Neuropharmacology. 2017 Jul 15; 121: 219-230. doi: 10.1016 / j.neuropharm.2017.04.040.
Blanco-Gandía MC1, Ledesma JC1, Aracil-Fernández A.2, Navarrete F2, Montagud-Romero S1, MA aguilar1, Manzanares J2, Miñarro J1, Rodríguez-Arias M3.
inahaneloang
Ho itlopa joala ho nkoa e le mofuta o itseng oa ho ja ho feta tekano o khetholloang ka ho ja lijo tse nang le likhalori tse ngata ka nako e khuts'oane. Lithuto tsa Epidemiologic li tšehetsa kamano e ntle lipakeng tsa ho kenella ha mafura le ethanol (EtOH), haholo-holo har'a lithuto tsa bocha. Morero oa mosebetsi ona e ne e le ho hlakisa karolo ea ho qobelloa ho ja lijo tse mafura haholo nakong ea bocha ka litlamorao tse ntle tsa EtOH. Kamora ho itlopa joala bakeng sa 2 h, matsatsi a mararo ka beke ho tloha ka letsatsi la pelehi (PND) 29, litlamorao tse matlafatsang tsa EtOH li ile tsa lekoa le EtOH self-administration (SA), maemo a khethiloeng a sebaka (CPP) le lits'ebetso tsa ts'ehetso ea ethanol locomotor ho motho e moholo e moholo litoeba. Liphoofolo tse sehlopha se phahameng sa ho itlopa joala (HFB) se ileng sa latela ts'ebetso ea EtOH SA se hlahisitse ts'ebeliso e kholo ea EtOH le tšusumetso e phahameng ea ho fumana sethethefatsi. Litoeba tsa HFB le tsona li hlahisitse khetho bakeng sa lekareche le kopaneng ho CPP le tekanyetso e nyane ea EtOH. Ka boikemelo ba lijo, litoeba li hlahisitse ts'oaetso ea "locomotor" e bakoang ke EtOH. Kamora ts'ebetso ea SA, litoeba tsa HFB li bonts'itse maemo a fokotsehileng a mu opioid receptor (MOr) le ho eketsa polelo ea liphatsa tsa lefutso ea li-cannabinoid 1 receptor (CB1r) ho li-nucleus accumbens (N Acc), le ho fokotseha ha polelo ea liphatsa tsa lefutso ea tyrosine hydroxylase (TH) ho ventral sebaka sa tegmental (VTA). Ha ho bokelloa liphetho ho fana ka maikutlo a hore ho itlopa joala ka mafura ho ka supa sesosa sa ho ba kotsing ea keketseho ea tšebeliso ea EtOH.
LINTLHA TSE LENG TSEO: Ho ja lijo tse ngata; Sebaka se khethiloeng ka sebaka; Ethanol; Letlalo; Puo ea Gene; Boikarabello ba boithati
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