Behav Brain Res. 2017 Jul 14; 330: 46-55. Doi: 10.1016 / j.bbr.2017.05.014.
Camacho A1, Montalvo-Martinez L2, Cardenas-Perez RE2, Fuentes-Mera L3, Garza-Ocañas L4.
inahaneloang
Litloaelo tsa maemo a lijo tse nang le maemo a mangata li hloka polasetiki ea "glutamatergic neurotransication" tsamaisong ea moputso, e kenyang liphetoho liphatlalatsong tsa ho kenyelletsa a-amino-3-hydroxy-5-methylisoxazole 4-propionate receptors (AMPA), N-methyl-d-aspartic acid (NMDA) ) le metabotropic glutamate 2,3 (mGlur 2,3). Leha ho le joalo, karolo ea liphetoho lipakeng tsa li-glutamatergic matsoao a khethollo ea lijo tse matlafatsang tse fumanehang nakong ea nts'etsopele ha e e-so hlalosoe. Mona, re khetholla phello ea lenaneo la phepo e nepahetseng nakong ea gestation ka khetho ea lijo tsa mafura re sebelisa tlhahlobo ea sebaka se ratoang (CPP) le karabelo ea koetliso ea mofani le phello ea eona ho li-marker tsa glutamatergic ho li-nucleus accumbens (Nac) khetla le preortal cortex (PFC). Lintlha tsa rona li bontšitse hore likhoto li bonts'a khetho ea lijo tse nonneng tsa mafura le keketseho ea lijo tse nang le caloric ha li bapisoa le lijo tsa chow. Haholo, 74% ea likhoto tse bonts'ang khetho ea phepelo ea lijo tse mafura a nang le lintlha tse ntle tsa HFD empa 26% e sitiloe ho fumana maemo a HFD. Hape, likhoto tsa banna tse koetlisitsoeng tlasa kemiso ea karabo ea tšebetso ea basebetsi (FR1, FR5 le PR) li bonts'a lihlopha tse arabelang holimo le tse tlase ho sebeletsa lijo. Haholo-holo, lenaneo la phepo e matla ea "hypercaloric" le bakang likhoele tsa basali le lebisa ho matlafatsong ea bana ba basali ka ho bapisoa le bana ba tsoang lijong tsa chow. Kamora nako, re fumane hore karabelo ea mosebetsi e sebetsang ho li-reinforcers tse matlafatsang li lumellana ka ho eketseha ha mGlur 2,3 khetla ea NAc le PFC ea likhoto tsa banna le bana ba basali. Hape, re fumane boikhethelo ba Nr1 bo ikhethileng ka polokelong ea NAc le PFC ea bana ba basali. Lintlha tsa rona li fana ka maikutlo a hore lenaneo la phepo e nepahetseng ka ho ja lijo tse nang le hypercaloric li lebisa ho tšusumetso ea ts'usumetso ea ho sebeletsa lijo le phetoho ea polasetiki ea sistimi tsamaisong ea mesolimbic.
LINKOTSO: Tlatsetso; Sebaka se khethiloeng sa sebaka; Lijo tse phahameng tsa mafura; Li-bokella tsa nyutlelie; mGlur2,3
PMID: 28487223
DOI: 10.1016 / j.bbr.2017.05.014
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