Neuropsychopharmacology. 2018 Feb;43(3):617-626. doi: 10.1038/npp.2017.215.
Feltmann K1, Giuliano C2, Everitt BJ2, Steensland P1, Alsiö J2,3.
inahaneloang
Bothata ba ho ja lijo-thollo (BED) bo khetholla likarolo tse ngata tsa ho sebelisoa ka tsela e feteletseng ea lijo tse natefisang le ho ba le kutloisiso e matla ea lijo. Bakuli ba nang le BED ba bonahatsa matšoao a ho lemalla lithethefatsi 'me tsamaiso ea dopamine e ka' na ea e-ba sepheo sa ho phekoloa. Monoamine stabilizer e sireletsehileng ea meriana (-) - OSU6162 (OSU6162) e tsosolosa ho se sebetse ha dopaminergic nakong ea nako e telele ea likhoho tse noang joala ebile e fana ka tšepiso ea hore ke phekolo ea morao-rao bakeng sa ho kula ha joala. Mona, liphello tsa OSU6162 ka ho fepa (ho ja lijo tse tloaelehileng) le mokhoa oa ho khotsofatsa (boitšoaro bo laoloang ke bolokolohi) bo susumelitsoeng ke li-pellets tsa chocolate-flavored pellets li ile tsa hlahlojoa lintlheng tsa banna tsa Lister Hooded tse se nang lijo. OSU6162 e fokolitse haholo ho fokotsa binge-joaloka tlhaho ea tsokolate-flavored sucrose pellets ntle le ho ama pele ho ts'epa. Ho feta moo, OSU6162 e ile ea fokotsa matla a ho batla likhetho tsa chocolate-flavored sucrose pellets tlas'a lenane la bobeli la ho matlafatsa pele, empa eseng ka morao, ho pepa le ho kenngoa ha moputso, e leng se bontšang ho khetha ho susumelletsa ts'ebetso ea ho susumetsa. Ka lehlakoreng le leng, raoprine ea dopamine D2 / D3 ea mohanyetsi oa li-raclopride e fokolitse ho batla chocolate-flavored sucrose pellets ka bobeli pele ho nako le moputso oa ho kenella le ho fokotsa ho arabela tlas'a lipampiri tse bonolo tsa ho batla boitšoaro. SCH1 ea nang le mohanyetsi oa D5 / 23390 o ne a se na phello ea boitšoaro ba lihlooho tlas'a lenaneo leha e le lefe la ho matlafatsa le neng le lekoa. Qetellong, tsamaiso ea OSU6162 ea lehae ka har'a nucleus accumbens mantlha, empa e se ka mokhoa o fokolang oa bolotsana, o khethollang sucrose e laoloang ka hloko. Qetellong, liphello tsa hona joale li bontša hore OSU6162 e fokotsa ho itšoara joaloka mokhoa oa ho ja le ho thibela liphello tsa ho batla lijo tse monate. Sena se bontša hore OSU6162 e ka sebetsa e le meriana ea BED ea morao-rao.
PMID: 28895569
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