Genese Brain Behav. 2013 Apr;12(3):311-22. doi: 10.1111/gbb.12020.
Akubuiro A1, Bridget Zimmerman M, Boles Ponto LL, Walsh SA, Sunderland J, McCormick L, Singh M.
inahaneloang
AdAR2 transgenic mice misexpressing RNA editing enzyme ADAR2 (Adenosine Deaminase e sebetsang ho RNA) e bonts'a litšobotsi tsa ho nona le ho ba le botenya ba ho qala ho ba motenya. Mekhoa ea boitšoaro le liphetoho tsa boko tse amanang le tšebeliso e mpe ea lithethefatsi ho litoeba tsena tsa transgenic li ile tsa hlahlojoa ha litšoene tsa transgenic li bontša hyperphagia e sa foleng. Litoeba tsa transgenic tsa ADAR2 li ile tsa hlahlojoa ho khetho ea tsona ea lijo le tšusumetso ea ho ja ho feta tikolohong ea tlholisano ea moputso ka phihlello ea lipapatso ka lebelo la lipapatso le lijo. Ts'ebetso ea metabolism ea boko le lithane tsa peripheral li ile tsa hlahlojoa ka [(18) F] fluorodeoxyglucose positron emission tomography (FDG-PET) le polelo ea RNA ea liphatsa tsa lefutso tse amanang, ADAR2, dopamine le li-opiate receptors tse tsoang hypothalamus le striatum li ile tsa hlahlojoa. Liphetho li bonts'a hore ADAR2 transgenic mice pontshi, (1) khetho ea lijo bakeng sa lijo tse nang le mafura a mangata, (2) haholo keketseho ea lijo tse sa sebetseng tikolohong ea moputso ea tlholisano, (3) e eketsehileng haholo len messengerosa RNA (mRNA) Polelo ea ADAR2, serotonin 2C receptor (5HT2C R), D1, D2 le li-op opioid receptors mme ha ho na phetoho ea li-mRNA tsa corticotropin tse lokollang le ho fokotsa haholo tlhahiso ea protheine ea "corticotropin" le ho theola haholo protheine ea proteni ea ADAR2 ho hypothalamus, (4) le 1. phetoho ho ADAR2, mu opioid le polelo ea D2 receptor mRNA ka har'a striatum le (5) metabolism e kholo ea tsoekere ho hypothalamus, stem ea boko, hippocampus e ka letsohong le letšehali, le ka letsohong le letona le bohareng la methapo ho feta taolo. TLiphetho tsa hese li fana ka maikutlo a hore boits'oaro bo feteletseng bo nang le sepheo sa bo-maiketsetso ba ADAR2 ba amanang le phepelo e fetotsoeng, li-mRNA tse amanang le moputso le sebaka se matla sa kelello sa mesolimbic.
PMID: 23323881
PMCID: PMC4589229
DOI: 10.1111 / gbb.12020
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