LITLHAHISO: Sengoloa sena (bona thuto e ka tlase) se bua ka ho se leka-lekane ha dopamine. Ho se lekane ho ka ba liphatsa tsa lefutso kapa ho susumetsoa, kapa ka bobeli. Li nka mofuta oa phahameng kapa o tlase oa dopamine sensitivity (receptors), kapa maemo a phahameng kapa a tlase a dopamine. Phello e tloaelehileng ea bokhoba ba tahi ke ho ba le kutlo e tlase, leha ho le joalo e lokolla maemo a phahameng ho arabela litloaelo tsa bokhoba. Ke lumela hore ba lemaletseng ho kopanela liphate ba sehlopheng sena.
SEHLOOHO: (Reuters) - Tlhoko ea rona ea ho susumetsa le ho nka khato ea dopamine bokong e hokahane, e hlalosang hore na hobaneng batho ba lulang ba lakatsa ho hohela ba kotsing ea ho lemalla lintho tse kang ts'ebeliso e mpe ea lithethefatsi le papali ea chelete.
Takatso ea ho batla liphihlelo tse ncha ka mafolofolo ke tšobotsi eo bo-ramahlale ba kelello ba tsebileng ka eona ka lilemo, empa ho fihlela joale bo-rasaense ba ntse ba sa khone ho paka hore na takatso ena e amana joang le tšebetso ea lihormone bokong.
Batho ba nang le litekanyetso tse phahameng tsa "dopamine ea" hormone bokong, le kutloisiso e tlase ho eona, ba ipeha kotsing e kholo mme ba ka ba le tšekamelo ea ho lemalla ts'ebeliso e mpe ea lithethefatsi, tšebeliso e mpe ea lithethefatsi le papali ea chelete.
Bo-rasaense ba tsoang Denmark le Japane ba boletse hore ba pakile lipatlisisong hore tlhoko ea ho hlohlelletsa e kholo ka bongata ho ba nang le matla a ho khotsofatsa, "dopamine" bokong ba bona, karolo e 'ngoe e le hobane ba e rata hanyane.
Boithuto bo entsoeng ke Albert Gjedde oa Univesithi ea Copenhagen, mme bo phatlalalitsoe koranteng ea Pro Continings ea National Academy of Science (PNAS) ka Mantaha, bo ile ba hlahlobisisa kelello ea baithaopi ba phetseng hantle ho sheba maemo a dopamine le dopamine receptor.
"Batho ba pheletsong e phahameng ea sekala ba fumana phello e fokolang ho tsoa ho dopamine e lekanang le ea batho ba theohelang sekaleng, ho fihlela ba e-ba tlaase haholo ho dopamine hoo ho seng ho le tlase haholo ... ho ba le tšusumetso," Gjedde o bolelletse Reuters ka lengolo tsoibila .
Ba boletse hore liphumano li ka thusa bo-ramahlale ho theha mekhoa ea ho thibela kapa ho phekola bokhoba ba ho lematsa, ho re, le ho hlakisa mekhoa e mecha ea lithethefatsi maemong a kang tlhokomelo deficit hyperactivity disorder, eo hangata e bitsoang ADHD.
Bafuputsi ba re liphumano tsa bona li bonts'itse batho ba maemong a tlase le a phahameng ka ho fetisisa ba na le lintlha tse fapaneng haholo tsa dopamine le dopamine receptor, ba fana ka tlhahiso ea hore ho ka ba molemo ho leka ho eketsa kapa ho fokotsa maemo a dopamine ka boeona, ho fapana le ho thibela li-receptor.
Lithethefatsi tse kang Seroquel ea AstraZeneca le Eli Lilly's Zyprexa, tseo e leng tsa sehlopha sa lithethefatsi tse tsejoang e le li-antipsychotic, li sebetsa ka ho thibela ts'ebetso ea dopamine bokong.
Li amoheloa bakeng sa maloetse a kelello joalo ka khatello ea maikutlo, lefu la kelello le lefu la ho ferekana empa hape le ho ngolloa bana ba nang le ADHD.
SE ITHUTOANG: Kamano e harelaneng e nang le sebopeho se pakeng tsa dopamine receptor ho striatum le maikutlo a batlang
Albert Gjeddea, b, c, 1, Yoshitaka Kumakurab, d, Paul Cummingc, Jakob Linnetb, c, le Arne Møllerb, c
aDepartment of Neuroscience and Pharmacology, Yunivesithi ea Copenhagen, Copenhagen, Denmark 2200;
January 11, 2010
inahaneloang
Ho batla selling ke tšobotsi ea botho ea mantlha e fokotsehang ka lilemo ho banna le basali, joalo ka ho ba le letsoai le ho fumaneha hoa li-receptor tsa dopamine D2 / 3 libakeng tsa striatum le cortical. Ho fapana le hoo, ho batla bocha ka nako e itseng ho amana haholo le ho fumaneha ha dopamine receptor. Tlhaloso e bonolo ka ho fetisisa ea liphumano tsena ke khokahano e nang le sebopeho sa U-pakeng tsa litekanyetso tsa maikutlo ho batla sekhahla sa Zuckerman le dopamine D2 / 3 receptor. Ho lekola tseko ea kamano e nang le sebopeho se senngoeng-U pakeng tsa litekanyetso tsa botho bo batlang takatso ea maikutlo le mehato ea ho fumaneha ha dopamine, re sebelisitse PET ho rekota [11C] raclopride binding ho striatum ea banna ba phetseng hantle ba 18. Mona re tlaleha hore sebopeho se inverted-U se lekana haholo le ho fumaneha ha receptor e le ts'ebetso ea lintlha tsa Zuckerman, tse nang le bokhoni bo boholo ba ho tlama bo bonoang bohareng ba sekala. Sebopeho se kentsoeng-U se tsamaisana hantle le kamano e mpe lipakeng tsa ho ts'oasa maikutlo le ho boela re (mosebetsi) “phaello” ea dopaminergic neurotransmission ho dopamine. Ho ikamahanya le moo ho bonts'a lintlha tsa Zuckerman tse amanang le methapo ea methapo ea methapo ea methapo ho li-striatum empa e sa amaneng le dopamine. Ho lula ka holimo ho dopamine le ho tsepamisa maikutlo ho dopamine ho hlalosa tšusumetso e hohelang batho ba mahlomoleng ho batla maikutlo, tumellanong le ts'ireletso e fokotsehileng khahlano le boits'ebetso bo lemaletseng batho ba nang le bokhoni bo tlase.
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