Mathata. 2013 May; 108 (5): 953-63. Doi: 10.1111 / eketsa.12066. Epub 2013 Jan 3.
Boileau I, Tefo D, Chugani B, Lobo D, Behzadi A, Rusjan PM, Houle S, Wilson AA, Warsh J, Kish SJ, Zack M.
mohloli o moholo
Sehlopha sa Lipatlisiso sa Keketso ea Tlatsetso, Setsi sa Tlatsetso le Bophelo ba Kelello, Toronto, ON, Canada. [imeile e sirelelitsoe]
inahaneloang
LITLHAHISO:
Pathological gambel (PG) e arolelana likarolo tsa ts'oaetso le bothata ba tšebeliso ea lithethefatsi (SUD), empa lits'ebetso tsa ts'ebetso ea methapo ea kutlo e sa utloisiseng hantle. Hobane dopamine (DA), neurotransmitter e kenyelletsang moputso le matlafatso, e kanna ea ameha, re sebelisitse positron emission tomography (PET) ho hlahloba hore na PG e amana le tlhekefetso ho maemo a D2 le D3 receptor, joalo ka ha ho hlokometsoe ho SUD.
Design:
Thuto-taolo ea thuto e bapisang PG le lithuto tse laolang bophelo bo botle (HC).
SETTING:
Setsi sa litšoantšo sa lipatlisiso tsa thuto.
KAROLO:
Banna ba leshome le metso e meraro ba sa batleng kalafo ba kopanang le litekanyetso tsa DSM-IV tsa PG, mme 12 e tšoana le HC (11 eo mang a qetile PET).
LIPHELO:
Liteko tse peli tsa PET (e 'ngoe e nang le D3 receptor e khethang agonist [11C] - (+) - propyl-hexahydro-naphtho-oxazin (PHNO) le e ngoe ka [11C] raclopride) ho hlahloba ho fumaneha ha li-D (2 / 3). le litloaelo tsa boits'oaro (lipotso tsa ho itlaleha le papali ea slot-Machine) ho hlahloba litlamorao le likamano lipakeng tsa mehato ea PET.
LITHUTO:
Ho tlama li-radiotracers ka bobeli ho ne ho sa tšoane lipakeng tsa lihlopha tsa striatum kapa substantia nigra (SN) (tsohle P> 0.1). Ho pholletsa le PG, [11C] - (+) - PHNO e tlamang SN, moo lets'oao le hlahisoang haholo-holo ke li-receptor tsa D3, tse amanang le matla a papali ea chelete (r = 0.57, P = 0.04) le ho potlaka (r = 0.65, P = 0.03) . Ho HC, [11C] raclopride e tlamang ho dorsal striatum e hokahaneng ka mokhoa o fapaneng le litlamorao tsa papali ea papali ea chelete.g (r = -0.70, P = 0.03) le impulsiveness (r = -0.70, P = 0.03).
CONCLUSIONS:
Ho fapana le bothata ba tšebeliso ea lithethefatsi, ho bonahala ho se na liphapang tse tšoailoeng maemong a D2 / D3 lipakeng tsa lithuto tse phetseng hantle le bathethehi ba methapo ea maoto, ho fana ka maikutlo a hore ho fumaneha ha "receptor" e tlase e kanna ea se be taba e hlokahalang. Leha ho le joalo, likamano lipakeng tsa [11C] - (+) - PHNO e tlamang le ho becha ho teba / ho se tsitse ho bonts'a ho kenya letsoho ha D3 receptor ka boits'oaro bo potlakisang / bo hatelletsang.
© 2012 Bangoli, Tlatsetso © 2012 Mokhatlo bakeng sa Thupelo ea Bokhoba.
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