Tšebeletso ea botšepehi pakeng tsa taolo ea batsamaisi le meputso ea libaka tsa boko e bolela esale pele lekholong la mafura a 'mele ho batho ba sa foleng dieters (2016)

Tsebo ea kelello ea kelello
 

Pin-Hao Andy Chen, Robert S. Chavez & Todd F. Heatherton

Maqephe 1-5 | E amohetse 19 Apr 2016, E amohetse 05 Sep 2016, Mofuta oa sengoli o amohetsoeng inthaneteng: 23 Sep 2016, E phatlalalitsoe inthaneteng: 11 Oct 2016

inahaneloang

Ho sitoa ho boloka boima ba 'mele bo phetseng hantle ho ka bonts'a ho se leka-lekane ha nako e telele lipakeng tsa taolo e phahameng le tsamaiso ea moputso oa kelello. Boithuto ba hajoale bo ile ba hlahloba hore na khokahano ea anatomical pakeng tsa litsamaiso tsena tse peli e boletse esale pele phapang ea motho ka mong ho fihlela boima ba 'mele bo phetseng hantle, haholoholo ho bo-ja lijo tse sa foleng. Basebetsi ba fepa ba sa foleng ba basali ba mashome a mararo a metso e ts'eletseng ba phethile mosebetsi oa ho kopitsa lijo bakeng sa senepe. Libaka tse peli-tsa-thahasello (ROI) li ne li hlalositsoe ho tsoa mosebetsing oa ho boela o sebetsa: the low frontal gyrus (IFG), e sebelisang taolo ea kelello le orbitof Pambal cortex (OFC), e emelang boleng ba moputso. Ho ile ha bonoa pampitšana e tšoeu e hokahanyang li-ROI tsena ka bobeli ba sebelisang tšebeliso ea kelello (DTI) le tractography ea probabilistic. Liphetho li bonts'itse kamano e mpe lipakeng tsa liperesente tsa mafura a mmele le nnete ea taba e tšoeu kahara pampitšana e khethiloeng. Sena se fana ka maikutlo a hore ho fokotsoa hoa ts'ebetso lipakeng tsa OFC le IFG ho ka amana le mathata a ho itaola bakeng sa ba jang ka thata ho laola boima ba 'mele.

LINKOTSO: Boitaolo, monahano o tenang, Kgokahano, litšoantšo tse sebetsang ka matla a motlakase, phapang ea motho ka mong, botenya

Selelekela

Botenya le phepo e nepahetseng li eketsehile haholo lilemong tse mashome tsa morao tjena, ha li-dieters tse ngata li hloleha ho theola boima ba 'mele ka nako e telele le ho ba li-dieters tse sa foleng (Andreyeva, Long, Henderson, & Grode, 2010 Andreyeva, T., Nako e telele, MW, Henderson, KE, & Grode, GM (2010). Ho leka ho theola boima ba 'mele: Maano a ho ja har'a Maamerika a nang le botenya kapa botena ka 1996 le 2003. Sengoloa sa American Dietetic Association, 110 (4), 535-542. Doi: 10.1016 / j.jada.2009.12.029[CrossRef], [Lebokose]). Har'a batho bana, ba bang ba tsoela pele ho nona le ho feta kamora lilemo tsa ho itima lijo (van Strien, Herman, & Verheijden, 2014 van Strien, T., Herman, CP, & Verheijden, MW (2014). Thibelo ea lijo le phetoho ea boima ba 'mele. Boithuto bo latelang ba lilemo tse 3 ho sampole ea moemeli oa Sedache. Takatso ea lijo, 76, 44-49. Doi: 10.1016 / j.appet.2014.01.015[CrossRef], [Lebokose], [Websaete ea Science ®]), ka hona re etsa boits'oaro bo nyenyefatsang lipheo tsa bona. Tlhatlhobo e felletseng ea botenya e fana ka maikutlo a hore ha se feela ho phahamisa moputso ho utloisisang lijo empa ho hloleha ho itlhophisa ho boetse ho na le seabo ho nona haholo (Volkow, Wang, Tomasi, & Baler, 2013 Volkow, ND, Wang, G.-J., Tomasi, D., & Baler, RD (2013). Botenya le ho lemalla: Neurobiological overlaps. Tlhahlobo ea botenya, 14(1), 2–18. doi:10.1111/j.1467-789X.2012.01031.x[CrossRef], [Lebokose], [Websaete ea Science ®]). Ka mokhoa o ts'oanang, liphapang tsa motho ka mong ho fihlela kapa ho boloka katleho ea nako e telele ea ho ja li ka bontša phapang bokhoni ba ho itaola (Heatherton, 2011 Heatherton, TF (2011). Neuroscience ea ho itaola le ho itaola. Tlhahlobo ea Selemo le Selemo ea Psychology, 62 (1), 363-390. Doi: 10.1146 / annurev.psych.121208.131616[CrossRef], [Lebokose], [Websaete ea Science ®]). Ho latela mofuta oa tekatekano, liphetho tse joalo tsa boitaolo li bonts'a phapang ea motho ka mong ho se leka-lekana lipakeng tsa libaka tsa boko tse amehang taolong ea phethahatso, mohlala, gyrus e ka tlase e ka pele (IFG) le libaka tse emelang boleng ba moputso, mohlala, orbitofrontal cortex (OFC) (Heatherton & Wagner, 2011 Heatherton, TF, & Wagner, DD (2011). Temoho ea methapo ea kutlo ea ho itaola. Mekhoa ea Mahlale a Kelello, 15 (3), 132-139. Doi: 10.1016 / j.tics.2010.12.005[CrossRef], [Lebokose], [Websaete ea Science ®]). Tekatekano lipakeng tsa moputso le taolo e ipapisitse le puisano lipakeng tsa IFG le OFC (Wagner, Altman, Boswell, Kelley, & Heatherton, 2013 Wagner, DD, Altman, M., Boswell, RG, Kelley, WM, & Heatherton, TF (2013). Ho felloa ke taolo ho ntlafatsa likarabo tsa methapo ho meputso le ho sitisa taolo ea holimo holimo. Setsebi sa Mahlale, 24 (11), 2262-2271. Doi: 10.1177 / 0956797613492985[CrossRef], [Lebokose], [Websaete ea Science ®]), e bonahatsang khokahano e lipakeng tsa bona. Phapang e le 'ngoe boits'ebetsong ba mekhoa ena ea "anatomical pathways" e ka bolela sephetho sa nako e telele sa phepo e nepahetseng, joalo ka liperesente tsa mafura a mmele.

Bakeng sa ho arola libaka tsa boko tse tsejoang hore li kentse letsoho ho sebetsaneng le boleng ba phepo ea lijo, re sebelisitse mosebetsi oa ho khutlisa lijo ho fumana libaka tsa IFG le OFC tsa lithahasello (ROI) ka ho sebelisa litšoantšo tsa magnetic resonance imaging (fMRI) . Litlhahlobo tsa patlisiso ena li bonts'a hore li-dieters tse sa foleng li na le tšekamelo ea ho fetelletsa litaba ho lijo tse matlafatsang libakeng tsohle tsa meputso le libaka tse amehang taolong ka mor'a ho pepesetsoa maemo a amanang le ho hloleha ha lijo lefatšeng la 'nete, joalo ka ho ja lijo tse nang le likhalori tse ngata kapa ho Ba felletsoe ke taolo ea bona ea kutloisiso (Kelley, Wagner, & Heatherton, 2015 Kelley, WM, Wagner, DD, & Heatherton, TF (2015). Ha a batla sistimi ea motho ea ho itaola. Tlhahlobo ea selemo le selemo ea Neuroscience, 38(1), 389–411. doi:10.1146/annurev-neuro-071013-014243[CrossRef], [Lebokose], [Websaete ea Science ®]; Volkow et al., 2013 Volkow, ND, Wang, G.-J., Tomasi, D., & Baler, RD (2013). Botenya le ho lemalla: Neurobiological overlaps. Tlhahlobo ea botenya, 14(1), 2–18. doi:10.1111/j.1467-789X.2012.01031.x[CrossRef], [Lebokose], [Websaete ea Science ®]). Kahoo, re sebelisitse mosebetsi oa ho kopanya lijo le ho tseba ho ntlafatsa libaka tsa IFG le OFC tse kenyelletsang ts'ebetsong ea lijo, 'me re sebelisa libaka tsena tse peli e le limmapa tsa peo bakeng sa tlhahlobo ea litaba ea bohlanya (DTI) tlhahlobisong. lekola boteng ba litaba tse tšoeu lipakeng tsa libaka tsena tse peli. Morero oa thuto ena e ne e le ho sebelisa mekhoa e mengata haholo ho khetholla lipampitšana tsa litaba tse tšoeu lipakeng tsa libaka tse hlalositsoeng hantle tsa IFG le OFC. Mokhoa ona o fana ka mokhoa o shebiloeng oa ho lekola hore na ts'ebetso ea ts'ebetso ea pampitšana ee e bolela ho fokotseha ha phepo e matla ho liperesente tsa mafura a mmele. Re ile ra nahana hore batho ba jang lijo tse sa foleng ba neng ba e-na le peresente e ngata ea mafura a mmele ba ne ba tla bonts'a bots'epehi bo tlase seterekeng se hokahanyang IFG le OFC.

mekhoa

Li-dieters tse mashome a mane tse nang le letsoho le letona tsa basali ba sa foleng ba fumaneng tse fetang 15 ho Restraint Scale, tekanyo ea phepo e sa foleng (Heatherton, Herman, Polivy, King, & McGree, 1988 Heatherton, TF, Herman, CP, Polivy, J., King, GA, & McGree, ST (1988). Tekanyo ea (mis) ea thibelo: Tlhatlhobo ea litaba tsa mohopolo le psychometric. Journal ea Psychology e sa tloaelehang, 97(1), 19–28. doi:10.1037/0021-843X.97.1.19[CrossRef], [Lebokose], [Websaete ea Science ®]), ba ile ba hiroa thutong ena ho tsoa sampoleng e kholo ea baithuti ba koleche. Barupeluoa ba ile ba hlahlojoa hore ba se ke ba ba le nalane ea metabolic, kelello kapa methapo. Barupeluoa ba bane ba ile ba qheleloa ka thoko ka lebaka la ho sisinyeha ha hlooho ka mokhoa o fetelletseng (ho feta 3 mms ka x-, y-, kapa z-tataiso) nakong ea ho sekena, ho fella ka boholo ba sampole ea li-dieters tse sa foleng tsa 36. Dieter li ne li lekanngoa ho sebelisoa sekala sa Tanita (mohlala oa TBF-300A Arlington Heights), e netefalitsoeng hore e lekanya liperesente tsa mafura a 'mele. Har'a li-dieters tse sa foleng, liperesente tsa mafura a 'mele e ne e le 29.6% (SD = 5.5%; range = 16.6-38.2%)' me boima ba 'mele (BMI) e ne e le 23.9 (SD = 3.1%, range = 17.2-33.7, Tafole 1) .

Tafole 1. Palo ea baahi le ea ho ja.

CSVHlahisa Letlapa

Bakeng sa ho tsebisa IFG le li-ROC tsa li-OFC tse amehang ts'ebetsong ea tlhahiso ea lijo, re sebelisitse paradigm ea tlhahiso ea lijo e le mosebetsi oa lehae. Pele ho mosebetsi ona oa localizer, re ne re sebelisa mosebetsi o fokotsang taolo ea thibelo, kaha mosebetsi ona o thusa mosebetsi oa moputso o matla (Wagner et al., 2013 Wagner, DD, Altman, M., Boswell, RG, Kelley, WM, & Heatherton, TF (2013). Ho felloa ke taolo ho ntlafatsa likarabo tsa methapo ho meputso le ho sitisa taolo ea holimo holimo. Setsebi sa Mahlale, 24 (11), 2262-2271. Doi: 10.1177 / 0956797613492985[CrossRef], [Lebokose], [Websaete ea Science ®]). Mosebetsing ona oa taolo e thibelang ho felloa ke matla, bankakarolo ba ile ba kopuoa ho shebella video ea 7-min mabapi le linku tse kholo tsa Canada tse nang le letoto la mantsoe a khelosang a tlohang tlase ho ea bohareng ba skrini ka 3 s (mantsoe a 40 ka botlalo). Barupeluoa ba laetsoe ho qoba ho bala mantsoe a khelosang mme ba shebane feela le ho shebella video. Hang kamora mosebetsi o felisang oa thibelo ea thibelo, barupeluoa ba ile ba amohela mosebetsi oa ho ts'oara lijo hape. Mosebetsi ona o ne o na le litšoantšo tse 90 tse khahlang tsa lijo le tse ling tse 180 tse amang batho kapa litšoantšo tsa tlhaho e le litšoantšo tsa taolo. Setšoantšo ka seng se hlahisitsoe bakeng sa 2000 ms 'me se lateloa ke ho hlophisoa bakeng sa li-ms tse ling tse 500 ka moralo o amanang le ketsahalo. Barupeluoa ba ile ba laeloa ho etsa kahlolo ea kahare / kantle bakeng sa setšoantšo ka seng ka ho tobetsa likonopo. Mosebetsi ona oa kahlolo o entse hore barupeluoa ba tsepamise maikutlo a bona mosebetsing ona ba sa tsebe sepheo sa rona sa ho ithuta, e neng e le ho beha libaka tsa boko bo arabela lijong.

Lintlha tsa fMRI tse tsoang mosebetsing oa ho hlophisa lijo hape li ile tsa ntlafatsoa tsa ba tsa hlahlojoa ka SPM8 (Lefapha la Chelete ea Cognitive Neurology, London, England). Lits'ebetso tsa ts'ebetso esale pele li kenyelletsa khalemelo ea motsamao, ho hlophisa boteng, ho sa rate, ho tloaela sebaka se tloaelehileng, le 6-mm ka bophara bo felletseng ka halofo e phahameng (FWHM) Gaussian kernel smoothing (bona Lisebelisoa tsa tlatsetso bakeng sa litlhaloso tse qaqileng tsa litekanyetso tsa ho lekola tsa fMRI). Bakeng sa motho e mong le e mong ea nkang karolo, mohlala o akaretsang o kenyelletsang litlamorao tsa mesebetsi le li-covariate tse se nang thahasello li ile tsa kenngoa mme oa khothatsoa ka ts'ebeliso ea "canonical hemodynamic reaction function" (HRF). Litšoantšo tse fapaneng le taolo ea taolo ea lijo li ile tsa etsoa bakeng sa karolo e 'ngoe le e' ngoe ebe li kenngoa tlhahlobisong e sa sebetseng ea kelello eohle, e lokisitsoeng bakeng sa papiso e ngata p <0.05 le lipapiso tsa Monte Carlo tse sebelisang AlphaSim ea AFNI (Figure 1 (a), Lethathamo la S1). IFG le OFC ROIs li hlalositsoe ho ipapisitsoe le tlhahlobo ea kelello eohle 'me li sebelisoa e le limaske (Setšoantšo sa 1 (b)) ka mokhoa oa peo ea mask a mabeli ka DTI probabilistic tractography. Lintlha tsa DTI li ile tsa ntlafatsoa tsa ba tsa hlahlojoa ka Diffusion Toolbox ho FSL (Behrens et al., 2003 Behrens, T., Woolrich, MW, Jenkinson, M., Johansen-Berg, H., Nunes, RG, Clare, S.,… Smith, SM (2003). Sebopeho le phatlalatso ea ho hloka botsitso litšoantšong tse boima tsa MR. Reselance ea Magnetic ho Bongaka, 50 (5), 1077-1088. Doi: 10.1002 / mrm.10609[CrossRef], [Lebokose], [Websaete ea Science ®]). Re sebelisitse mokhoa oa peo ea limaske tse peli ho netefatsa hore limmapa tsa tractography li kenyeletsa feela melapo e fetang har'a limmapa ka bobeli. Mabapi le li-flowlines tsa 5000 tsa transabilistic pampiri e rometsoeng e tsoa ho voxel e 'ngoe kahare ho limaske tsa peo ka bobeli' me liphetho tsena li ile tsa hlophisoa sebakeng se tloaelehileng sa Montreal Neurological Institute. Bakeng sa ho khetholla 'mapa o tloaelehileng oa tractography har'a batho ka bomong, liphetho tsa motho ka mong tsa tractography li ile tsa hlakoloa mme tsa koaheloa le ba bang kaofela ho theha' mapa oa monyetla oa sehlopha. Ho etsa roboto ea 'mapa oa tractography, e ne e ts'oaroa ka tekano ea monyetla oa pampitšana ea 50% ho barupeluoa bohle ba sebakeng se tloaelehileng (Setšoantšo sa 1 (c)). 'Mapa ona o tloaelehileng oa tractography o ne o manehiloe holim'a setšoantšo sa motho e mong le e mong oa sebapali (FA) (tekanyo e akaretsang ea boits'oaro bo tšoeu kapa tšebelisano) le boleng ba FA li nkuoe ho li-voxels tsohle ka har'a' mapa ona oa tractography. Bakeng sa morupeluoa e mong le e mong, ho ile ha baloa palo ea FA e emeloang ho emela taba e tšoeu. Lilemo tsa barupeluoa, BMI, le lintlha tsa FA li ile tsa nkuoa e le lintho tse ikemetseng tlhahlobisong e khutšoanyane ea khatello le liperesente tse mafura a 'mele e le phapanyetsano e itšetlehileng, ho hlahloba hore na liphapang tsa' nete tse tšoeu li bontšitse katleho ea nako e telele boitekong.

Setšoantšo sa 1. (a) Morero oa phetisetso ea lijo tsa cue facara fMRI e khothalelitse ts'ebetso libakeng tsa OFC le IFG, e lumellana le liphetho tsa pejana ka har'a lingoliloeng. (b) Litereke tsa OFC le IFG tse tsoang tlhahlobisong ea fMRI li ile tsa sebelisoa ka nako eo e le limaske tsa peo bakeng sa tlhahlobo ea DTI probabilistic tractography. (c) Ho tsoa tlhahlobisong ea DTI, re ntan'o hlakola tsela e tšoeu e pakeng tsa IFG le OFC, e neng e ts'oana ka linako tsohle. Bothata ba taba e tšoeu bohareng ba tsela ena bo ne bo kopantsoe le mafura a 'mele oa motho e mong le e mong. (d) Boleng ba FA bo ntšitsoeng pampitšaneng ea IFG-OFC e bonts'itse khokahano e mpe le liperesente tsa mafura a mmele (sebaka se soeufalitsoeng se emela karohano ea kholiseho ea 95%).

Slide sa PowerPointOriginal jpg (93.00KB)Bontša boholo bo feletseng

Results

Liphetho tsa FMRI tse tsoang mosebetsing oa ho etsa lijo hape li senotse hore IFG le OFC li bonts'itse ts'ebetso e kholo bakeng sa lijo ho feta litšoantšo tse laoloang (Figure 1 (a)Tafole S1), e tsamaellanang le liphuputso tse tsoang lithutong tse fetileng (Lopez, Hofmann, Wagner, Kelley, & Heatherton, 2014 Lopez, RB, Hofmann, W., Wagner, DD, Kelley, WM, & Heatherton, TF (2014). Lits'oants'o tsa Neural tsa ho inehela molekong bophelong ba letsatsi le letsatsi. Setsebi sa Mahlale, 25 (7), 1337-1344. Doi: 10.1177 / 0956797614531492[CrossRef], [Lebokose], [Websaete ea Science ®]; Wagner et al., 2013 Wagner, DD, Altman, M., Boswell, RG, Kelley, WM, & Heatherton, TF (2013). Ho felloa ke taolo ho ntlafatsa likarabo tsa methapo ho meputso le ho sitisa taolo ea holimo holimo. Setsebi sa Mahlale, 24 (11), 2262-2271. Doi: 10.1177 / 0956797613492985[CrossRef], [Lebokose], [Websaete ea Science ®]). Lihlopa tse bakoang ke IFG le OFC tse tsoang tlhahlobisong ea fMRI li sebelisitsoe e le libaka tsa peo bakeng sa DTI probabilistic tractography (Setšoantšo sa 1 (b)). Tlhahlobo ea DTI probabilistic tractography ea li-cross-subject e senotse pampitšana e tšoeu e tšoeu e hokahanyang IFG le letšehali la OFC (Setšoantšo sa 1 (c)). Karolelano ea boleng ba 'nete ka har'a pampitšana ena e bonts'a khokahanyo e mpe e mpe ka liperesente tse ngata tsa mafura a mmele (R₃₆ = -0.379, p = 0.023), ho bonts'a li-dieters tse nang le liperesente tse tlase tsa mafura a 'mele li bonts'itse bots'epehi bo boholo ba taba e tšoeu (Setšoantšo sa 1 (d)). Kamora ho laola lilemo le BMI, litekanyetso tsa FA tse kahara pampitšana li ile tsa tsoela pele ho bonts'a khokahano e mpe haholo le liperesente tsa mafura a 'mele (beta = -0.247, t(35) = -2.862, p = 0.007).

Puisano ka kakaretso

Liphumano tsa rona li ts'ehetsa mohopolo oa hore boteng ba sebopeho lipakeng tsa IFG, sebaka sa bohlokoa ho arabeleng (Aron, 2011 Aron, AR (2011). Ho tloha ho sehlahlo ho isa taolong e sebetsang le e khethang: Ho theha mohlala o motle oa ho emisa likarabo tse sa nepahalang. Likokoana-hloko tsa likokoana-hloko, 69 (12), e55-68. Doi: 10.1016 / j.biopsych.2010.07.024[CrossRef], [Lebokose], [Websaete ea Science ®]) le OFC, sebaka se emelang moputso oa boleng bo phahameng ba lijo (van der Laan, de Ridder, Viergever, & Smeets, 2011 van der Laan, LN, de Ridder, DTD, Viergever, MA, & Smeets, PAM (2011). Tatso ea pele e lula e na le mahlo: Tlhatlhobo ea meta ho li-neural correlates tsa ho sebetsana le lintlha tsa lijo tse bonoang. NeuroImage, 55 (1), 296-303. Doi: 10.1016 / j.neuroimage.2010.11.055[CrossRef], [Lebokose], [Websaete ea Science ®]), E amana le phapang ea motho ka mong liperesente tsa mafura a 'mele, index ea putative ea katleho ea nako e telele lijong tsa ho ja. Ho ipapisitsoe le mofuta oa tekano oa boitaolo (Heatherton & Wagner, 2011 Heatherton, TF, & Wagner, DD (2011). Temoho ea methapo ea kutlo ea ho itaola. Mekhoa ea Mahlale a Kelello, 15 (3), 132-139. Doi: 10.1016 / j.tics.2010.12.005[CrossRef], [Lebokose], [Websaete ea Science ®]), ho hloleha ho itaola ho hlahisa ho se lekane pakeng tsa taolo e phahameng le libaka tsa moputso. Batho ka bomong ba nang le bothata bo fokotsoang ba litaba tse tšoeu kahare ho pampitšana e hokahanyang libaka tsena ba ka ba le katleho e tlase puisanong lipakeng tsa libaka tsena ho feta tse nang le botsitso bo phahameng (Madden et al., 2012 Madden, DJ, Bennett, IJ, Burzynska, A., Sebōpi, GG, Chen, N.KK, & Song, AW (2012). Litšoantšo tse thata tsa ts'oaetso ea taba e tšoeu ea bokong botsofaling ba botsofaling. Biochimica et Biophysica Acta (BBA) - Sesosa sa Mafu a Mafu, 1822 (3), 386-400. Doi: 10.1016 / j.bbadis.2011.08.003[CrossRef], [Lebokose], [Websaete ea Science ®]). Ka puisano e sa sebetseng pakeng tsa taolo e phahameng le libaka tsa moputso, batho ba nang le botsitso bo fokotsehileng ba ka ba le bothata ba ho feta liteko tse fanang ka moputso, tse lebisang menyetla e kholo ea ho ba batenya ho feta ba nang le boteng bo phahameng ba sebopeho.

Leha lithuto tsa pejana li sebelisitse DTI ho lekola likamano lipakeng tsa botenya le botšepehi ba litaba tse tšoeu (Kullmann, Schweizer, Veit, Fritsche, & Preissl, 2015 Kullmann, S., Schweizer, F., Veit, R., Fritsche, A., & Preissl, H. (2015). Bothata ba taba e tšoeu bo mabapi le botenya. Tlhahlobo ea botenya, 16 (4), 273-281. Doi: 10.1111 / obr.12248[CrossRef], [Lebokose], [Websaete ea Science ®]), thuto ena ke buka ea ho sebelisa mokhoa oa multimodal ho ts'oara sepheo sa pampitšana e ikhethileng ho laola litakatso tsa lijo. Phuputso ea morao-rao e bonts'itse hore IFG le OFC li kenya letsoho ho laola ts'ebeliso ea lijo bophelong ba letsatsi le letsatsi (Lopez et al., 2014 Lopez, RB, Hofmann, W., Wagner, DD, Kelley, WM, & Heatherton, TF (2014). Lits'oants'o tsa Neural tsa ho inehela molekong bophelong ba letsatsi le letsatsi. Setsebi sa Mahlale, 25 (7), 1337-1344. Doi: 10.1177 / 0956797614531492[CrossRef], [Lebokose], [Websaete ea Science ®]). Re sebelisa mokhoa ona oa fMRI, re pheta mantsoe a fetileng mme ra fumana hore IFG le OFC li bonts'itse ts'ebetso e matla ha batho ba jang lijo ba sa ts'oenyehe ba pepesehetse litabatabelo tsa lijo, re fana ka maikutlo a hore moputso le ts'ebetso e kholo ea taolo e ka sebetsa ka boithatelo nakong ea tlhahiso ea cue (Wagner et al., 2013 Wagner, DD, Altman, M., Boswell, RG, Kelley, WM, & Heatherton, TF (2013). Ho felloa ke taolo ho ntlafatsa likarabo tsa methapo ho meputso le ho sitisa taolo ea holimo holimo. Setsebi sa Mahlale, 24 (11), 2262-2271. Doi: 10.1177 / 0956797613492985[CrossRef], [Lebokose], [Websaete ea Science ®]). Mosebetsi oa lehae oa lijo tse hlahisang lijo tse fanang ka lijo o fana ka mokhoa o lebisitsoeng ho hlalosa libaka tsa IFG le OFC ho feta ho tiisa mask le ho etsa bonnete ba hore liphetho tsa "tractography" li thehiloe ho libaka tse sebetsang tse amanang le ts'ebetso ea cue ka har'a sampole e le 'ngoe. Mosebetsi ona oa fMRI oa lehae o ka thusa bafuputsi ho tseba ho fumana lipampitšana tsa litaba tse tšoeu tse amanang le taolo ea boits'oaro.

Ho ntse ho sa hlake hore na liphapang tsa batho ba taba e tšoeu li bakoa ke ho ja hangata. Leha boithuto bo fetileng bo fumane hore ho ikoetlisa khafetsa ho ka lebisa ho eketseha ha FA haholo lipampitšana tsa fiber (Scholz, Klein, Behrens, & Johansen-Berg, 2009 Scholz, J., Klein, MC, Behrens, TEJ, le Johansen-Berg, H. (2009). Koetliso e baka liphetoho moahong oa lintho tse tšoeu. Nature Neuroscience, 12 (11), 1370-1371. Doi: 10.1038 / nn.2412[CrossRef], [Lebokose], [Websaete ea Science ®]), hape ho ka etsahala hore ho hloleha ho ja ho fepa ho lebise ho botenya le lintho tse amanang le botenya, tse kang ho ruruha le dyslipidemia, tse ka bakang liphetoho lipuisanong tsa litaba tse tšoeu (Shimoji et al., 2013 Shimoji, K., Abe, O., Uka, T., Yasmin, H., Kamagata, K., Asahi, K.,… Aoki, S. (2013). Phetoho ea litaba tse tšoeu ho metabolic syndrome: Tlhahlobo ea tensor e fapaneng. Tlhokomelo ea lefu la tsoekere, 36(3), 696–700. doi:10.2337/dc12-0666[CrossRef], [Lebokose], [Websaete ea Science ®]). Boithuto ba nako e telele ea bokamoso boa hlokahala ho bona hore na phetoho ho boteng ba litaba tse tšoeu e bakoa ke ho ikoetlisa khafetsa lijong kapa linthong tse amanang le botenya. Boithuto ba nako e telele bo boetse bo hlokahala ho hlahloba kamano lipakeng tsa ho tšepahala hoa taba e tšoeu le liperesente tsa mafura a mmele ho lijong tse sa feleng. Leha ho hloa basali ba jang basali feela ho ka thibela phello e makatsang phapang ea bong, lithuto tsa nako e tlang li ntse li hlokahala ho bapisa hore na taba e tšoeu ea 'nete e na le tšusumetso liphetho tsa phepo lipakeng tsa banna le basali ba jang.

Qetellong, thuto ea hajoale e fana ka bopaki ba hore paki e tšoeu ea taba e amana le phapang e le 'ngoe ea liperesente tsa mafura a' mele lipampiteng tse hokahanyang libaka tse kenyelletsoeng morerong oa ho fokotsa lijo. Liphetho tsena li tsamaellana le mohlala oa ho itaola 'me li fana ka maikutlo a hore boteng ba litsela tse hokahanyang taolo e phahameng le libaka tsa moputso li ka bapala karolo ea bohlokoa ho fihlela katleho ea taolo ea nako e telele ho foleng.

Patlisiso e ncha e bonts'a katleho ea ho ja e kanna ea kenngoa kelellong

October 25, 2016