Karolo ea ghrelin e bontšang boitšoaro ba thobalano ho litoeba tsa banna (2014)

Ghrelin, lets'oao la kelello ea ka mpeng, le tsebahala ho laola homeostasis ea matla, takatso ea lijo le takatso ea lijo ka pele ka li-receptors tsa hypothalamic ghrelin (GHS-R1A). Ntle le moo, ghrelin e kenya tšebetsong methapo ea moputso bokong, e leng sistamine ea mesolimbic dopamine, 'me e laola thepa e hlasimollang ea lithethefatsi tse tlatsetsang hammoho le lijo tse matlafatsang. Kaha re le mesolimbic dopamine sistimi e laela thepa e matlafatsang ea lithethefatsi tse tlatsetsang le meputso ea tlhaho, joalo ka boitšoaro ba thobalano, re nahana hore ghrelin e bapala karolo ea bohlokoa bakeng sa boitšoaro ba monna ba thobalano, e leng thuto bakeng sa lithuto tsa hona joale..

Mona re bontša hore kalafo ea ghrelin ea eketseha, athe khatello ea meriana (GHSR-1A antagonist JMV2959) kapa ho tlosoa hoa liphatsa tsa lefutso tsa GHS-R1A ho litoeba tsa banna ho fokotsa maikutlo a thobalano le boitšoaro ba thobalano le litoeba tsa basali ho oestrus. Phekolo ea pele le L-dopa (dopamine preursor) pele ho kalafo le JMV2959 e ile ea eketsa khetho ea mouse ea basali haholo ha e bapisoa le kalafo ea makoloi. Ho fapana le hoo, kalafo e nang le 5-hydroxythyptohan (selelekela sa serotonin) pele ho kalafo le JMV2959 e ile ea fokotsa tšusumetso ea thobalano ha e bapisoa le koloi. Litekong tse fapaneng, re bonts'a hore moea oa moea oa boea oa Grel le RHS-R1A ha li ame nako e sebelisitsoeng holim'a boroko ba basali joalo ka ha ho lekantsoe litekong tsa bethe tse itšetlehileng ka androgen. Ka kopanelo, lintlha tsena li bonts'a hore lihormin tse matla tsa tlala le se e amohelang li hlokahala bakeng sa boitšoaro bo tloaelehileng ba thobalano le litlamorao tsa mokhoa o supang ts'ebetso ea thobalano litabeng tsa thobalano li kenyelletsa dopamine neurotransmission.