Setsi sa Metab. 2015 Nov 18. pii: S1550-4131(15)00525-2. doi: 10.1016/j.cmet.2015.10.009.
Han W1, Tellez LA2, Niu J3, Medina S4, Ferreira TL5, Zhang X6, Su J7, Tong J8, Schwartz GJ9, van den Pol A6, de Araujo IE10.
inahaneloang
Ho fokotseha ka khalori ho kenya letsoho haholo bakeng sa liphello tse ntle tsa opereishene ea bariatric. Leha ho le joalo, mekhoa ea boipheliso e amanang le ho khutlisetsoa ha pampiri ea moriana ho fokotseha ha litakatso tsa tsoekere e ntse e sa tsitsa. Re bontša hore ho kenngoa ha diodenal-jejunal overpass (DJB) ho thibela takatso e monate ea maladaptive ka ho etsa litšebeletso tsa dopamine tse amohelehang. DJB e senya bokhoni ba ts'ebetso ea tsoekere e tloaelehileng e le ho khothaletsa takatso e monate ho liphoofolo tse sate, kahoo e senola kamano pakeng tsa tsoekere e tloaelehileng ea tsoekere le ho ja lijo tse monate. Ho fapana le ho kenngoa ha k'halori e tlaase, ho kenngoa ha tsoekere ho ne ho amahanngoa le li-dopamine tse fokolang tsa dorsal striatum, tse nang le likokoana-hloko tse hlahisang boloetse bo bongata ho feta ho tsoaloa ha li-dopamine ho feta li-jejunal infusions tse tšoanang. Ka ts'ebetsong, ts'ebetso ea optogenetic ea lisele tsa dopamine-tse tsitsitseng tsa storum e lekaneng e ne e lekane ho tsosolosa takatso e monate ea maladaptive mantlha a DJB a sate. Liphuputso tsa rona li supa kamano e hlakileng pakeng tsa pontšo ea lefu la dopamine le liphello tsa mehato ea bariatric.
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