Na botenya bo hokahantsoe le ADHD?
Ha bana ba ntseng ba eketseha ba ja lijo tse nang le mafura a mangata mme ba ntse ba eketseha ka bongata, maemo a mafu a kang lefu la tsoekere la 2 le khatello e phahameng ea mali a eketsehile ka sekhahla har'a baahi. Leha ho le joalo, tsena ha se tsona feela mathata a bophelo bo botle a amanang le ts'ebetso ena ea ho ja ho feta tekano bathong. Phuputsong ea morao-rao ho tsoa Univesithing ea Illinois, bafuputsi ba fumane hore lijo tse nang le mafura a mangata li kanna tsa amahanngoa le khatello ea maikutlo, khatello ea maikutlo, ho tšoenyeha le ADHD.
Ba sebelisitse litoeba tsa libeke tse 'ne ho bona hore na boits'oaro ba liphoofolo bo ka ameha ka ho beha liphoofolo lijong tse nang le mafura a mangata ho isa ho a mararo. Litoeba li ne li arotsoe ka boomo ka lihlopha tse peli; sehlopha sa pele se jele lijo moo 60% ea likhalori li tsoang mafura, mme sehlopha sa bobeli se jele sejo seo ho sona ho nang le liperesente tse 10 feela tsa likhalori tse tsoang mafura. Kamora beke e le 'ngoe ba jele lijo tse nang le mafura a mangata, litoeba tse qalang ka sehlopha li ile tsa bontša keketseho maemo a ho tšoenyeha joalo ka ha ho pakoa ke ho qeta nako e ngata ho phunya le ho matha ka mabili. Ntle le moo, litoeba tsa sehlopha sa pele li ne li le leqe ho hlahloba li-quadrants tse bulehileng tsa maze ea zero. Ba ne ba boetse ba sitoa ho tsamaea Y-maze le ho amohela ntho e ncha.
Ha bafuputsi ba sekaseka cortex, hippocampus le hypothalamus bakeng sa dopamine sehlopheng sa litoeba, ba ile ba fumana litekanyetso tse eketsehileng tsa homovanillic acid (HVA) hippocampus le cortex. HVA ke tšebeliso ea litholoana tse hlahisoang ha dopamine e sebelisoa. Seo se bolela hore maemo a dopamine sehlopheng sa litoeba tse le ngoe a ne a le tlase. Dopamine e bohlokoa hobane ke neurotransmitter e romellang litšusumetso tse tsoang seleng ea methapo ea kutlo ho leqhubu le leng, setho kapa thipa. Maemo a tlase a dopamine a ama hampe matla a ho nahana, ho tsepamisa maikutlo le ho tsepamisa mohopolo. E boetse e ama khokahano ea makoloi. Batho ka bomong le Lefu la Parkinson ho ba le maemo a tlase a dopamine.
Maemo a dopamine karolong e 'ngoe ea boko e bitsoang dorsal striatum e laola bokhoni ba motho ba ho thabela meputso e kang ho ja. Ho sebetsa hampe ha dorsal striatum moo dopamine e ke keng ea supa bokong hore lijo tse lekaneng li felisitsoe ho ka lebisa ho ts'ebeliso e feteletseng, ho fella ka botenya.
Boemo bo phahameng ba HVA ho hippocampus ea liphoofolo le cortex e ne e amahanngoa le ho fokotseha ha boteng ba Mofuta oa BDNF ka cortex, ho bolelang hore maemo a protheine eo a e hlahisang le ona a fokotsehile. Protheine ena e thusa li-neuron tse teng hore li phele le ho thusa ho hola li-neuron tse ncha. Kantle ho li-neuron tsena, ho ithuta le ho hopola ho ne ho ka ameha.
Bafuputsi ba boetse ba fumane hore ho fa sehlopha litoeba tse ling Ritalin ho khutlisitse tšenyo ea ho ithuta le mohopolo o bakoang ke ho ja lijo tse nang le mafura a mangata. Ho ba fa li-antidepressant Vestra le Norpramin ha hoa ka ha ba le phello mohopolong le ho sitisoa ho ithuta.
References
Kaczmarczyk, M., Machaj, A., Chiu, G., Lawson, M., Gainey, S., York, J., Meling, D., Martin, S., Kwakwa, K., Newman A. Woods, J., Kelley, K., Wang, Y., Miller, M., & Freund, G. (2013). Methylphenidate e thibela phepo e nang le mafura a mangata (HFD) -e khothaletsa ho ithuta / ho holofala ha litoeba tsa bana. Psychoneuroendocrinology DOI: 10.1016 / j.psyneuen.2013.01.004
Stice, E., Spoor, S., Bohon, C., & Nyane, D. (2008). Kamano lipakeng tsa botenya le karabelo e sa bonahaleng ea lijo nakong ea lijo li laoloa ke TaqIA A1 Allele Mahlale, 322 (5900), 449-452 DOI: 10.1126 / science.1161550
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