Ho lemalla Moferefere. 2015 Mar 29. Doi: 10.1111 / adb.12242.
Phetoho-Rodríguez O1, Albein-Urios N, Vilar-Lopez R, Perales JC, BOPHELO BA MOSEBETSI, Fernández-Serrano MJ, Lozano-Rojas O, Clark L, Verdejo-García A.
inahaneloang
Li-biomarkers tsa Neural bakeng sa litlamorao tse mpe tsa ts'ebeliso ea koae ea cocaine (CD) lia fokola. Papiso e tobileng ea khokahano ea boko ho marang-rang a lebisitsoeng ho cocaine lipakeng tsa CD le bokhoba ba boits'oaro (e leng tšibollo ea methapo ea kutlo, PG) e kanna ea ruta. Phuputso ena e ile ea bapisa likhokahano tsa khokahanyo ea tšebetsong tsa mmuso tsa batho ba 20 ba nang le CD, batho ba 19 ba nang le PG le batho ba 21 ba phetseng hantle (taolo). Lihlopha tsa boithuto li ile tsa hlahlojoa ho khaola litšebelisano tsa mafu a kelello (ntle le ts'ebeliso e mpe ea tahi le ts'ebeliso ea nicotine) le tšebeliso ea lithethefatsi kapa papali ea chelete hona joale (ntle le PG). Re qalile ka ho hlahloba phapano ea khokahano ea corticolimbic lefatšeng ka bophara, 'me ra sebelisa lipatlisiso tse thehiloeng ho peo ho supa tšebelisano ea libaka tse bonts'ang phapang lipakeng tsa sehlopha. Re hlahlobe likamano lipakeng tsa khokahano e thehiloeng hodima peo le ho ts'oaroa ke mekhoa le ho teba ha koae. CD ha e bapisoa le PG e bonts'itse ts'ebetso ea khokahano ea ts'ebetso ea lefats'e ka har'a marang-rang a maholo a marangrang a corticostriatal a kenyelletsang orbitofrontal cortex, caudate, thalamus le amygdala. Boithuto bo thehiloeng ho peo bo bonts'itse CD ha e bapisoa le PG e bonts'itseng khokahano lipakeng tsa orbitofrontal le subgenual cingulate cortices le lipakeng tsa caudate le lateral preortal preortal, tse amehang ho emela boleng ba karabelo ea ho etsa liqeto. CD le PG ha li bapisoa le lits'ebetso li bonts'itse liphetoho tsa khokahano e kopanyang pakeng tsa li-cortices tsa orbitof Pambali le dorsomedial pele le lipakeng tsa amygdala le insula, tse amehang ho ithuteng sephetho sa sephetho. Orbitofrontal-subgenual cingate cortical kgokahanyo e kopantsoeng le ho se tsamaee le ho kopantsha ha caudate / amygdala ho amana le ho teba ha koae ea koae. Re phethela ka hore CD e hokahane le khokahano e ntlafalitsoeng marang-rang a maholo a marang-rang a corticostriatal-amygdala a amanang le ho etsa liqeto mme mohlomong a bonts'a phello e mpe ea koae.
© Mokhatlo oa 2015 bakeng sa boithuto ba tlatsetso.
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