Neurochem Res. 2014 May;39(5):815-24. doi: 10.1007/s11064-014-1274-6
Ahmed S1, Kashem MA, Sarker R, Ahmed EU, Hargreave GA, McGregor KE.
inahaneloang
Ho nona ke bothata ba bophelo bo botle ba kajeno bo atileng. Lebaka le leng le ka bakang botenya ke tahlehelo ea taolo ea tšebeliso ea lijo tse matlafatsang haholo, mohlomong e le ho shebisisa mekhoa e kenelletseng tlatsong ea lithethefatsi. Ka hona, striatum e kanna ea ba karolo e ka sehloohong ea neural e kenyelletsang takatso ea lijo le lithethefatsi.
Re qhekelletse mona hore ho pepesetsoa tharollo ea nako e telele ea 10% ho ka baka li-neuroadaptations ho striatum tse ananang le tseo ho neng ho tlalehiloe kamora ho pepesetsoa joala kapa lithethefatsi tsa boithabiso. Liroto tsa Male Wistar li ne li fuoe phihlello ea 10% sucrose tharollo (ho ekelletsa ho tloaelehileng la lab chow le metsi a pompo) bakeng sa likhoeli tsa 8 mme li ne li bapisoa le likhoto tsa taolo ha li fuoe phihlello ea sucrose. Likhoto sehlopheng sa sucrose ka tloaelo li nooa ho feta 100 ml ea tharollo ea sucrose ka letsatsi mme li bonts'itse 13% boima ba mmele ho feta taolo qetellong ea likhoeli tsa 8.
Meetso ea Striatal dopamine (DA) e ne e fokotsehile ho likhakanyo tsa sehlopha sa sucrose tse amanang le taolo. Polelo e arohanang ea liprotheine tsa 18 e ile ea bonts'oa seterekeng sa likhoto tsa sehlopha sa sucrose tse amanang le taolo.
Liprotheine tse laoloang tlase li ne li kenyelletsa pyridoxal phosphate phosphatase, e amehang ho synthet ea DA, le phetisetso ea glutathione, e kenyang letsoho ho hlokofatseng mahala. Liprotheine tse laoloang li kenyellelitse prolactin (e tlasa taolo e mpe ea DA) le protheine e amanang le adipose, e amehang bophatlalatsong ba mafura.
Re kholoa taba ea hore neuroadaptations e amanang le DA maemong a bakoang ke ho ja nako e telele ea boipoaro e ka etsa hore ho natefeloa lijo le ho batla lijo tse matlafatsang, ka mokhoa o ts'oanang le o lemalloang ke lithethefatsi le joala.
PMID: 24634252
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