Eur Neuropsychopharmacol. 2017 Oct 9. pii: S0924-977X (17) 30932-X. Doi: 10.1016 / j.euroneuro.2017.09.007.
Majuri J1, Joutsa J2, Johansson J3, Voon V4, Parkkola R5, Alho H6, Arponen E3, Kaasinen V7.
inahaneloang
Litla-morao tsa boitšoaro, joalo ka ho becha ha methapo ea kutlo (PG) le bothata ba ho ja ka mokhoa o feteletseng (BED), li bonahala li amana le liphetoho tse ikhethang ho ts'ebetso ea dopamine ea boko le ts'ebetso ea opioid, empa karolo ea lits'ebetso tse ling tsa neurotransmitter ha e hlake. Ha re fuoa karolo ea bohlokoa ea serotonin maemong a mangata a mafu a kelello, re ne re ikemiselitse ho bapisa ts'ebetso ea serotonergic har'a batho ba nang le BED, PG le taolo e phetseng hantle. Bakuli ba supileng ba BED, bakuli ba 13 PG le li-taolo tse phetseng hantle tsa 16 ba ile ba hlahlojoa ka sephetho se phahameng sa qeto ea positron emission tomography (PET) ba sebelisa serotonin transporter (SERT) tracer [11C] MADAM. Ho ile ha etsoa liphuputso ka bobeli ba khahleho le tsa bohlale ba bokahare. Bakuli ba nang le bethe o ile a bontša e ile ea eketseha SERT tlama ka libaka parieto-occipital cortical bapisoa bobeli PG le laola bophelo bo botle, le fokotseha e tšoanang le ka ho kopanya ka khubung ea accumbens, tlaasana ya ntango gyrus le lateral orbitofrontal cortex. Ha ho phapang pakeng tsa bakuli ba PG le taolo e ileng ea bonoa. Ha ho le e 'ngoe ea lithuto e neng e le lingakeng tsa SSRI ka nako ea ho nahana,' me ho ne ho se na phapang maemong a khatello ea maikutlo pakeng tsa bakuli ba PG le BED. Liphetho li totobatsa phapang lipakeng tsa boko tsa SERT pakeng tsa batho ba nang le BED le PG mme li fana ka bopaki bo bong ba likeletso tse fapaneng tsa neurobiological lithutong tsa boits'oaro tse sa amaneng le tlholeho e teng pakeng tsa maikutlo. Liphetho li thusa molemong oa kutloisiso ea litheko tsa boits'oaro ka ho bonahatsa liphetoho tse tlisoang ke serotonin le ho fana ka moralo oa lithuto tse ling ho hlahloba kalafo e ikhethang ea litlhare.
LINKOTSO: Ho itlopa lijo; Ho becha ka tsela ea tlhaho; Positron emission tomography; Serotonin; Serotonin transporter; [(11) C] MADAM
PMID: 29032922
DOI: 10.1016 / j.euroneuro.2017.09.007
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