Mosebetsi oa li-hypothalamic-pituitary-adrenal ho bakuli ba nang le papali ea chelete le bothata ba ho sebelisa marang-rang (2014)

Liphetoho tsa ho boloka lihormone tsa khatello ea kelello kahare ho axothalamic-pituitary-adrenal (HPA) axis li fumanoe khafetsa mathateng a amanang le lithethefatsi. Ho 'nile ha fanoa ka maikutlo a hore li-glucocorticoids li ka kenya letsoho ntlafatsong le tlhokomelong ea mathata a ts'ebeliso ea lithethefatsi ka litlamorao tsa likarabelo tsa boits'oaro linthong tsa tlhekefetso. Morero oa boithuto bona ba ho ba mofofisi e ne e le ho fuputsa ts'ebetso ea li-axis tsa HPA ho bakuli ba nang le mathata a amanang le lithethefatsi a sa amaneng le lithethefatsi, ke hore, papali ea chelete ea ho becha le ts'ebeliso ea inthanete.

Re ile ra lekanya maemo a plasma a copeptin, vasopressin surrogate marker, adrenocorticotropic hormone (ACTH) le cortisol ho bakuli ba batona ba nang le papali ea chelete ea ho becha (n = 14), ts'ebeliso ea ts'ebeliso ea inthanete (n = 11) le lits'oants'o tse nepahetseng tsa taolo ea papali ea chelete (n = 13) ) Le bothata ba ts'ebeliso ea inthanete (n = 10).

Tekanyo ea Plasma ea copeptin, ACTH le cortisol ho bakuli ba nang le bothata ba ho becha kapa ba ts'ebeliso ea inthanete ha ea ka ea fapana har'a lihlopha.

Leha ho le joalo, litekanyetso tsa "plasma" tsa "cortisol" li hokahane hampe le ho teba ha papali ea papali ea chelete joalo ka ha e lekantsoe ke PG-YBOCS. T

Hammoho le liphuputso tsa rona tsa li-serum tse eketsehileng tsa `` neurotrophic factor '' (BDNF) bokong bo amanang le papali ea chelete empa e se ts'ebeliso ea ts'ebeliso ea inthanete, liphetho tsena li fana ka maikutlo a hore pathophysiology ea papali ea chelete e arolelana likarolo tse ling le mathata a amanang le lithethefatsi a methapo ea kutlo, athe ho tšoana ho ne ho ke ke ha bonoa bothateng ba ts'ebeliso ea inthanete.