LIPOTSO: Bopaki bo eketsehileng ba ho lemalla lithethefatsi le bokhoba ba litekanyetso tsa boitšoaro bo ama tsela le methapo e tšoanang ea kelello.
La 14 Loetse 2012 ho Psychology & Psychiatry
Bafuputsi Lefapheng la Lipatlisiso la Thepsps hRe fumane likhokahano tse ncha lipakeng tsa protheine e laolang takatso ea rona ea ho ja le lisele tsa boko tse kenyelletsang kholisong ea joala. Se sibolotsoeng se supa menyetla e mecha ea ho qapa lithethefatsi ho phekola bokhoba ba joala le bokhoba bo bong.
Boithuto bona bo bocha bo hatisitsoeng marang-rang pele bo hatisoa ke koranta ea Neuropsychopharmacology, bo shebana le peptide ghrelin, e tsejoang ho hlohlelletsa lijo.
“Ena ke thuto ea pele ea ho tšoaea litlamorao tsa ghrelin ho li-neuron sebakeng sa boko se bitsoang nko ea bohareng ba amygdala, "Ho boletse moetapele oa sehlopha sa Scripps Research Institute Associate Professor Marisa Roberto, ea ileng a koeteloa selemong se fetileng ke Rephabliki ea Italy ka mosebetsi oa hae lefapheng la tahi. “Ho na le bopaki bo ntseng bo eketseha ba hore litsamaiso tsa peptide tse laolang tšebeliso ea lijo le tsona ke karolo ea bohlokoa ts'ebelisong e mpe ea joala. Litsamaiso tsena tsa peptide li ka sebetsa e le sepheo sa liphekolo tse ncha tse reretsoeng ho phekola bokhoba ba tahi. ”
Tšebeliso e ngata ea joala le bokhoba ba tahi bo baka liperesente tse ka bang 4 tsa lefu lefatšeng ka bophara selemo se seng le se seng. United States, seo se fetolela lefu la 79,000 selemo le selemo le $ 224 limilione tse likete tse tlhokomelong ea bophelo bo botle le litšenyehelo tse ling tsa moruo, ho latela tlaleho ea 2011 e fanoeng ke Centers for Disease Control and Prevention.
Lebatooa la Brain
Sebaka sa boko se tsejoang ka hore ke khubu ea konokono ea amygdala ho nahanoa hore ke karolo ea bohlokoa phetohong ea ts'ebeliso ea lino tse tahang, ke hore, phetoho ea likokoana-hloko e tsoang ho ho ba le maikutlo a monate mabapi le tšebeliso ea joala ho fihlela tlhoko ea ho sebelisa joala ho itlosa bolutu. , maikutlo a fosahetseng ka lebaka la ho se sebelisoe ha eona. Ho liphoofolo tse lemaletseng joala, matla a mantlha a taolo ea amygdala a eketsehile haholo.
"Ka lebaka la bohlokoa ba khubu ea mantlha ea amygdala ts'ebetsong ea joala, re ne re batla ho leka litlamorao tsa ghrelin sebakeng sena,”Ho boletse Maureen Cruz, mongoli oa pele oa boithuto le molekane oa mehleng oa lipatlisiso ho laboratori ea Roberto, eo hona joale e leng molekane ho Booz Allen Hamilton, Rockville, MD.
The peptide ghrelin e tsebahala haholo ka ho susumetsa ho ja ka ketso ea eona ho receptor e tsejoang e le GHSR1A ho hypothalamus tikoloho ea boko. Empa boramahlale ba ne ba sa tsoa bonts'a hore bofokoli ba liphatsa tsa lefutso ka bobeli ghrelin le receptor ea GHSR1A li ne li amahanngoa le linyeoe tse matla tsa joala mefuteng ea liphoofolo. Ntle le moo, bakuli ba tahi ba na le maemo a phahameng a ghrelin peptide e potolohang maling a bona ha a bapisoa le bakuli bao e seng joala. Mme, ha maemo a ghrelin a phahama, bakuli ba tlaleha litakatso tsa joala.
Bopaki bo Bocha
Boithutong bo bocha, Roberto, Cruz, le basebetsi mmoho le ba bang ho tsa lipatlisiso tsa mahlale a Jeremane Research le Univesithi ea Oregon Health le Science, ba bonts'itse hore GHSR1A e teng ka li-neuron bokong bo bohareng ba amygdala bokong ba rat.
U sebelisa mekhoa ea ho rekota e kenelletseng, sehlopha se ile sa lekanya hore na matla a li-synapses tsa GABAergic (sebaka se pakeng tsa methapo ea kutlo e fetisang inhibitory neurotransmitter GABA) se ile sa fetoha joang ha ho ne ho sebelisoa ghrelin. Ba fmoea o moholo o ileng oa baka phetiso e matla ea GABAergic methapong ea methapo ea kutlo ea amygdala. Ha ho etsoa liteko tse ling, bo-rasaense ba hlokometse hore sena se ka etsahala hore ebe sena se bakiloe ke ho lokolloa ha neurotransmitter ea GABA.
Ka mor'a moo, bafuputsi ba ile ba thibela receptor ea GHSR1A ka inhibitor ea lik'hemik'hale mme ba lekanya ho fokotseha ha phetisetso ea GABA. Sena se senotse ts'ebetso ea tonanahali, kapa e tsoelang pele, ea ghrelin methapong ena ea methapo.
Khethong ea hoqetela ea lipatlisiso, bafuputsi ba ile ba hlahloba li-neuron ho tsoa lithethefatsing tsa joala le ho laola likhoto ha ho eketsoa ghrelin le ethanol. Taba ea pele, bo-ramahlale ba ile ba eketsa ghrelin e lateloang ke ethanol. Sena se hlahisitse keketseho e matla le ho feta ea likarabo tsa GABAergic litsing tsena tsa methapo ea kutlo. Leha ho le joalo, ha bo-ramahlale ba khutlisa taelo eo, ba eketsa ethanol pele le ghrelin ea bobeli, ghrelin ha ea ka ea eketsa phetiso ea GABAergic. Thae o fana ka maikutlo a hore ghrelin e ka baka litlamorao tsa joala mothapong o bohareng oa amygdala, ha e le hantle, e priming ea sistimi.
Menyetla e mecha
Roberto o itse: "Liphetho tsa rona li supa mekhoa e arolelanoeng le e fapaneng e amehang litlamorao tsa ghrelin le ethanol bohareng ba amygdala." “Habohlokoa, ho na le lets'oao la tonne ghrelin le bonahalang le sebelisana le litsela tse kentsoeng ke ho pepeseha ha ethanol e matla le e sa foleng. Mohlomong haeba re ka fumana mokhoa oa ho thibela tšebetso ea ghrelin sebakeng sena, re ka fokotsa kapa ra tima litakatso tse tahiloeng ke makhoba a tahi. ”
Leha ho le joalo, Roberto o hlokomelisa hore mekhoa ea phekolo ea joala ea kajeno e sebetsa feela ho bakuli.
O re: "Hobane joala bo ama litsamaiso tse ngata bokong, ho ke ke ha ba pilisi e le 'ngoe e tla folisa likarolo tse ngata le tse rarahaneng tsa lefu lena." "Ke ka hona re ithutang bokhoba ba tahi ka mahlakore a fapaneng, ho utloisisa sepheo se fapaneng sa boko se amehang."
Lintlha tse ling: "Ghrelin e eketsa phetisetso ea GABAergic mme e sebelisana le liketso tsa Ethanol ho Rat Central Nucleus ea Amygdala," www.nature.com/npp. EA-012190a
E fanoe ke Setsi sa Lipatlisiso saHTML
Bo-rasaense ba bontša protheine e amanang le tlala hape e amehang bokhobeng ba tahi. ” Loetse 14th, 2012. http://medicalxpress.com/news/2012-09-scientists-protein-linked-hunger-implicated.html
Posted ke
Robert Karl Stonjek
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