Ho fokotseha ho bokella dopamine linthong tsa Sprague-Dawley tse tloaelehileng ho ja lijo tse nang le mafura a mangata (2010)

Physiol Behav. 2010 Oct 5; 101 (3): 394-400. Doi: 10.1016 / j.physbeh.2010.07.005.

Rada P1, Bocarsly ME, Baaon JR, Hoebel BG, Leibowitz SF.

inahaneloang

Batho ba mafura a mangata le liphoofolo ba bonts'a ts'ebetso ea sisteme ea dopamine (DA) ho li-nucleus accumbens (NAc). Potso e botsitsoeng mona ke hore na phetoho ena ho NAc DA e ka fumanoa ho likhoto tsa Sprague-Dawley tse tloaetseng ho nona haholo lijong tse nang le mafura empa li le boima ba 'mele bo tloaelehileng. Likhoto li ne li arotsoe ka sehlopha sa "botenya" kapa "ho thibela botenya" (OR), ho ipapisitse le boima ba 'mele nakong ea matsatsi a 5 a ho fumana lijo tse nang le mafura a mangata, ebe li fetisetsoa lijong tsa mafura a tlase pele ho etsoa liteko tsa microdialysis.

Likhoto tsa OP ha li bapisoa le likhoto tsa OR tse bonts'itsoeng haholo li fokolitse maemo a basotho a DA ho NAc. Kamora lijo tse phephetsang tse nang le mafura a mangata, litonki tsa OP le OR ka bobeli li bonts'itse keketseho e kholo ho DA ea kantle ho naha le metabolites ea eona; le ha ho le joalo, NAc DA ea likhoto tsa OP e ntse e le maemong a fokotsehileng. Hape, keketseho ea litekanyetso tsa DA le metabolite tse bonoang ho litoeba tsa OR kamora taolo ea tsamaiso ea emulsion ea mafura e ne e sa bonahale ho litoeba tsa OP, tseo ho fapana le moo li sa bonts'eng phetoho ho DA le ho fokotseha ha metabolites ea eona. Liphetho tsena li bontša hore mafura a ka susumetsa ho tsoa ha DA, 'me ea bobeli, ea hore likhoto tse tsoakiloeng li tloaetse ho nona haholo le ho nona ka mokhoa o monate oa ho ja lijo tse nang le mafura tse ngata tse fokotsitseng ho supa tsamaisong ea mesolimbic DA ha li ntse li le boima bo tloaelehileng, li fana ka maikutlo a hore e kanna ea amana ka boomo le boits'oaro ba bona ba ho fetella ka mokhoa o feteletseng.

LINKOTSO: Intralipid; mafura; botenya khatello ea botenya rat; triglycerides

PMID: 20643155

PMCID: PMC2930885

DOI: 10.1016 / j.physbeh.2010.07.005

Free Article PMC Article