Takatso ea lijo. 2017 Jan 20. pii: S0195-6663 (17) 30024-7. Doi: 10.1016 / j.appet.2017.01.004.
Pedram P1, Zhai G2, Gulliver W3, Zhang H4, Letsatsi la G5.
inahaneloang
Ho lemalla lijo (FA) ke karolo e ikhethang ea bongaka e amang batho ba baholo ba ka bang 5% sechabeng sa Canada. FA e kenya letsoho botebong, leha ho le joalo, liphatsa tsa lefutso tsa FA ha li tsejoe haholo. Morero oa boithuto ba hajoale e ne e le ho batla liphatsa tsa lefutso tsa mokhethoa oa FA ho sebelisoa tatellano ea chelete e lateloang ke boithuto ba netefatso ho sebelisoa liphatsa tsa lefutso tse amanang haholo. Ho tsoa ho batho ba baholo ba 752, ho ile ha khethoa lithuto tsa 24 ho kenyeletsoa batho ba 8 ba nang le boima bo phahameng le ba 8 ba nang le matšoao a tlase / zero FA ea matšoao a kliniki (FAO, NFO), le litsamaiso tse 8 tse phetseng hantle tse nang le BMI e tloaelehileng le lintlha tse tlase tsa zero (Ctrl) . Ho latellana ho hong ho phethetsoe lihlopheng tsohle tse tharo. Li-SNP tse 100 tse holimo li khethiloe li arotsoe ka lihlopha tse 5 tse ipapisitseng le liphatsa tsa lefutso: ho lemalla (Ad), mathata a kelello, matla a metabolism le botenya, le mofetše, ts'ebetso e sa tsejoeng kapa le mafu a mang. Thutong ea netefatso, li-SNP tse kaholimo ho 19 sehlopheng sa Lithethefatsi li ile tsa hlahisoa ka bongata lithutong tsohle tse 752 ho sebelisoa theknoloji ea Sequenom iPLEX Gold genotyping. Papiso ea NFO le Ctrl, le FAO le NFO, Ctrl le sehlopha se kopaneng sa NFO + Ctrl se senotse li-SNP tse 19 tse amanang le liphatsa tsa lefutso tsa Ad ho kenyelletsa, TIRAP, MMADHC, ERAP1, NTM, MYPN, GRID1, ITPR2, GPSM1, ZCCHC14, TNN, PPARD , CACNA1C, SIM1, le DRD2. Ho ile ha etsoa tlhahlobo ea mokhatlo oa liphatsa tsa lefutso. Allele e kholo A ea rs2511521 e fumanehang DRD2 (OR = 3.1 (95% CI 1.1-8.2)) le thelele e nyane T ea rs625413 e fumanehang TIRAP (OR = 2.5 (95% CI 1.1-5.8)) ho lithuto tsa NFO tse amanang haholo ka kotsi e eketsehileng ea ho lemalla lijo. Ho sebelisa mokhoa o kopaneng oa tatelano le mokhethoa oa lefapha la liphatsa tsa lefutso o atamela liphatsa tsa lefutso tse peli tse ncha tsa likhetho tsa FA. Ho ithuta ho eketsehileng ka liphatsa tsa lefutso tse mekhahlelong e meng e mene ho tla lumelloa.
LINKOTSO: Ts'ebetso ea setho sa setho sa botaki; Tatellano e ntle; Tlatsetso ea lijo; Liphatsa tsa lefutso
PMID: 28115213
DOI: 10.1016 / j.appet.2017.01.004
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