netefatse YFAS joalo ka tekanyo ea bokhoba ba lijo, hobane batho ba bangata ba sa utloeng bohloko le BED le bona ba fihlela mokhoa oa YFAS oa ho lemalla lijo. Ebile ha e fumanoe ka litlhaloso tsa neural tsa lintlha tsa YFAS (Gearhardt et al., 2011b) theha YFAS e le tekanyo ea bokhoba ba lijo. Lipalo tsa YFAS li hokahane le ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso e fumanoang ke rasiti e lebelletsoeng ea lijo (chisi ea li-chocolate tsa tsokolate). Sena se kenyelelitse ts'ebetso e kholo ho anterior cingrate cortex, medial orbitofrontal cortex, amygdala le dorsolateral preortal cortex. Le ha litholoana tsena li tšoana le mekhoa ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea boko e fumanoeng bakeng sa ho pepesetsoa litheko tsa lithethefatsi, likarabo tsena ka botsona ha li iphathatse ho lemalla. Ka bokhutšoanyane, ba bonts'a, ka mohlala, ho hohela le ho hanyetsa ho chesa joala ba chokolete ho batho ba nang le liso tse phahameng tsa YFAS.

Haufinyane, Gearhardt le basebetsi-mmoho ba phatlalalitse mofuta o ntlafalitsoeng oa YFAS. Ba qalile YFAS 2.0 (Gearhardt et al., 2016Karolo e 'ngoe e lumellane le litlhaloso tsa mathata a amanang le lithethefatsi le lithethefatsi ho DSM-5. Ho lemalla lijo ho khethoa ke boteng ba ho holofala ho hoholo ha lingaka hammoho le palo ea matšoao (maximum = 11) ea 2 kapa 3, 4 kapa 5, le ≥ 6 e emelang bokhoba ba lijo bo bobebe, bo itekanetseng le bo matla, ka ho latellana. Palo ea matšoao e fumanoe e hokahana hantle le boima ba 'mele' me, ka mohlala, le lintlha tse sekaleng tse lekanyang ho itlopa joala le ho ja lijo tse sa thibeloeng. Maemong a mangata YFAS le YFAS 2.0 li ts'oana haholo, leha bongata ba matšoao a mang bo le tlase ho YFAS 2.0 (mohlala, 'ho fokotsa' ts'ebeliso ea lijo tse itseng), ho bonahala eka ke ka lebaka la ho hlahisa lintho tse tlatsetsang.

Ho joalo, leha ho bile le likhanyetsano tse fapaneng tse boletsoeng kaholimo, ho ka pheha khang ea hore YFAS (le YFAS 2.0) ke tsela e amohelehang ea ts'ebetso ea ho lemalla lijo. Leha ho le joalo, bonyane karolo e kholo ea bohlokoa ba tšebeliso ea tlhekefetso joalo ka mohopolo o ka fihla moo e ka hlalosang boitšoaro bo fetisisang le tataiso ea ho kenella ho sebetsana ka katleho le ho qoba bothata (cf. Nako e telele le al., 2015). Seo se kanna, kapa ha se (Fairburn, 2013), tšoara 'nete bakeng sa ho nka BED e le bokhoba ba lijo, kapa mohlomong e le' tšenyo ea ho ja, 'kaha ha ho na lijo tse le' ngoe.Hebebrand et al., 2014). Ka lehlakoreng le leng, ho ka 'na ha se be molemo ho talima botenya, ntle le tlhahlobo ea BED, ka lebaka la bokhoba ba lijo. Mabaka a sena a tšohloa ka mor'a moo.

4.2. Na ho lemalla joala ka lijo ke mokhoa o thusang kapa o seng bohlale oa ho nona?

Joalokaha ho hlalositsoe pele (Karolo ea 3.7), ho ata ha botenya ho atile haholo ho feta ho ata ha ho itlopa lijo, ka hona kotsi e kholo e etsoang ke ho ja ka ho feteletseng ke litlamorao tsa botenya 'meleng le kelellong. Empa bokhoba ba lijo ha bo bonahale e le sesosa se ka sehloohong sa ho ja ka ho feteletseng se ikarabellang bakeng sa botenya. Mohlala, phuputso e 'ngoe e fumane hore ke 7.7% feela ea ba nkang karolo e fetang tekano kapa ba batenya haholo ba kopaneng le batho ba nang le takatso e matla ea litekanyetso tsa YFAS ha ba bapisoa le 1.6% ea ba nkang karolo e tlase le boima ba' mele. Mohlala ona oa batho ba 652 ba lulang Canada ts'oaetso ea ho nona haholo le botenya e ne e le 62% (Pedram et al., 2013). Ka ho hlakileng, tšebeliso ea matla a mangata ho feta litlhokahalo tsa matla e etsahala khafetsa khafetsa ho fapana le ho lemalla lijo.

Sena ha se bolele hore maseli a tsoang lipatlisisong tsa bokhoba ba tahi a ka 'na a se ke a fana ka litlatsetso bakeng sa botenya, empa ka tsela e tšoanang ho ka etsahala hore ho hlahisa bokhoba ba lithethefatsi tsa joala ho ka sitisa sepheo sa ho ja hanyane. Ho joalo, bukeng ea hae The Myth of Addiction, Davies (1992) e fana ka maikutlo a hore mohopolo oa bokhoba ba joala o ka se be kotsi leha o sebelisoa ts'ebelisong ea lithethefatsi tsa kelello. Mohlala o fana ka maikutlo a potoloho eo ho eona ho fetelletsa litlamorao tsa litlamorao tse tlisoang ke ho khaotsa lithethefatsi ho hlalosang (lebaka) la ts'ebeliso e mpe ea lithethefatsi. Ka lehlakoreng le leng, sena se phahamisa litebello mabapi le ho teba ha tefo, joalo joalo. Ka mokhoa o ts'oanang, bothata ba ho lumela hore thibelo ea lijo e tla etsa hore motho a ikutloe a lapile haholo, 'ho felloa ke matla,' kapa ho ikutloa o sa tenehe kapa o ferekane, ke hore sena se ka etsa hore ho ja ho theole boima ba 'mele ho boima ho feta kamoo ho ka bang ka teng. (Roger le Brunstrom, 2016). Ho lumela hore tšusumetso ea motho ea ho ja, ka mohlala, ice cream kapa kuku, e bakoa ke ho lemalla lijo, ho fana ka maikutlo a hore tšusumetso ha e laolehe, e leng se etsang hore ho be bonolo hore ice cream kapa kaka li hanoe (le cf. Karolo ea 3.3). Mohlala o mong ke hore tumelo e arolelanoeng ea takatso ea chokolete le hore sena ke 'chocoholism' se ka fokotsa tšusumetso ea motho le bokhoni ba ho ja chokolete e nyane (Rogers le Smit, 2000). Papiso ea tšusumetso e matla ea tumelo ho boiphihlelo ba takatso ea lijo ke thuto eo ho eona barupeluoa ba ileng ba tataisoa hore ba utloisise hore lijo tse nang le metsi li tla bola ka mpeng. Tumelo ena e le 'ngoe (ntle le phello ea li-gelling) e ile ea eketseha ho utloisisa botlalo, ea fokotsa ho ja ka morao, mme e boetse e ama ho lokolloa ha li-hormone tsa gastro-intestinal le phokotso ea ho theoha hoa mali ka mpeng (Cassady et al., 2012).

Sena se hlahisa potso mabapi le phello ea ho ngola lijo tse itseng e le ho lemalla. Phuputsong e sa tsoa etsoa (Hardman et al., 2015) bankakarolo ba ithutile litemana tse tharo ho itukisetsa teko ea morao-rao ea mohopolo oa litaba tsa bona. Temana ea boraro e ne e bua ka ho lemalla lijo, 'me halofo ea bankakarolo ba amohela mofuta o reng ho lemalla lijo ke ntho ea' nete 'me halofo e amohela mofuta o reng ke tšōmo. Ho seo barupeluoa ba ileng ba tataisoa hore ba lumele hore ke thuto e arohaneng, ba ile ba nka karolo ho 'teko ea tatso' moo ba ileng ba lekola lijo tse 'ne, mme ba tloheloa ba le bang bakeng sa 10 min ho ja lijo tse ngata kamoo ba neng ba lakatsa. Ho jeoa ha li-crisps le li-cookie (lijo tsa mofuta oo ho neng ho thoe li lemalla) e ne e le 31% e phahameng (e seng ea bohlokoa) mme e fapane hofeta le sehlopheng sa bokhoba ba tahi ho feta sehlopheng sa litšōmo. Ho ne ho se na phapang lipakeng tsa lijo tse ling tse peli (morara le lithupa tsa bohobe). Sephetho se seng e bile hore ho qhekella ho amme ho itlhahloba ha bokhoba ba lijo - barupeluoa ba bangata sehlopheng seo ke makhoba a tahi ba arabile ka potso ea 'Na u ipona u le lekhoba la lijo?' ho feta ba nkang karolo sehlopheng sa litšōmo. Sephetho se seng sa phuputso ena ke hore khothaletso e kantle ea mohopolo oa bokhoba ba lijo e khothaletsa batho ho inka e le makhoba a lijo, ka lebaka leo ho ka etsahalang hore ba ka ja lijo tsa bona. Phapang e kholo ea ho ja lijo tse ka 'nang tsa fetoha lithethefatsi' e supa litlamorao tse peli tse fapaneng tsa tumelo ea ho lemalla lijo, e leng ho qoba lijo ka lebaka la ho tšaba ho lahleheloa ke taolo khahlanong le ho inehela ho hloleha hoa taolo. Kahoo ho lemoha boits'oaro bo tlatselletsang mabapi le bokhoba ho ka ba molemo kapa ha thusa ho qoba kotsi. Ka ho hlakileng, ho ka lebelloa hore phello e tla itšetleha ka sethaleng sa ts'ebeliso ea lithethefatsi. Mohlala, ho mocha ea nahanang ho tsuba koae, mohopolo oa hore koae e lemalla haholo o ka ba sitisa ho tsuba. Leha ho le joalo, bakeng sa batho ba tsubang ba 20 ka letsatsi tsebo ena e kanna ea thibela boiteko ba ho tsuba.

4.3. Kotsi ea ho lemalla

Joalokaha ho hlalositsoe pejana (Karolo ea 2), monyetla oa ho lemalla o fapana haholo ho tsoa linthong tse fapaneng. Heroin e ka lemalla haholo, ea chokolete haholo. Haholo, ho bapisoa lipakeng tsa litlamorao tsa cocaine le meputso ea lijo li fumane hore lijo tse thibelang likhoto li ile tsa khetha lijo ka lebaka la ho kenella ka har'a koae ho 70-80% ea liteko (Tunstall le Kearns, 2014). K'hok'heine le thomello ea lijo li entsoe ka pente e fapaneng. Lesela le koahetsoeng ka koae le fumanoe le thusa ho arabela hape ka mor'a ho timela ka matla ho feta ho etsa ka leseli le entsoe ka lijo. Sephetho sena se ka hlalosoa e le se bonts'ang takatso e kholo ea lijo empa takatso e kholo ea cocaine (Tunstall le Kearns, 2014), e tsamaellanang le cocaine e hlahisang kotsi e kholo ea ho lemalla ho fapana le lijo. Mabapi le phapang lipakeng tsa lijo ho khothalelitsoe hore bokhoba bo amanang haholo le lijo tse ntlafalitsoeng haholo (Schulte et al., 2015). Tsena ke lijo tse nang le bongata bo bongata ba glycemic (ke hore, li na le tsoekere e ngata le / kapa lik'habohaedreite tse ling tse hloekisitsoeng), kapa li na le mafura a mangata kapa tse peli. Ka mokhoa o makatsang, ho hohela holimo, kapa 'hyper-palatability' ea lijo tse joalo ka tekanyo e kholo ho litsobotsi tsa tsona tsa tatso, haholo monate oa tsona, letsoai le / kapa ho bolokoa (tatso ea Umami), tseo kaofela li ratoa haholo ke batho, hammoho le matla a bona a phahameng. Ho reriloe hore lijo tse nang le mafura a mangata li fumane boleng bo phahameng ba moputso ka lebaka la maro a tsona a mangata (haholo-holo lik'habohaedreite le mafura) ho karolelano ea satiety (Roger le Brunstrom, 2016). Lebaka ke hobane ho ja lijo tse nang le phepo e ntle ke sepheo sa ho qetela sa ho ja, empa ho khotsofatsa ho ja ho feta tekano. Kahoo ho fumaneha haholo ha lijo tse matla tse nang le mafura ho loketse ho khothaletsa tšebeliso ea matla a mangata ka mabaka a mabeli a amanang: lia khahleha ebile li fokolisa matla a khoheli ka khalori. Leha ho le joalo, tšebeliso ena e feteletseng ea matla le ho nona ho feta boima ba 'mele le botenya haholo li etsahala ha ho se na lithethefatsi tsa lijo tsena ntle le hore, ke ho re, tšenyo ea lijo e hlalositsoe ka mokhoa o hlakileng (Karolo ea 4.2).

Kotsi ea ho lemalla e boetse e fapana ho batho ka bomong (joalo ka ha ho le kotsing ea ho ba le botenya), mme phapang ea karabelo ea moputso e ile ea tšohloa ho Karolo ea 3.9. Tlhatlhobo e tsoelang pele ea liphapang tsa motho ka mong ts'ebetsong ea ho lemalla lithethefatsi e kantle ho tekolo ena, ntle le ho hlokomela hore lintlha tse ngata tse sebelisanang li kentse letsoho ho lekanyetsa kotsi ea motho ea ho lemalla (Altman et al., 1996 'me West le brown, 2013). Tsena li kenyeletsa, ka mohlala, liphatsa tsa lefutso, tsoelo-pele, boits'oaro, tikoloho, moruo le bochaba le maemo a molao. Ho kenyelletsoa mona ho lekana le phihlello ea moputso oo e seng lithethefatsi (le tseo e seng lijo). Tse ling tsa lintlha tsena tse behang bophelo kotsing li ka fetoha habonolo ho feta tse ling.

Mabapi le ho ja haholo, tikoloho lichabeng tse tsoetseng pele e tletse ka lijo. Botebo ba litaele tsa lijo le phihlello ea lijo tse sa sebetseng, haholo-holo lijong tse matla haholo, li khothaletsa tšebeliso ho feta litlhoko tsa hanghang (Roger le Brunstrom, 2016). Phapang e le 'ngoe ea tšusumetso le bokhoni ba ho hanela moputso oa lijo li tla lekana hore na ke mang ea mafura, empa phetoho maemong a lijo a ka thusa haholo ba tlokotsing ea ho ja haholo. Ho etsa mohlala, UK, mohlala, lijo tse letsoang tse theotsoeng li rekisoa ka mafolofolo ('li sutumetsoa') libakeng tsa Checkout, ho kenyelletsoa le mabenkeleng a sa rekiseng lijo. Mohlomong qetellong tloaelo ena e tla khaotsa hobane, joalo ka lino tse tahang kapa lihlahisoa tsa koae, ho etsa sena ho tla nkuoa ho le kotsi ho bophelo ba sechaba.

5. Maikutlo le sephetho sa ho qetela

Tlhahlobo ea hona joale e bonts'a ho ts'oana, empa le liphapang tse ling, litlamong tse susumetsang tsa lijo le lithethefatsi tsa tlhekefetso. Ka kakaretso, lithethefatsi tse lemalloang li na le litlamorao tse ngata ho feta lijo, haholo-holo mabapi le litlamorao tsa tsona bokong tse etsang hore ba 'batloe.' Le ha ho ja ka mokhoa o phehellang ho ka hlalosoa e le mokhoa oa ho lemalla, ho ja ka kotloloho hase sesosa sa ho ja haholo, hobane ho na le tšoaetso e tlase haholo ho feta ho nona ho feta tekano kapa botenya. Sebakeng sa ho bonoa mabapi le bokhoba ba lijo, ho ja ka mokhoa o fetelletseng ho hlalosoa hamolemo ke ho fumaneha ka bongata, ho hohela le bokhabane bo tlase ba satiating (khalori ea khalori) ea lijo tse letsoalo tse matla. Ho phehisanoe hore ho theha bokhoba ba lijo tse joalo ho tla thusa ho susumetsa baetsi ba melaoana le ba bang ho thibela thekiso le ho fumaneha ha lijo tse joalo, joalo ka ha ho entsoe ka katleho, mohlala, bakeng sa ho tsuba ka phokotso ea ho ata ha ho tsuba le ho tsuba. -related bophelo bo botle (Gearhardt et al., 2011a). Leha ho le joalo, ho pharalla ha litlhaloso tsa bokhoba hore sena se ka hloka ho ka fokolisa phello ea sona haholo. Ho eketsa bokhoba ba lijo ka tsela ena ho boetse ho beha likotsi tse tebileng, kapa ho ka etsa hore lijo tse itseng (ke hore, 'lijo tse tlatsetsang') li utloisisehe le ho feta. E kanna ea ba le litlamorao tsena tsohle tse sa lebelloang.

Papiso e 'ngoe ea kamoo mantsoe a fanang ka taba e fanoa ke pontšo ea hore ntho e tsosang takatso e tšoanang (1: motsoako oa 1 oa isovaleric le asyric acid) e nkoa e le monate haholo haeba e ngotsoe joalo ka chisi ea Parmesan ho feta haeba e ngotsoe joalo ka ho hlatsa.Herz le von Clef, 2001). Ka mokhoa o ts'oanang, ho sebelisa 'ho lakatsa,' ho hlalosa ho ba le takatso e matla ea ho ja chokolete, ho "loma" ho hlalosa ho ja lijo tse ngata (kapa ho se kholo haholo), hape ho ba 'setlokotsebe sa lijo' ho hlalosa ho tloaela ho ja ka bongata, ho susumetsa ho fapaneng. maikutlo a liphihlelo tsena tse tloaelehileng. Taba ke hore ho nahana ka lijo tse matlafatsang ka ho fetelletseng joalo ka bokhoba ba lijo ebile ha ho hlalose ho ja ho tlōla kapa hona ho fana ka maano a ho fokotsa ho ja haholo.

'Re tlameha ho ithuta ho tšoara mantsoe hantle; empa ka nako e ts'oanang re tlameha ho boloka 'me, ha ho hlokahala, ho matlafatsa bokhoni ba rona ba ho sheba lefatše ka kotloloho eseng ka kotloloho ea mehopolo e mahareng, e nyenyefatsang ntlha e ngoe le e' ngoe e fuoeng ka mokhoa o tloaelehileng haholo oa mofuta o itseng oa mangolo kapa litlhaloso tšitiso. '

Ho tsoa ho The Doors of Perception, ka Aldous Huxley.

Likhohlano tse ka bang teng tsa thahasello le boipolelo

Sengoli se fumane chelete ea ho etsa lipatlisiso mabapi le litlamorao tsa tsoekere ho takatso ea lijo le ho ikhotsofatsa ho tsoa ho Nutrition UK. 47190). O fane ka lits'ebeletso tsa boeletsi ho Coca-Cola Great Britain mme o fumane litefiso tsa sebui ho tsoa ho Mokhatlo oa Machaba oa Li-Sweeteners. Mehopolo e amanang le moputso oa lijo, satiety ea kamora 'prandial le matla a matla e ntlafalitsoe ka karolo e' ngoe nakong ea tokiso ea thuso e tšehelitsoeng ke BBSRC DRINC (BB / L02554X / 1). Karolo ea lipatlisiso tse lebisang tlhahlobisong ena e amohetse chelete ho tsoa Lenaneong la Boraro la European Union bakeng sa lipatlisiso, nts'etsopele ea mahlale le pontsho tlasa tumellano ea tumello ea. 607310.

References

1.      

  • Altman et al., 1996
  • J. Altman, BJ Everitt, S. Glautier, A. Markou, D. Nutt, R. Oretti, GD Phillips, TW Robbins
  • Metheo ea tlhaho, ea kahisano le ea bongaka ea ho lemalla lithethefatsi: litlhaloso le ngangisano
  • Psychopharmacology, 125 (1996), maq. 285-345
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (213)

2.      

3.      

  • Avena et al., 2008
  • NM Avena, P. Rada, BG Hoebel
  • Bopaki ba ho lemalla tsoekere: lits'ebeletso tsa boitšoaro le tsa methapo ea metsoako ea methapo ea tsoekere e feteletseng
  • Neurosci. Biobehav. Tshenolo, 32 (2008), maq. 20-39
  • Sehlooho se

|

 PDF (635 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (513)

4.      

  • Baumeister et al., 1994
  • RF Baumeister, TF Hetherington, DM Tice
  • Taolo ea tahlehelo. Batho ba Bang, Le Hobaneng Batho ba Hlleha ho itaola?
  • Press Press, San Diego (1994)
  •  

5.      

  • Berridge, 1996
  • KC Berridge
  • Moputso oa lijo: likarolo tse ling tsa boko tse ratoang le tse batloang
  • Neurosci. Biobehav. Tshenolo, 20 (1996), maq. 1-25
  • Sehlooho se

|

 PDF (3141 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (952)

6.      

 | 

Ho qotsa lihlooho (258)

7.      

  • Blum et al., 1990
  • K. Blum, EP Nobel, PJ Sheridan, A. Montgomery, T. Ritchie, P. Jagadeeswaran, H. Nogami, AH Briggs, JB Cohn
  • Mokhatlo o kopaneng oa "dopamine" oa motho2 gene ea receptor bokhobeng ba joala
  • J. Am. Moedi Assoc., 263 (1990), maq. 2005-2060
  • Sheba tlaleho ka Scopus

8.      

 | 

Ho qotsa lihlooho (151)

9.      

  • Carelli, 2002
  • RM Carelli
  • Liteishene tsa nyutlelie li bokella ho thunya ha sele nakong ea boits'oaro bo tataisitsoeng bakeng sa ts'ebeliso ea koae vs. 'tlholeho'
  • Physiol. Behav., 76 (2002), maq. 379-387
  • Sehlooho se

|

 PDF (199 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (112)

10.   

  • Cassady et al., 2012
  • BA Cassady, RV Considine, RD Mattes
  • Tšebeliso ea lino tse tahang, takatso ea lijo le takatso ea matla: o ne o lebelletse eng?
  • Na. J. Clin. Nete., 95 (2012), maq. 587-593
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (75)

11.   

|

 PDF (128 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (80)

12.   

  • Colantuoni et al., 2002
  • C. Colantuoni, P. Rada, J. McCarthy, C. Patten, NM Avena, A. Chadeayne, BG Hoebel
  • Bopaki ba hore tsoekere e feteletseng, e feteletseng ea tsoekere e etsa hore motho a itšetlehe haholo ka ho itšetleha ka opioid
  • Lintho. Res., 10 (2002), maq. 478-488
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (299)

13.   

  • Cornell et al., 1989
  • CE Cornell, J. Rodin, H. Weingarten
  • Lijo tse susumetsoang ke khothaletso ha li khothatsoa
  • Physiol. Behav., 45 (1989), maq. 695-704
  • Sehlooho se

|

 PDF (831 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (157)

14.   

  • Corr, 2008
  • PJ Corr
  • Khopolo ea Reinforcing Sensitivity ea Botho
  • Khamphani ea Khatiso ea Cambridge, Cambridge (2008)
  •  

15.   

  • Davies, 1992
  • JB Davies
  • Khopolo-taba ea Ho Lemalla
  • Bahatisi ba Harwood Academic, ho bala UK (1992)
  •  

16.   

  • de Araujo et al., 2008
  • IE de Araujo, AJ Oliveira-Maia, TD Sotnikova, RR Gainetdinov, MG Caron, MA Nicolelis, SA Simon
  • Moputso oa lijo ha o sa latsoe tatso ea li-receptor
  • Neuron, 57 (2008), maq. 930-941
  • Sehlooho se

|

 PDF (1094 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (202)

17.   

  • de Wit, 1996
  • H. de Wit
  • Litlamorao tsa litla-morao tsa lithethefatsi le tse ling tse matlafatsang
  • Hlakola Clin. Psychopharmacol, 4 (1996), maq. 5-10
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (179)

18.   

  • Di Chiara, 2005
  • G. Di Chiara
  • Dopamine likhatellong tsa lijo le boitšoaro bo khothalletsoang ke lithethefatsi: nyeoe ea thuto ea lapeng?
  • Physiol. Behav., 86 (2005), maq. 9-10
  • Sehlooho se

|

 PDF (62 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (39)

19.   

  • Epstein le Shaham, 2010
  • DH Epstein, Y. Shaham
  • Likhoto tse jang cheesecake le potso ea ho lemalla joala
  • Nat. Neurosci., 13 (2010), maq. 59-531
  •  

20.   

  • Everitt le Robbins, 2005
  • BJ Everitt, TW Robbins
  • Mekhoa ea mekhoa e metle ea ts'ebeliso ea ho lemalla lithethefatsi: ho tloha liketsong ho tloaelehileng
  • Nat. Neurosci., 8 (2005), maq. 1481-1489
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (1687)

1.      

  • Fairburn, 2013
  • CG Fairburn
  • Ho hlola ho ja ho ja
  • (Ed ed Second.) Guilford Press, New York (2013)
  •  

2.      

  • Ferriday le Brunstrom, 2011
  • D. Ferriday, JM Brunstrom
  • 'Ha ke khone ho ithusa': litlamorao tsa ho pepeseha ha lijo ho batho ba nonneng haholo le ba its'epileng
  • Int. J. Obes., 35 (2011), maq. 142-149
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (54)

3.      

  • Gable et al., 2016
  • PA Gable, NC Mechin, LB Neal
  • Litloaelo tsa Booze le tsepameng tse lebisang tlhokomelo: litloaellano tsa methapo ea kutlo ea noople e nooang
  • Psychol. Motlatsi. Behav., 30 (2016), maq. 377-382
  • CrossRef

|

Sheba tlaleho ka Scopus

4.      

|

 PDF (193 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (260)

5.      

  • Gearhardt et al., 2016
  • AN Gearhardt, WR Corbin, KD Brownell
  • Nts'etsopele ea mofuta oa Yale Food Addiction Scale 2.0
  • Psychol. Motlatsi. Behav., 30 (2016), maq. 113-121
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (7)

6.      

  • Gearhardt et al., 2011a
  • AN Gearhardt, CM Grilo, RJ DiLeone, KD Brownwell, MN Potenza
  • Na lijo li ka lemalla? Bophelo bo botle sechabeng le litlamorao tsa melaoana
  • Tlatsetso, 106 (2011), maq. 1208-1212
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (117)

7.      

  • Gearhardt et al., 2011b
  • AN Gearhardt, S. Yokum, PT Orr, E. Stice, WR Corbin, KD Brownwell
  • Litekanyetso tsa Neural tsa ts'ebeliso ea lithethefatsi
  • Sethapo. Gen. Psychiatry, 68 (2011), maq. 808-816
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (212)

8.      

|

 PDF (180 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (80)

9.      

  • Hardman et al., 2012
  • CA Hardman, VMB Herbert, JM Brunstrom, MR Munafò, PJ Rogers
  • Moputso oa lijo le litheko tsa lijo: litlamorao tsa ho hlobaela ho hlobaetsang ha tyrosine / phenylalanine ka takatso ea lijo
  • Physiol. Behav., 105 (2012), maq. 1202-1207
  • Sehlooho se

|

 PDF (191 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (10)

10.   

  • Hardman et al., 2015
  • CA Hardman, PJ Rogers, R. Dallas, J. Scott, HK Ruddock, E. Robinson
  • “Tebello ea lijo ke 'nete”. Litlamorao tsa ho pepesetsoa molaetsa ona mabapi le bokhoba ba lijo le litloaelo tsa ho ja
  • Takatso ea lijo, 91 (2015), maq. 179-184
  • Sehlooho se

|

 PDF (282 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (4)

11.   

  • Hardman et al., 2014
  • CA Hardman, PJ Rogers, NJ Timpson, MR Manufò
  • Ho hloka setsoalle lipakeng tsa DRD2 le OPRM1 genotypes le adiposity
  • Int. J. Obes., 38 (2014), maq. 730-736
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (10)

12.   

  • Hebebrand et al., 2014
  • J. Hebebrand, Ö. Albayrak, R. Adan, J. Antel, C. Dieguez, J. de Jong, G. Leng, J. Menzies, JG Mercer, M. Murphy, G. van der Plasse, S. Dickson
  • “Ho lemalla joala”, ho e-na le “bokhoba ba lijo”, bo hlahisa mekhoa e metle e kang ea ho ja
  • Neurosci. Biobehav. Tshenolo, 47 (2014), maq. 295-306
  • Sehlooho se

|

 PDF (1098 K)

13.   

  • Herz le von Clef, 2001
  • RS Herz, J. von Clef
  • Tšusumetso ea ho ngola mantsoe ka mantsoe mabapi le monko: bopaki ba litlolo tse fosahetseng?
  • Perception, 30 (2001), maq. 381-391
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (108)

14.   

  • Johnson le Kenny, 2010
  • PM Johnson, PJ Kenny
  • Li-receptor tsa Dopamine D2 ka mokhoa o joalo oa ho se sebetse hantle joalo ka moputso
  • Nat. Neurosci., 13 (2010), maq. 635-641
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (556)

15.   

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (10)

16.   

  • Koob et al., 2014
  • GF Koob, MA Arens, M. Le Moal
  • Lithethefatsi, Bokhoba ba Bohloko le Boko
  • Litaba tsa thuto, Oxford (2014)
  •  

17.   

  • Koob le Volkow, 2016
  • GF Koob, ND Volkow
  • Ntho ea phekolo ea methapo ea bothata: ho hlahlojoa ha methapo ea pelo
  • Lancet Psych., 3 (2016), maq. 760-773
  • Sehlooho se

|

 PDF (821 K)

|

Sheba tlaleho ka Scopus

18.   

  • LeGoff et al., 1988
  • DB LeGoff, P. Leichner, MN Spigelman
  • Karabelo e matla ea ho susumetsoa ke lijo tse hlasimolohileng ho anorexics le bulimics
  • Takatso ea lijo, 11 (1988), maq. 15-25
  • Sehlooho se

|

 PDF (716 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (38)

19.   

  • Nako e telele le al., 2015
  • CG Long, JE Blundell, G. Finlayson
  • Tlhahlobo e hlophisehileng ea ts'ebeliso le li-correlates tsa "ts'oaetso ea lijo" tse fumanoeng ke YFAS ho batho: na 'litumelo tse amanang le ho ja' ke lebaka la ho tšoenyeha kapa mehopolo e se nang thuso?
  • Lintho. Lintlha, 8 (2015), maq. 386-401
  • CrossRef

|

Sheba tlaleho ka Scopus

20.   

  • Meule, 2015
  • A. Meule
  • E khutlisoa ke tlhoko e tsebahalang: tlhahlobo e phetang ka nalane ea lipatlisiso tsa ho lemalla lijo
  • Yale J. Biol. Med., 88 (2015), maq. 295-302
  • Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (9)

1.      

  • Munafò et al., 2007
  • MR Munafò, IJ Matheson, J. Flint
  • Mokhatlo oa DRD2 gene Taq1A polymorphism le joala: tlhahlobo ea meta-lithuto tsa taolo ea linyeoe le bopaki ba khethollo ea phatlalatso
  • Mol. Psychiatry, 12 (2007), maq. 454-461
  • Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (137)

2.      

  • Nader le Czoty, 2005
  • MA Nader, PW Czoty
  • Ho nahanisisa ka PET ea li-receptor tsa dopamine D2 mefuteng ea litšoene tsa tlhekefetso ea cocaine: tsoelopele ea liphatsa tsa lefutso le phallo ea tikoloho
  • Am. J. Psychiatr., 162 (2005), maq. 1473-1482
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (88)

3.      

  • Ng et al., 2014
  • M. Ng, T. Fleming, M. Robinson, B. Thomson, N. Graetz, et al a.
  • Ho ata ha lefats'e, tikoloho, le naha ho ata ha botona le botšehali ho bana le batho ba baholo ka nako ea 1980-2013: tlhahlobo e hlophisitsoeng ea Global Burden of Disease Study 2013
  • Lancet, 384 (2014), maq. 766-781
  • Sehlooho se

|

 PDF (17949 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (1425)

4.      

  • Peciña le Berridge, 2005
  • S. Peciña, KC Berridge
  • Sebaka se chesang sa Hedonic ho li-nucleus li bokella: u li etsa joang μ-opioids e baka tšusumetso e matla ea hedonic ea monate?
  • J. Neurosci., 14 (2005), maq. 11777-11786
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (284)

5.      

6.      

  • Petrovich et al., 2002
  • GD Petrovich, B. Setlow, PC Holland, M. Gallagher
  • Potoloho ea Amygdalo-hypothalamic e lumella lintlha tse ithutoang ho feta ho satiety le ho khothaletsa ho ja
  • J. Neurosci., 22 (2002), maq. 8748-8753
  • Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (133)

7.      

  • Robinson le Berridge, 1993
  • TE Robinson, KC Berridge
  • Motheo oa neural oa takatso ea lithethefatsi: khopolo ea ho khothalletsa batho ho tsuba
  • Brain Res. Tshenolo, 18 (1993), maq. 247-291
  • Sehlooho se

|

 PDF (7973 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (4235)

8.      

  • Rogers, 1985
  • PJ Rogers
  • Ho khutlisetsa likhoto tsa 'phepelo ea lijo tsa khathollo ea lijo' ho ja lijo tse fapaneng: phapang e mpe le litlamorao tsa botena ho boitšoaro ba ho ja
  • Physiol. Behav., 35 (1985), maq. 493-499
  • Sehlooho se

|

 PDF (678 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (36)

9.      

  • Rogers, 1999
  • PJ Rogers
  • Mekhoa ea ho ja le taolo ea takatso ea lijo: pono ea psychobiological
  • Proc. Nutr. Soc., 58 (1999), maq. 59-67
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (36)

10.   

|

 PDF (343 K)

|

Sheba tlaleho ka Scopus

11.   

|

 PDF (1099 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (7)

12.   

  • Roger et al., 2013
  • PJ Rogers, SV Heatherley, EL Mullings, JE Smith
  • E potlakileng empa eseng e bohlale: litlamorao tsa ho tlohela kofi le koae ka ho ba hlokolosi le ts'ebetso
  • Psychopharmacology, 226 (2013), maq. 229-240
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (24)

13.   

  • Rogers le Smit, 2000
  • PJ Rogers, HJ Smit
  • Takatso ea lijo le "tšebeliso ea lijo": tlhahlobo e thata ea bopaki bo tsoang ponong ea biopsychosocial
  • Pharmacol. Biochem. Behav., 66 (2000), maq. 3-14
  • Sehlooho se

|

 PDF (159 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (177)

14.   

|

 PDF (241 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (28)

15.   

  • Schulte et al., 2015
  • EM Schulte, NM Avena, AN Gearhardt
  • Ke lijo life tse ka u lematsang? Karolo ea ho sebetsa, likarolo tsa mafura le mojaro oa glycemic
  • PloS One, 10 (2015) e0117959
  •  

16.   

17.   

  • Stice le Yokum, 2016
  • E. Stice, S. Yokum
  • Lintho tse ka fokolisang tšoaetso ea Neural tse eketsang kotsi ea ho eketsa boima ba nako e tlang
  • Psychol. Bull., 142 (2016), maq. 447-471
  • CrossRef

|

Sheba tlaleho ka Scopus

18.   

  • Mathata le al., 1994
  • EC Strain, GK Mumford, K. Sliverman, RR Griffiths
  • Sesepa sa ho its'etleha ka k'hafeine: bopaki bo tsoang nalaneng ea linyeoe le tlhahlobo ea liteko
  • J. Am. Moedi Assoc., 272 (1994), maq. 1043-1048
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (135)

19.   

  • Stunkard le Messick, 1985
  • AJ Stunkard, S. Messick
  • Potso ea lintlha tse tharo tsa ho ja ho lekanya mokhoa oa ho itšireletsa mafung, disinhibition le tlala
  • J. Psychosom. Res., 29 (1985), maq. 71-83
  • Sehlooho se

|

 PDF (1021 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (2504)

20.   

  • Teff, 2011
  • KL Teff
  • Tsela eo neural mediation ea linyatso tsa insulin e lebelletsoeng le e khothalletsang ka eona e re thusang ho mamella lijo
  • Physiol. Behav., 103 (2011), maq. 44-50
  • Sehlooho se

|

 PDF (378 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (39)

1.      

  • Tellez et al., 2016
  • LA Tellez, W. Han, X. Zhang, TL Ferreira, IO Perez, SJ Shammah-Lagnado, AN van den Pol, IE de Araujo
  • Likarolo tse arohaneng li kenyelletsa boleng ba hedonic le phepo e nepahetseng
  • Nat. Neurosci., 19 (2016), maq. 465-470
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (16)

2.      

  • Tiffany, 1995
  • ST Tiffany
  • Karolo ea lintlha tse hlakileng mabapi le ho kopana hape le litsi tsa lithethefatsi
  • DC Drummond, ST Tiffany, S. Glautier, B. Remmington (Eds.), Boitšoaro ba Boitšoaro: Khopolo ea ho itlhahisa le Cue, Wiley, Chichester, UK (1995), maq. 137-165
  •  

3.      

  • Tunstall le Kearns, 2014
  • BJ Tunstall, DN Kearns
  • Cocaine e ka hlahisa moriana o matlafatsang ho feta lijo le ha e le matlafatso ea mantlha e fokolang
  • Motlatsi. Biol., 21 (2014), maq. 282-293
  •  

4.      

  • Wang et al., 2001
  • G.-J. Wang, ND Volkow, J. Logan, NR Pappas, CT Wong, W. Zhu, N. Netusil, JS Fowler
  • Dopamine ea boko le botenya
  • Lancet, 357 (2001), maq. 354-357
  • Sehlooho se

|

 PDF (274 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (962)

5.      

 | 

Ho qotsa lihlooho (216)

6.      

7.      

  • Wiepkema, 1971
  • PR Wiepkema
  • Liphephetso tse nepahetseng mosebetsing nakong ea ho fepa
  • Boitšoaro, 39 (1971), maq. 266-273
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (85)

8.      

  • Woods, 1991
  • SC Woods
  • Papatso ea ho ja: kamoo re mamellang lijo
  • Psychol. Tshenolo, 98 (1991), maq. 488-505
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (211)

9.      

  • Mokhatlo oa Lefatše oa Bophelo, 1992
  • Mokhatlo oa Lefatše oa Bophelo
  • Classified ea ICD-10 ea Mathata a Kelello le Boitšoaro: Litlhaloso tsa Kliniki le Tataiso ea Tlhahlobo
  • Mokhatlo oa Lefatše oa Bophelo, Geneva (1992)
  •  

10.   

  • Yeomans, 1996
  • MR Yeomans
  • Ho tsebahala ka botlalo le mokhoa o fokolang oa ho fepa ho batho: phello ea takatso ea lijo
  • Takatso ea lijo, 27 (1996), maq. 119-133
  • Sehlooho se

|

 PDF (189 K)

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (148)

11.   

  • Yeomans et al., 1998
  • MR Yeomans, H. Spetch, PJ Rogers
  • Litefiso tse nang le tatso e nang le boemo bo matlafatsoang li matlafatsoa ke caffeine ho baithaopi ba batho
  • Psychopharmacology, 137 (1998), maq. 401-409
  • CrossRef

|

Sheba tlaleho ka Scopus

 | 

Ho qotsa lihlooho (68)

12.   

 | 

Ho qotsa lihlooho (166)

Setsi sa Phepo e Nepahetseng le Boitšoaro, Sekolo sa Tlhahlobo ea Mahlale, Univesithi ea Bristol, 12a Tsela ea Motlakase, Bristol BS8 1TU, UK.

© 2017 Sengoli. E phatlalalitsoe ke Elsevier Inc.