Am J Psychiatry. 2001 Dec;158(12):2015-21.
Volkow ND, Chang L, Wang GJ, JS Fowler, Ding YS, Sedle M, Logan J, Franceschi D., Gatley J, Hitzemann R, Gifford A, Wong C, Pappas N.
mohloli o moholo
Lefapha la Bongaka, Brookhaven National Laborator, Upton, NY 11973, USA. [imeile e sirelelitsoe]
inahaneloang
MORERO:
Karolo ea dopamine ts'ebetsong ea bokhoba ba tahi (tahlehelo ea taolo le ts'ebeliso e matla ea lithethefatsi) ha e utloisisehe hantle. Ho fumana ho sa fetoheng lithutong tse lemalloang ke lithethefatsi ke boemo bo tlase ba li-receptor tsa dopamine D2. Ho batho ba hlekefetsang koae, lithethefatsi tse tlase tsa D2 li amahanngoa le boemo bo tlase ba metabolism ho cortex ea orbitofrontal. Hobane orbitof Pambal cortex e amahanngoa le boits'oaro bo qobelloang, ho senyeha ha eona ho ka kenya letsoho ho qobelloang ho kenella lithethefong lithutong tse lemaletseng. Phuputso ena e fuputse hore na mokhatlo o tšoanang o hlaha ho bafebi ba methamphetamine.
METHODO:
Bahlaseluoa ba leshome le metso e mehlano ba methamphetamine le lipapiso tse sa sebeliseng tlhekefetso e sa sebeliseng tlhekefetso ea lithethefatsi tsa 20 ba ithutile ka positron emission tomography (PET) le [11C] raclopride ho lekola ho fumaneha ha dopamine D2 receptors le [18F] fluorodeoxyglucose ea tlhahlobo ea "glucose" ea "metabolism" ea "metabolism". ts'ebetso ea boko.
LIKOTSO:
Basebelisi ba Methamphetamine ba ne ba e-na le boemo bo tlase haholo ba phumaneho ea li-D2 receptor ho feta lithuto tsa papiso (phapang ea 16% ho caudate le 10% ho putamen). Ho fumaneha ha li-receptor tsa D2 ho ne ho amana le tekanyo ea metabolic ho orbitofrontal cortex ho bahlaseli le lithutong tsa bapiso.
CONCLUSIONS:
Maemo a tlase a dopamine D2 phumaneho ea li-receptor e kile ea tlaleheloa ho ba hlekefetsang koae, lino tse tahang le ba hlekefetsang ba heroine. Boithuto bona bo atolosa ho fumana hona ho ba hlekefetsang methamphetamine. To hokahanya lipakeng tsa dopamine D2 receptors le metabolism ho cortex ea orbitofrontal ho bahlaseli ba methamphetamine, e phetang liphumano tse fetileng ho ba hlekefetsang cocaine, o fana ka maikutlo a hore D2 receptor-mediated dysregation ea orbitofrontal cortex e ka etsa mochine o tloaelehileng oa tahlehelo ea taolo le tšebeliso e mpe ea lithethefatsi. lithutong tse lemaletseng lithethefatsi.
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