J Chromatogr B Mohlophisi oa Technol Biomed Life Sci. 2019 Mar 23; 1114-1115: 119-124. Doi: 10.1016 / j.jchromb.2019.03.027.
Lee CW1, Lee D2, Lee EM1, Park SJ1, Ji DY1, Lee DY3, Jung YC4.
inahaneloang
Mathata a Inthaneteng a Lipapali (IGD) a tšoauoa ka ho bapala ka mokhoa o sa laoleheng le o phehellang oa lipapali tsa inthanete leha ho bile le litlamorao tse mpe. Leha ho na le tlhoko ea kalafo ea lefats'e ka bophara, IGD e ntse e sena biomarker e hlakileng. Morero oa mantlha oa boithuto ke ho khetholla li-profil tsa lipidomic tse ikhethileng mabapi le bothata ba lipapali tsa inthanete (IGD) bo ipapisitse le mokelikeli oa chromatography Orbitrap mass-spectrometry (LC Orbitrap MS). Haholo-holo, lipids tsa 19 li ne li laoloa haholo ke sehlopha sa IGD ha se bapisoa le taolo e nepahetseng. Karolo ea lipidomic e ne e khetholloa haholo ke mefuta e fapaneng ea li-phosphatidylcholines (li-PC) le li-lyso-phosphatidylcholines (LysoPCs). Mefuta e latelang ea lipalo tsa multivariate le mofuta oa tatellano ea tatellano e ile ea beha liLysoPC tse peli pele (C16: 0 le C18: 0) bakeng sa biomarker e ka bang teng. Tlhahlobo ea sebapali se amohelang tšebetso (ROC) e bonts'itse ts'ebetso e ntle ea lipid e kopaneng bakeng sa ho khetholla sehlopha sa IGD ho tsoa taolong e phetseng hantle (AUC: 0.981, 95% karohano ea boits'epo: 0.958-1.000). Tlhatlhobo e tlatselletsang e ka bang le pherekano le likarolo tsa bongaka e fana ka maikutlo a ho ba matla le ho ka sebelisoa hoa sephetho joalo ka li-biomarker tse ka thusang ho hlahlojoa.
LINKOTSO: Bothata ba lipapali tsa inthanete (IGD); Lipidomics; Li-chromatography tse nang le metsi; Lyso-phosphatidylcholine; Orbitrap mass-spectrometry (LC-Orbitrap MS)
PMID: 30951964
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