Mathata a qobelloang a Matšoao a ho Qala-Tšusumetso (2006)

North Am. Sengoloa se ngotsoeng; e fumaneha ho PMC Mar 7, 2007.

E hatisitsoe ka mokhoa o qetelle o hlophisitsoeng e le:
PMCID: PMC1812126
NIHMSID: NIHMS13952
Jon E. Grant, JD, MD, MPHa,* 'me Marc N. Potenza, MD, PhDb
Moetso oa khatiso oa ho qetela oa mohatisi o fumaneha ho Psychiatr Clin North Am
Sheba lihlooho tse ling ho PMC hore Qotsa sehlooho se hatisitsoeng.

Case vignette

Anna, mosali ea nyetseng ea lilemo li 32, o itlhalositse e le "ea qobelloang." O tlaleha nalane, ho tloha ha a le moroetsana, ea bosholu ba ho se laolehe. O tlaleha hore nakong ea likhoeli tse 'maloa o ile a "tšoenyeha haholo" ka ho utsoa, ​​a nahana ka hona "letsatsi lohle." O tlaleha hore ho utsuoa ha hae ho qalile ha a ne a utsoa lipompong le metsoalle mme, ka nako e fetang likhoeli tse' maloa, a fetoha tloaelo e batlang e le ea letsatsi le letsatsi, eo a e entseng a le mong. Anna o tlaleha hore hajoale o utsoa ka makhetlo a mabeli ka beke. O tlaleha ho phahama kapa ho "potlakisa" nako le nako ha a utsoa. Ha e le hantle o utsoa lihlahisoa tsa bohloeki, joalo ka shampoo le sesepa. Hangata o utsoa mefuta e fapaneng ea ntho e le 'ngoe. Anna o tlaleha hore o na le mabokose a shampoo e le 'ngoe le sesepa tse patiloeng ka ntlong ea hae. O utsoa shampoo le sesepa tseo a sa li sebeliseng ebe o reka shampoo eo a e ratang le sesepa lebenkeleng le leng. Ha a botsoa hore na ke hobaneng ha a lahla shampoo, Anna o tlaleha hore ho ba le lihlahisoa tsena hoa "mo khothatsa." Ho utsoa mabenkeleng ha Anna ho ka qeta 2 ho lihora tsa 3 ka nako. Anna o boetse o hlalosa mehopolo ea letsatsi le letsatsi mme o khothaletsa ho ts'oara thepa e mo tšoenyang bakeng sa lihora tsa 3 ho isa ho lihora tsa 4 letsatsi le leng le le leng. A ka ba a tlohela mosebetsi kapele, ka diprojeke tse sa phethoang, e le hore a ka fihla lebenkeleng 'me a utsoe ntho e itseng. Ntle le moo, o thetsa monna oa hae, a mo joetsa hore o reka lintho tseo a li utsoitseng. Anna o tlaleha hore o "qobelletsoe" ho sesa thepa ea masholu.

Na Anna o na le bothata ba ho ba le khatello ea kelello kapa khatello ea kelello (OCD) kapa kleptomania? Na boitšoaro ba hae bo qobella, ha bo qobelle, kapa ka bobeli? Seo a se entseng se ka ama tšusumetso ea boitšoaro ba Anna joang? Na Anna a ka rua molemo ka ho fetisisa ho tsoa ka tekanyetso e phahameng ea serotonin reuptake inhibitor e khethiloeng, kapa na feto-fetoha kapa ho ba le maikutlo a feto-fetohang kapa naltrexone?

Ho susumetsa ho hlalositsoe e le mokhoa oa ho etsa qeto kapele, e sa reroang ho maikutlo a kahare kapa a kantle le ho sa natse litholoana tse babang [1]. Le ha mathata a itseng a thathamisitsoe ka tsela e le mathata a taolo ea ts'usumetso (ICDs), ho ts'oaroa ke karolo ea mantlha ea mathata a mangata a kelello (mohlala, mathata a ts'ebeliso ea lithethefatsi, lefu la ho ferekana kelellong, ho hloka taolo ea botho, ho se sebetse hantle ka lebaka la ho se sebetse hantle).

American Psychiatric Association e hlalosa ho qobelloa e le ts'ebetso ea boitšoaro bo pheta-pheo ka sepheo sa ho fokotsa kapa ho thibela ho tšoenyeha kapa khatello, eseng ho fana ka monyaka kapa ho khotsofatsa [2]. Le ha OCD e kanna ea ba pherekano e hlakileng ka ho fetisisa e nang le likarolo tse qobelloang, ho qobelloa hangata ke letšoao le hlahelletseng ho mafu a mangata a kelello (mohlala, mathata a ts'ebeliso ea lithethefatsi, mathata a botho, schizophrenia) [3].

Ba bang ba hlokometse hore lits'oants'o tsa ho susumetsoa le ho qobelloa ho hanyetsoa ka diametrically, empa kamano e bonahala e le thata le ho feta. Ho qobelloa le ho se ts'oanelehe ho ka hlaha ka nako e ts'oanang litsietsing tse ts'oanang kapa ka linako tse fapaneng hara mathata a ts'oanang, ka hona ho thatafatsa kutloisiso le kalafo ea boits'oaro bo itseng. Li-ICD, mathata a pele a khetholloang ka ho qobelloa, morao tjena a fumanoe a na le litšobotsi tsa ho qobelloa. Morero o ka sehloohong oa sengoliloeng sena ke ho hlahloba hore na ho qobelloa ho sebetsa joang ho li-ICD. Ts'ebetsong ena, sengoloa se boetse se hlahloba kamano pakeng tsa OCD le ICD.

Nalane, conceptualization e le 'ngoe ea li-ICD e bile karolo ea pono e bonoang e le matla [4]. Kutloisiso ea pele ea li-ICD e ne e ipapisitse le tlhaiso-leseling e teng mabapi le litšobotsi tsa bongaka tsa mathata ana, mekhoa ea phetisetso ea malapa, le likarabo kalafong ea meriana le ea kelello. Bukeng ea Diagnostic and Statistical Manual of Mental Disallen, khatiso ea bone, mongolo o ntlafalitsoeng (DSM-IV-TR), sehlopha sa li-ICD tse seng kae kapa kae moo ho boletsoeng hona joale se kenyeletsa ho phatloha ho hoholo ha sejoale-joale, kleptomania, pyromania, ho betla ha pathological (PG), le trichotillomania. Ho bile le mathata a mang bakeng sa ho kenyelletsoa ho ipapisitse le lintho tse ling tse nahanang hore ke tsa phenomenologic, tsa bongaka le tse ka 'nang tsa tšoana le tsa biologic: ho ferekanya kelello (ho thopa letlalo), ho reka ka mokhoa o qobelloang, tšebeliso e qobelloang ea inthanete le boitšoaro bo sa kopaneng ba ho kopanela likobo. Boemo boo li-ICD tsena li arolelanang likarolo tsa bongaka, liphatsa tsa lefutso, phenylogic le biologic bo utloisisoa hantle. Le ha li-ICD li ntse li sa pateloe, lipatlisiso mathateng ana li eketsehile haufinyane. Lintlha tse tsoang lithutong tsena li bontša kamano e rarahaneng lipakeng tsa li-ICD le OCD, heterogeneity ka har'a li-ICD, le karohano e rarahaneng pakeng tsa ho susumetsoa le ho qobelloa. Hobane lipatlisiso tse matla ho li-ICD tse ngata li na le moeli, sengoloa sena se bua haholo ka PG le trichotillomania, li-ICD tse peli tse fumaneng tlhokomelo e kholo ka ho fetisisa. E boetse e lekola kleptomania, eo, leha e sa ithute ho feta mafu a mang a kelello, e fumanang tlhokomelo e eketsehang ho tsoa ho baoki le bafuputsi. Sengoloa se sekaseka likamano lipakeng tsa li-ICD le OCD, likarolo tse qobelloang tsa li-ICD, le litlamorao tsa tleleniki bakeng sa ho lekola ho qobelloa ho li-ICD.

Papali ea papali ea chelete

PG, e tsebahalang ka mekhoa e sa khaotseng le e sa khaotseng ea boitšoaro ba papali ea chelete, e amahanngoa le ts'ebetso e sa sebetseng, bophelo bo fokotsehileng, le litheko tse phahameng tsa bosholu, tlhalo le ho kenella chankaneng [5]. Hangata PG e qala ha e sa le motho e moholo, 'me e tona e qala ho tloha bonyenyaneng [6]. Haeba e sa tloheloe e sa phekoloe, PG e bonahala e le boemo bo sa foleng, bo lulang bo ipheta.

Compulsivity e bolela boits'oaro bo phetetso bo etsoang ho latela melao e itseng kapa ka mokhoa o sistemeng, mme PG e amana le likarolo tse ngata tsa khatello. PG e tšoauoa ka boitšoaro bo pheta-pheto ba papali ea chelete le tšitiso e mpe ea boitšoaro. Batho ba nang le PG hangata ba hlalosa ho becha ho le thata ho e hanela kapa ho e laola, mme ka lebaka lena PG e bonahala e ts'oana le mekete e atisang ho hlaha, e sa hlokahaleng le e sa batleheng ea OCD. Ho feta moo, batho ba nang le PG hangata ba na le litloaelo tse ikhethileng tse amanang le ho becha ha bona (mohlala, ho roala liaparo tse itseng ha ho becha kapa ho becha ka metjhini e itseng ea slot). Khokahano e 'ngoe e kenyang lipakeng tsa PG le OCD ke boholo ba batho ba nang le PG ho etsa lintho tse ngata tse mpe tse ka' nang tsa baka tšenyo e kholo mesebetsing ea boipheliso kapa ea boits'oaro 'me ea baka tsitsipano ea motho [7]. Joalo ka OCD, boits'oaro bo qobelloang ba PG-papali ea papali ea chelete-hangata bo hlohlelletsoa ke boiphetetso kapa lintho tse u sithabetsang maikutlo [8]. Batho ba nang le PG hangata ba tlaleha hore litakatso tsa bona tsa ho becha li bakoa ke maikutlo a ho tšoenyeha, ho hlonama kapa ho jeoa ke bolutu [9,10].

Boithuto bo lula bo fumana hore batho ba nang le PG ba na le litheko tse phahameng tsa nako ea bophelo (60% –76%), matšoenyeho (16% –40%), le tse ling (23%) ICD [5,11,12]. Litekanyetso tsa ho hlaha pakeng tsa PG le OCD ha li lumellane haholo, leha ho le joalo. Mohlala, ka har'a disampole tsa lithuto tse nang le PG, litheko tsa li-OCD tse hlahang li tlohile ho 1% ho 20% [5], le ba bang, empa eseng kaofela, lithuto tse fumanang litheko tse phahameng tsa OCD (tse ka bang 2%) ho feta tse fumanoeng bongata ka kakaretso. Boithuto ba St. Louis Epidemiologic Catchment Area, leha ho le joalo, ha boa ka ba ba le kamano ea bohlokoa lipakeng tsa papali ea chelete le OCD (karo-karolelano ea 0.6 bakeng sa OCD mathateng a papali ea chelete ha e bapisoa le bao e seng ba papali ea chelete).13]. Leha thuto ena e ile ea bokella datha ho li-1980, ke eona feela thuto e phatlalalitsoeng ho tla fihlela kajeno moo ho ileng ha hlahlojoa sampole ea sechaba bakeng sa tlhahlobo ea DSM bakeng sa li-OCD le PG.

Boithuto ba PG har'a batho ba nang le OCD bo tlalehile hanyane, haeba ho na le kamano e teng lipakeng tsa PG le OCD. Leha lithuto tsa sampole tse nyane tsa OCD li tlalehile litheko tsa PG ho tloha 2.2% ho isa 2.6% [14,15], boithuto bo sa tsoa qeta ba sampole e kholo ea lithuto tse neng li na le OCD ea mantlha (n = 293) e fumane litekanyetso tsa hona joale (0.3%) le nako ea bophelo (1.0%) PG [16] tse neng li se kholo ho feta ho bongata ka kakaretso (0.7-1.6%) [13]. Liphumano tsena tsa morao-rao li lumellana le tse tsoang sampoleng ea batho ba fetang 2000 ba neng ba e-na le OCD moo litekanyetso tsa hona joale le tsa nakong e fetileng tsa PG li neng li le tlase ho 1% [17]. Ka mokhoa o tšoanang, thuto ea lelapa ea li-probands tsa OCD ha ea ka ea fumana bopaki ba kamano e bohlokoa pakeng tsa OCD le PG kapa OCD le ICDs ka kakaretso (ntle le mathata a ho itšireletsa le ho ja) [18].

Lithuto tsa nalane ea lelapa tsa lithuto tse nang le PG li na le meeli. Batho ba batšo le basebetsi-'moho [19] e hlahlobile lithuto tsa 17 tse neng li na le PG le 75 tsa beng ka tsona tsa pele. Phuputso e fumane hore 1% ea baena ba pele-pele e na le OCD (e tšoanang le litefiso sechabeng), ha e bapisoa le e mong sehlopheng sa taolo. Le ha mohlala o ne o le monyane, thuto e sebelisitse sehlopha sa taolo hammoho le lipuisano tse hlophisitsoeng bakeng sa lithuto le beng ka sehlopha sa pele. Joalo ka thutong ea li-probands tsa OCD, thuto ea lelapa ea lithuto tse neng li na le PG le beng ka tsona li ile tsa hloleha ho fumana khokahano lipakeng tsa PG le OCD.

Leha bokantle ba PG bo arolelana likarolo tse ngata tsa mohopolo le OCD, boholo ba data bo fana ka maikutlo a hore ho ba teng lipakeng tsa mathata ana ha ho phahamisoe. Ka hona ho bonahala eka PG e na le likarolo tse ngata tse qobelloang empa ha e amanang le litheko tse phahameng tsa OCD. Lebaka le leng la ho bona sena le ka kenyelletsa lithibelo tsa tlhahlobo ea lihlahisoa. Tlhaloso e 'ngoe, eseng e fapaneng ka bobeli ke hore leha likarolo tse qobelloang li bonoa mofuteng o mong le o mong, likokoana-hloko tsa lisosa li fapana. Taba e 'ngoe ke hore likarolo tsa ho qobelloa li ka fapana lipakeng tsa mafu.

Ho lekola ho qobelloa ho OCD le ho PG le li-ICD tse ling ho ka hlakisa karolo ea ho qobelloa moferekong o mong le o mong. Leha lithuto tse ngata li lekotse ho ts'oaroa le ho amanang ho amanang le (mohlala, ho batla maikutlo) ho PG [5,20], ba fokolang ba fumaneng tlhahlobo ea ts'usumetso ho PG. Phuputsong e 'ngoe (Padua Inventory), batsomi ba methapo ea methapo ea methapo ba ile ba ipeha maemong a holimo ho feta taolo e tloaelehileng ka tekanyo e itseng ea ho qobelloa [21]. Phuputso ea morao-rao e lekang ho utloisisa likarolo tse qobelloang le tse sa susumetseng tsa PG e sebelisitse Padua Inventory ho hlahloba lithuto tsa 38 pele le kamora libeke tsa 12 tsa kalafo ka paroxetine [22]. Patua Inventory e lekanya ho tsoa le ho qobelloa mme e na le lintlha tse 'ne [23]:

  1. Taolo e sa laoleheng ea mesebetsi ea kelello, e lekolang rumours le lipelaelo tse feteletseng
  2. Boiketsi ba ho silafatsa
  3. E ea hlahloba
  4. Taolo e sa senyeheng ea ts'ebetso ea makoloi e lekanyang litlhoko le matšoenyeho a amanang le boits'oaro ba makoloi, joalo ka litšusumetso tse mabifi

Motheong, matšoao a ho teba ha pf PG a ne a amahanngoa le likarolo tsa ho ts'oaroa le ho qobelloa (haholo-holo lintlha tsa 1 le 4 tsa Padua Inventory). Nakong ea kalafo, lintlha tse felletseng mabapi le mehato ea ho susumetsoa le ho qobelloa li fokotsehile, ka ho fokotseha ho hoholo ho bonoang ho factor 1 ea Padua Inventory le subscalesness subscales tsa Eysenck Impulsivity Questionnaire [22]. Boithuto bona bo fana ka maikutlo a hore ho qobelloa le ho se qobelloe ho PG li sebetsa ka tsela e rarahaneng, le hore mehato ea ho potlaka le ho qobelloa e amana le sephetho sa kalafo. Ho felletseng hoa sepheo sena ke hore ho qobelloa kapa ho qobelloa (kapa likarolo tse ikhethang tsa e 'ngoe le e' ngoe) ho ka emela lipheo tsa kalafo bakeng sa PG.

Le ha pathogenesis e le sesupo se hlakileng sa hore na mathata a amanang le kamano, ke palo e fokolang feela ea lipatlisiso e entseng lipatlisiso tsa li-neurobiologic tsa PG, mme bopaki bo fana ka tlhahlobo e fapaneng ea thuto ea mafu ho tsoa ho se boneng ho OCD. Phuputso e sebetsang ea MRI ea papali ea papali ea papali ea papali ea chelete ea banna ho becha e fana ka maikutlo a hore PG e na le likarolo tsa neural (tse fokotsang ts'ebetso kahare ho dikarolo tsa cortical, basal ganglionic, le thalamic brain ka lithuto tse nang le PG ha li bapisoa le taolo) e fapaneng le semelo sa ts'ebetso ea boko se bonoang ho cue Lithuto tsa morao-rao tsa OCD (mosebetsi o eketsehileng oa cortico-basal-ganglionic-thalamic) [24,25]. Le ha lipatlisiso mabapi le neurobiology ea PG li ntse li eketseha, kamano ea neurobiologic ea PG ho OCD e ntse e lokela ho tšoaneleha. Ho hlokahala lithuto tse hlophisehileng haholoanyane tsa PG le OCD (mohlala, tse bapisang ka kotloloho le ho bapisa lithuto tse sebelisang "paradigm" e tšoanang).

Phekolo ea ho becha ha methapo ea methapo

Qalong ho ne ho fanoa ka maikutlo a hore PG, joalo ka OCD, e ka bonts'a karabelo e khethiloeng ho serotonin reuptake inhibitors (SRIs). Lintlha tse tsoang litekong tse foufalitsoeng ke li-pharmacotherapy tse foufalitsoeng habeli kalafong ea PG, ha li anngoe, leha ho le joalo [7], ka moriana o bonts'a monyetla o motle ho feta placebo ho a mang empa eseng litekong tse ling tsa li-SRIs [26-29]. Ntle le moo, PG e bontšitse likarabo ho bahanyetsi ba opioid [30,31], lithethefatsi tse sa kang tsa bontšoa li sebetsa hantle kalafo ea OCD. Karabelo ea PG ho kalafo ea pharmacologic e ithutoe ka mokhoa o sa lekanang ho tseba ka ho hlaka khetho ea kalafo. Hore na mehato ea ho qobelloa e ka sebelisoa hakae ho tsamaisana le kalafo e ikhethileng le batho ba itseng ba nang le PG kapa ba sebelisitsoeng ho hlahloba kapa ho bolela sephetho sa kalafo ho sa ntse ho lokela ho hlahlojoa.

Phekolo ea kelello le ea boitšoaro tse sebetsanang le karolo e qobelloang ea PG li bontsitse molemo oa pele [32]. Phekolo ea boits'oaro ba kelello bakeng sa PG, leha ho le joalo, e fapana le kalafo ea ho pepeseha le karabelo e sebelisetsoang OCD [33]. Phekolo ea kelello e shebana le ho fetola tumelo ea mokuli mabapi le taolo e nahanoang mabapi le liketsahalo tse ikemiselitseng ka boomo. Phekolo ea kelello e thusa mokuli ho utloisisa hore melao ea monyetla, eseng boitšoaro ba tloaelo, e laola sephetho sa papali ea chelete. Phuputsong e 'ngoe, kalafo ea motho ka mong e bakileng ho fokotseha khafetsa ha papali ea papali ea chelete le ho eketsa taolo ea papali ea papali ea chelete ha e bapisoa le taolo ea lenane la ho leta [34]. Phuputso ea bobeli e neng e kenyelletsa thibelo ea ho khutlela morao e boetse e hlahisitse ntlafatso matšoao a papali ea papali ea chelete ha e bapisoa le taolo ea lenane la ho leta [35].

Phekolo ea boitšoaro bo botle ba kelello le eona e sebelisitsoe ho phekola PG. Karolo ea boits'oaro e sebetsana le mekhoa e meng e ka sebelisoang bakeng sa ho becha. Teko e le 'ngoe e khethiloeng e ile ea bapisa mefuta e mene ea kalafo: (1) taolo ea tšusumetso ea motho ka mong le ho pepeseha ha vivo le thibelo ea karabelo, (2) tlhahlobo ea kelello ea sehlopha, (3) motsoako oa mekhoa 1 le 2, le (4) taolo ea lenane la ho leta . Likhoeling tsa 12, litekanyetso tsa ho thibeloa kapa ho becha hanyane li ne li le holimo ho phekolo ea motho ka mong (69%) ho feta sehlopheng sa ntlafatso ea kelello (38%) le lihlopha tse kopaneng tsa kalafo (38%) [36]. Teko e ikemetseng, e laoloang, e thehiloeng holim'a litlhare tse sebelisoang ho phekola mafu a sebelisang lithethefatsi le ho kenyelletsa maano a thibelo ea ho oela hape, e ntse e tsoela pele; Liphetho tsa mantlha li bonts'a katleho ea kalafo e tsamaeang le tlhalohanyo ea monna [37].

Phuputso e 'ngoe ea ho kenella hanyane ka sebopeho sa buka ea mosebetsi (e neng e kenyelletsa mekhoa ea ntlafatso ea kelello le mekhoa ea ho khothaletsa) e bapisoa le ts'ebeliso ea buka ea mosebetsi hammoho le tlhahlobo e le' ngoe ea mooki [38]. Lihlopha tsena ka bobeli li tlaetse phokotso ea bohlokoa papaling ea chelete ea 6 kamora khoeli. Ka mokhoa o ts'oanang, thuto e arohaneng e abetse basomi ho sebelisa buka ea mosebetsi, ho sebelisa buka ea ho sebetsa le molaetsa o ntlafatsang oa mohala, kapa lenane la ba emetse. Ha ho bapisoa le ba sebelisang buka ea mosebetsi o le mong, ba bechang ba abeloang ts'ebetso ea ts'ebetso ea khothaletso hammoho le buka ea mosebetsi ba fokotsitse papali ea chelete nakong eohle ea ho latela ea 2 [39].

Liphuputso tse peli li boetse li lekile kalafo ea ho hlapanya le takatso ea ho nahana ka merero e sa sebetseng. Phuputsong ea pele, kalafo ka bobeli li hlahisitse ntlafalo mohlaleng o fokolang oa bakuli [40]. Thutong ea bobeli, libapali tsa 120 tsa li-geologic li ile tsa abeloa ka mokhoa o sa lekanyetsoang kalafo ea ho tlohela, ho nahana ka takatso, boikemisetso ba vivo, kapa boikhathollo ba monahano. Barupeluoa ba fumanang takatso ea monahano ba hlalositse litholoana tse ntle ho 1 khoeli le ho fihlela lilemo tsa 9 hamorao [41].

Trichotillomania

Trichotillomania e hlalositsoe e le ho pheta-pheta, ho kuta moriri ka boomo ho bakang tahlehelo ea moriri mme ho fella ka khatello ea maikutlo kapa ho fokola hoa tšebetso [2]. Ho tšohloa kae kapa kae makasineng ena, trichotillomania e bonahala e tloaelehile haholo, 'me ho na le khakanyo e teng pakeng tsa 1% le 3% [42]. Lilemo tse boleloang qalong ea trichotillomania ke lilemo tse ka bang 13 [43].

Mokhoa o pheta-phetoang oa boea ba ho hula moriri ka mokhoa oo ho nahanoang hore o fokotsehile o tšoana le OCD ka tsela e makatsang. Ho fapana le OCD, moo ho qobelloang ho etsahalang maemong a fapaneng, batho ba nang le trichotillomania ba atisa ho hula khafetsa ha ba etsa mesebetsi ea ho lula fatše [44]. Le ha ho hula moriri ho trichotillomania ho fokotsa ho tšoenyeha, joalo ka ha ho etsoa ka litlatsetso ho OCD, ho kanna ha hlahisa maikutlo a thabo, athe hangata litletlebo tsa OCD ha li etse joalo.

Trichotillomania ka nepo e 'nile ea nkuoa e le ts'oaetso e amang basali hangata [45] khafetsa e amahanngoa le khatello ea maikutlo (39% –65%), bokuli ba ho tšoenyeha ka kakaretso (27% –32%), le tlhekefetso ea lithethefatsi (15% –20%). Haholo-holo, litheko tsa li-OCD tse hlahang li kopane haholo (13% –27%) [43] ho feta e fumanoeng sechabeng (1% –3%) [46], mme comorbidity ena e phahamisa monyetla oa tsela e ka tlase e tloaelehileng ea neurobiologic bakeng sa mamello e bonoang litsietsing tsena tse peli. Trichotillomania ha e kopantsoe le litheko tse phahameng tsa matšoao a bonts'a matla, a na le lintlha tse ngata ka har'a mofuta o tloaelehileng [44].

Litefiso tsa trichotillomania har'a batho ba nang le OCD ha li lumellane lithutong tsohle. Lithuto tse tharo tsa disampole tse nyane tsa lithuto tsa OCD li tlalehile litekanyetso ho tloha 4.6% ho 7.1% [14,15,47]. Phuputso e le 'ngoe e kholo ea lithuto tsa 293 tse nang le OCD li tlalehile nako ea bophelo le litekanyetso tsa hona joale tsa trichotillomania ea 1.4% le 1.0%, ka ho latellana [16]. Joalo ka PG, potso e ntse e le hore na ho lekola sebaka sa ho qobelloa ho pholletsa le mathata ana ho ka fana ka leseli mabapi le monyetla oa pathophysiology.

Kamano e pakeng tsa trichotillomania le OCD e ts'ehetsoa ho fumanoang hore OCD e tloaelehile ho baena ba lithuto tse nang le trichotillomania. Leha lithuto tsa nalane ea lelapa tsa trichotillomania li fokola, thuto e le 'ngoe e khothalelitse kamano ea lelapa le OCD. Boithuto bona bo ne bo kenyelletsa lithuto tsa 22 tse neng li e-na le li-trichotillomania le beng ba 102 ba pele. Ha ho bapisoa le sehlopha sa taolo (n = 33, le baena ba "182-degree" ea pele, haholo-holo ba amanang le "trichotillomania probands") ba ne ba na le OCD (2.9%) ha ba bapisoa le sehlopha sa taolo [48]. Boithuto ba lelapa ba li-OCD probands bo fumane karolo e phahameng ea lithuto tsa linyeoe ho feta lithuto tse laoloang li ne li le trichotillomania (4% bapisoa le 1%), leha phapang e ne e se ea bohlokoa ka lipalo ho latela boholo ba sampole [18].

Phekolo ea trichotillomania

Mekhoa ea kalafo e hlahlojoang bakeng sa trichotillomania e kenyelletsa ho kenella hoa litlhare le boits'oaro. Ho thehiloe hantle hore kalafo ea mantlha ea pharmacologic bakeng sa OCD ke SRI (mohlala, clomipramine, fluvoxamine, kapa fluoxetine). Lintlha tse mabapi le matla a li-SRIs bakeng sa trichotillomania ha li kholise, leha ho le joalo. Phuputso e le 'ngoe e ile ea bapisa clomipramine le desipramine ho libeke tsa 10 tse se nang mahlo a mabeli, tse nang le sebopeho (libeke tsa 5 bakeng sa moemeli ka mong kamora libeke tsa 2 tsa lead-in single-blind)49]. Lithuto tse leshome le metso e 'meli tsa 13 li bile le ntlafatso ea bohlokoa ha li fumana Clomipramine. Le ha li-SRI li sebetsa hantle bakeng sa OCD, meriana ena e bontšitse litholoana tse tsoakaneng litekong tse tharo tse sa reroang tsa trichotillomania [50-52]. Ntle le moo, batho ba nang le trichotillomania le ba phekotsoeng ka katleho le SRI ba atisa ho ba le matšoao a phahameng ho feta a batho ba tšoaroang ke SRI ba nang le OCD [51].

Litsi tse ling tsa pharmacologic tse bonts'itseng molemo bakeng sa trichotillomania ha li sebetse bakeng sa OCD. Ho haelloa ke katleho ena ho hlahisa lipotso ka phapang e teng lipakeng tsa mafu ana. Christenson le basebetsi-'moho [51] bapisa le opioid antagonist naltrexone le placebo ho beke ea 6 ea beke le beke, e nang le mahlo a mabeli le e tšoanang. Ntlafatso ea bohlokoa e ile ea bonoa bakeng sa sehlopha sa naltrexone ka tekanyo e le 'ngoe ea matšoao a trichotillomania. Phuputsong e ngotsoeng e bulehileng ea lithium, 8 ea lithuto tsa 10 e tlalehiloe e fokotseha ho hula khafetsa, palo ea moriri o huloang, le boholo ba tahlehelo ea moriri [53] Hangata Lithium e bile molemo ho phekoleng batho ba nang le mathata a tšoaetso a nang le tšusumetso e mpe ea tšusumetso [54]. Liphetho tse ntle tse tsoang litekong tsa label tse bulehileng.53] phahamisa monyetla oa hore litšusumetso tse matla ntle le ho li qobella li emela sepheo sa kalafo sa bohlokoa ho batho ba bang ba trichotillomania. Teko e tobileng ea hypothesis ena ea hlokahala pele kopo ena e ka netefatsoa.

Ka bobeli OCD le trichotillomania li arabela ho kenella ha boits'oaro; leha ho le joalo, mekhoa ea phekolo ea boitšoaro e fapana haholo. Azrin le basebetsi-'moho [55] A file li-34 ka mokhoa o sa reroang kalafo ea ho fetola mekhoa ea boikoetliso kapa litloaelo tse mpe (tseo ho tsona lithuto li neng li laetsoe ho ema ka pel'a seiponeng ebe li etsa menyako ea ho hula moriri ntle le ho hula). Habit reversal e fokotsitse ho hula moriri ka ho feta 90% bakeng sa likhoeli tsa 4, ha ho bapisoa le 52% ho fokotsa 68% bakeng sa tloaelo e mpe likhoeling tsa 3. Ha ho sehlopha sa taolo se kenyellelitsoeng, ka hona nako le tlhokomelo ea litsebi li ne li sa khone ho hlahlojoa.

Phuputso ea morao-rao e hlahlobile lithuto tsa 25 ka mokhoa o ikhethileng ho libeke tsa 12 (likarolo tsa 10) tsa ho amohela le ho itlhahisa kalafo / ho feto-fetoha ha tloaelo kapa lenane la ho leta [56]. Lintlha tse abetsoeng kalafo li bile le phokotso e kholo litlamorao tse tebileng tsa ho kuta moriri le ho senyeha ha li bapisoa le tse abetsoeng lenane la ho leta, 'me ntlafatso e bolokiloe kamora ho latela khoeli ea 3.

Kleptomania

Likarolo tsa mantlha tsa kleptomania li kenyelletsa (1) ho hloleha khafetsa ho hanela tšusumetso ea ho utsoa lintho tse sa lomosoang; (2) mohopolo o ntseng o eketseha oa tsitsipano pele o utsoa; (3) boiphihlelo ba menyaka, khotsofalo, kapa tokollo ka nako ea ho utsoa; le (4) ho utsoa ho sa etsoe ka lebaka la khalefo, phetetso, kapa hobane ho na le psychosis [2].

Joalo ka OCD, hangata kleptomania e qala ho hlaha nakong ea bohlankana kapa boroetsaneng.57]. Hangata, thupelo e lula e sa fole ka ho holofala le ho tsofala ha matšoao. Ho fapana le OCD, basali bona ba na le menyetla e imenneng habeli ho feta ea banna ea ho tšoaroa ke kleptomania [57]. Phuputsong e le 'ngoe, bohle ba neng ba nkile karolo ba tlaleha litlhoko tse eketsehileng tsa ho utsoa ha ba leka ho khaotsa ho utsoa [57]. Bokhoni bo fokotsehileng ba ho emisa khafetsa bo lebisa ho maikutlo a lihlong le letsoalo le molato, tse tlalehiloeng ke lithuto tse ngata (77.3%) [57].

Le ha batho ba nang le kleptomania ba lula ba utsoa lintho tse fapaneng libakeng tse ngata, boholo ba bona bo utsoa mabenkeleng. Phuputsong e le 'ngoe, 68.2% ea bakuli ba tlalehile hore boleng ba lintho tse utsoitsoeng bo eketsehile ha nako e ntse e feta [57]. Bongata (64% -87%) ba ts'oeroe ka nako e itseng ka lebaka la boits'oaro ba bona [58], le 15% ho 23% e tlaleha hore ba ahlotsoe chankaneng [57]. Le ha boholo ba bakuli ba ts'oeroeng ba tlalehile hore litakatso tsa bona tsa ho utsuoa li fokotsehile kamora ho ts'oenyeha, ho hlakoloa ha matšoao ho bile feela ka matsatsi kapa libeke tse 'maloa.58]. Ka bobeli, liphumano tsena li bonts'a ho ikamahanya leseling boits'oarong bo bobebe leha ho bile le litlamorao tse mpe.

Boitšoaro bona bo pheta-phetoang bo bonoang kleptomania bo fana ka maikutlo a ho qobelloa, joalo ka vignette e bulang sengoloa sena. Ntle le moo, batho ba bangata ba nang le kleptomania (63%) ba boloka lintho tse khethehileng tseo ba li utsoitseng [57]. Diteko tsa botho tsa batho ba nang le kleptomania li bontša, leha ho le joalo, hore ka kakaretso ba batla maikutlo [59] le tse qobelloang [60] ka hona re fapane le batho ba nang le OCD, bao ka tloaelo ba leng thibelo e kotsi ka tšusumetso e mpe ea ho qoba boits'oaro ba bona [4]. Ho fapana le batho ba nang le OCD, batho ba nang le kleptomania ba ka tlaleha tšusumetso kapa takatso e itseng pele ba kenya letsoho ho utsoa le boleng ba hedonic nakong ea ts'ebetso ea bosholu [7].

Sekhahla se phahameng sa mathata a mang a kelello se fumanoe ho bakuli ba nang le kleptomania. Litekanyetso tsa bophelo ba mathata a amanang le comorbid a tloha ho 59% [61] ho 100% [58]. Boithuto bo boetse bo fumane litheolelo tse phahameng tsa bophelo ba mathata a matšoenyeho a comorbid (60% ho 80%) [58,62] le mathata a tšebeliso ea lithethefatsi (23% ho 50%) [58,61].

Hore na OCD le kleptomania li sebetsa hammoho ha ho utloisisehe hantle. Litekanyetso tsa li-OCD tse hlahang ka har'a sampole ea batho ba nang le kleptomania li tloha 6.5% [61] ho 60% [63]. Ka lehlakoreng le leng, litekanyetso tsa kleptomania ka har'a disampole tsa OCD li bonts'a tekanyo e phahameng ea liketsahalo tse kopaneng ho feta e fumanoang sechabeng (2.2% –5.9%) [14,15]. Phuputso ea morao-rao ea lihlooho tsa 293 tse neng li na le OCD li tlalehile litekanyetso tsa hona joale le tsa bophelo ba kleptomania (0.3% le 1.0%) [16] tse neng li le tlase ho litheko tse fumanoeng ho palo ea batho ba nang le mafu a kelello (7.8% le 9.3%, ka ho latellana) [64]. Boithuto bo boholo ba mafu a kelello a lefu la kelello a kenyelletse mehato ea kleptomania, ka hona a fokotsa tsebo e fumanehang mabapi le ho ata ha eona le mekhoa ea ho hlaha le mathata a mang a kelello.

Phuputso ea nalane ea lelapa e bapisitse batho ba 31 ba neng ba e-na le kleptomania le 152 ea beng ka bona ba pele ba nang le lithuto tsa taolo ea 35 le 118 ea beng ka bona ba pele [61]. Phuputso e fumane hore 0.7% ea baena ba kleptomania proband ba ne ba le mahlomoleng a OCD bapisoa le 0% malapeng a batsamaisi.

Phekolo ea kleptomania

Ke feela litlaleho tsa linyeoe, letoto la linyeoe tse peli tse nyane, le boithuto bo le bong bo bulehileng ba pharmacotherapy li entsoe kleptomania. Ho fumanoe meriana e mengata litlalehong tsa linyeoe kapa letoto la linyeoe, 'me tse' maloa li fumanoe li sebetsa: fluoxetine, nortriptyline, trazodone, clonazepam, valproate, lithium, fluvoxamine, paroxetine, le topiramate [65]. Ho fapana le kalafo ea OCD, ha ho bonahale eka ho na le karabelo e ikhethang ea kleptomania ho meriana ea serotonergic. Teko e le 'ngoe feela e hlophisitsoeng ea meriana bakeng sa kleptomania e kenyelletsa lithuto tsa 10 ho beke ea 12-beke, tlhahlobo e bulehileng ea naltrexone. Ka tekanyo e kholo ea 150 mg / d, meriana e hlahisitse ho fokotseha ho hoholo hoa takatso ea ho utsoa, ​​mehopolo ka ho utsoa, ​​le boitšoaro ba ho utsoa [66].

Leha mefuta e mengata ea maikutlo a kelello e hlalositsoe kalafong ea kleptomania, ha ho liteko tse laoloang tse teng ka har'a lingoliloeng. Mefuta ea psychotherapy e hlalositsoeng litlalehong tsa linyeoe e le ho bonts'a katleho e kenyelletsa ts'ebetso ea kelello le kelello, le mahlale a boits'oaro [58,67]. Hobane ha ho liteko tse laoloang tsa kalafo bakeng sa kleptomania tse phatlalalitsoeng, ho thata ho lekola mesebetsi e kenelletseng, empa maemo a phallo ea kelello, joalo ka meriana, a fana ka maikutlo a hore kleptomania e matla.

Summary

Joalokaha ho bonoa vignette ea kenyelletso, li-ICD li tšoauoa ka boitšoaro bo pheta-phetoang le bo sitisang boitšoaro bona. Litloaelo tse thata tsa taolo ea li-ICD li fana ka maikutlo a tšoanang le litloaelo tsa OCD tse atisang ho hlaha hangata. Leha ho le joalo, ho na le liphapang lipakeng tsa li-ICD le OCD (mohlala, tšusumetso kapa takatso ea naha e bonoang ho li-ICD, boleng ba hedonic nakong ea ts'ebetso ea boitšoaro ba ICD, le botho bo batlang maikutlo bo atisang ho bonoa ho batho ba nang le ICD) [7]. Leha ho na le phapano lipakeng tsa li-ICD le OCD, lintlha tsa ho qobelloa li bonoe ka ho ikamahanya le li-ICD, 'me tlhaiso-leseling e fana ka maikutlo a hore likarolo tsa ho qobella, hammoho le ho tsilatsila, li ka emela lipheo tsa bohlokoa tsa kalafo ho li-ICD tse ling.

Litsela tsa nakong e tlang

Hobane lipatlisiso li na le moeli, 'me liphetho li fapane, ho bonahala eka li tlil'o pele ho nako ho tsebahatsa li-ICD le OCD haholo. Hore na ho na le li-ICD kapa li-subtypes tse ikhethang tsa ICD tse amanang haufi haholo le OCD ho ntse ho lokela ho hlahlojoa ka mokhoa o hlakileng. Ntle le moo, ho aha ho qobelloang joalo ka ha ho amana le li-ICD le li-waranti tsa OCD ho etsa lipatlisiso tse eketsehileng ho tseba ho ts'oana le ho fapana le ho hlahloba sephetho sa maano a thibelo le kalafo. Mohlala, ka lebaka la hore kalafo ea li-ICD tse nang le li-SRI e bonts'itse liphetho tse fapaneng, lipatlisiso tsa nako e tlang lia hlokahala ho bona hore na li-subgroups tse itseng (mohlala, batho ba nang le PG ba nang le likarolo tse ikhethang tsa ho qobelloa kapa ho ts'oaroa) ba arabela hantle kapa hampe ho kalafo tse itseng (mohlala, Li-SRI). Ka mokhoa o ts'oanang, likarolo tse ikhethileng tsa ho qobella li ka supa lipheo tsa ho kenella ka boits'oaro bakeng sa li-ICD. Boithuto ba bioloji ba bokamoso ba li-ICD (mohlala, liphatsa tsa lefutso, neuroimaging) le tsona li tlameha ho kenyelletsa mehato ea ho qobelloa ho utloisisa haholoanyane ho amana ha eona le mathata a sebono sa OC.

Mongolo o botlaaseng ba leqephe

Mosebetsi ona o tšehelitsoe ke chelete e tsoang ho National Institute of Mental Health (K23 MH069754-01A1) ho Dr. Grant.

References

1. Moeller FG, Barratt ES, Dougherty DM, et al. Mehopolo ea kelello ea ho susumetsoa ke matla. Ke J Psychiatry. 2001; 158: 1783-93. [E fetotsoe]
2. Mokhatlo oa American Psychiatric Association. Tlhatlhobo le tlhaiso-leseling ea liphatlalatso tsa kelello. 4. Washington (DC): American Psychiatric Association Press; 2000.
3. Godlstein RZ, Volkow ND. Bokhoba ba lithethefatsi le motheo oa eona oa motheo oa neurobiological: Bopaki ba neuroimaging ba ho kenya letsoho mokokotlong oa pele. Ke J Psychiatry. 2002; 159: 1642-52. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
4. Hollander E. Litšitiso tse bonts'ang maikutlo tse hlokisang botsitso: kakaretso. Psychiatr Ann. 1993; 23: 355-8.
5. Argo TR, e ntšo DW. Litšobotsi tsa Kliniki. Ka: Grant JE, Potenza MN, bahlophisi. Ho becha ka tsela ea tlhaho: tataiso ea kalafo. Washington (DC): American Psychiatric Publishing, Inc .; 2004. maq. 39-53.
6. Ibanez A, Blanco C, Moreryra P, et al. Phapang pakeng tsa bong le papali ea papali ea chelete J Clin Psychiatry. 2003; 64: 295-301. [E fetotsoe]
7. Grant JE, Potenza MN. Mathata a taolo ea tšusumetso: litšobotsi tsa kliniki le tsamaiso ea meriana. Ann Clin Psychiatry. 2004; 16: 27-34. [E fetotsoe]
8. Potenza MN, Leung HC, Blumberg HP, et al. Phuputso ea mosebetsi oa fMRI Stroop ea ts'ebetso ea methapo ea methapo ea methapo ea methapo ho ho becha ha litho tsa botšehali. Ke J Psychiatry. 2003; 160: 1990-4. [E fetotsoe]
9. Grant JE, Kim SW. Lipalo tsa batho ba bangata le ba bongaka ba 131 ea ba bechang. J Clin Psychiatry. 2001; 62: 957-62. [E fetotsoe]
10. Ladd GT, Petry NM. Phapang pakeng tsa batho ba bong bo fapaneng ba batlang ho fumana kalafo. Clin Psychopharmacol. 2002; 10: 302-9. [E fetotsoe]
11. DW e ntšo, Moyer T. Litlhare tsa kliniking le li-comorbidity tsa kelello tsa lithuto tse nang le boitšoaro ba ho becha ba pathological. Sebeletso sa Psychiatr. 1998; 49: 1434-9. [E fetotsoe]
12. Crockford DN, el-Guebaly N. Psorchiatric comorbidity ho tsibollo ea methapo ea methapo: tlhahlobo e boima. Na J Psychiatry. 1998; 43: 43-50. [E fetotsoe]
13. Cunningham-Williams RM, Cottler LB, Compton WM, III, et al. Ho nka menyetla: bothata ba ho becha le mathata a bophelo bo botle ba kelello-li hlahisoa ke thuto ea St. Louis Epidemiologic Catchment Area. Ke J Bophelo bo Botle ba Setjhaba. 1998; 88: 1093-6. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
14. Fontenelle LF, Mendlowicz MV, Versiani M. Ts'usumetso ea taolo ea mafu ho bakuli ba nang le bothata bo potelletseng. Psychiatr Clin Neurosci. 2005; 59: 30-7. [E fetotsoe]
15. Matsunaga H, Kiriike N, Matsui T, et al. Mathata a ho potlakisa ho bakuli ba baholo ba Japane ba nang le lefu la ho sheba lintho habonolo. Compr Psychiatry. 2005; 46: 43-9. [E fetotsoe]
16. Grant JE, Mancebo MC, Pinto A, et al. Tšusumetso ea taolo ea maikutlo ho batho ba baholo ba nang le ts'oaetso e poteletseng. J Psychiatr Res. ka khatiso.
17. Hollander E, Stein DJ, Kwon JH, et al. Ts'ebetso ea kelello le litšenyehelo tsa moruo tsa pherekano e bonahalang habonolo. CNS Spectr. 1997; 2: 16-25.
18. Bienvenu OJ, Samuels JF, Riddle MA, et al. Kamano ea bokuli bo likhathatso bo sa bonahaleng ba likoluoa ​​tse ka hlahang: litholoana tsa thuto ea lelapa. Psychology ea Biol. 2000; 48: 287-93. [E fetotsoe]
19. Black DW, Moyer T, Schlosser S. Boleng ba bophelo le nalane ea lelapa papaling ea papali ea chelete. J Nerv Ment Dis. 2003; 191: 124-6. [E fetotsoe]
20. Tavares H, Zilberman ML, Hodgins DC, et al. Ho bapisa ho lakatsa lipakeng tsa papali ea papali ea chelete le ba lemaletseng joala. Mofuta Oa Kliniki 2005; 29: 1427-31. [E fetotsoe]
21. Blaszczynski A. Ho becha ho hoholo le ho se sebetse hantle ha bobebe ponong. Psychol Rep. 1999; 84: 107-13. [E fetotsoe]
22. Blanco C, Grant J, Potenza MN, et al. Ho potlaka le ho qobella ho ts'oaroa hoa marang-rang [Litšeho] San Juan (Puerto Rico): K'holejeng ea Mathata a ho Ikhoba Khafetsa; 2004.
23. Sanavio Mehopolo le likhothatso: Patua Inventory. Behav Res Ther. 1988; 26: 169-77. [E fetotsoe]
24. Potenza MN, Steinberg MA, Skudlarski P, et al. Litlhaselo tsa papali ea papali ea papali ea papali ea chelete: thuto ea maiketsetso e sebetsang. Psychology ea Arch Gen. 2003; 60: 828-36. [E fetotsoe]
25. Saxena S, Rauch SL. Ts'ebetso ea ts'ebetso ea ho sebetsa ka neuroimaging le neuroanatomy ea ho se bonehale habonolo le khatello ea kelello. Psychiatr Clin North Am. 2000; 23: 563-86. [E fetotsoe]
26. Hollander E, DeCaria CM, Finkell JN, et al. Teko ea crossover ea blind-blind e sa sebetseng hantle e sa sebetseng ka ho sa feleng. Psychology ea Biol. 2000; 47: 813-7. [E fetotsoe]
27. Kim SW, Grant JE, Adson DE, et al. Phuputso e laoloang ke mahlo-habeli e sa sebetseng hantle ea ho sebetsa hantle le polokeho ea paroxetine kalafong ea papali ea ho becha. J Clin Psychiatry. 2002; 63: 501-7. [E fetotsoe]
28. Blanco C, Petkova E, Ibanez A, et al. Phuputso e laoloang ke mofofisi oa sefofane ea fluvoxamine bakeng sa papali ea papali ea methapo. Ann Clin Psychiatry. 2002; 14: 9-15. [E fetotsoe]
29. Grant JE, Kim SW, Potenza MN, et al. Paroxetine kalafo ea ho becha ha methapo ea methapo: teko e laoloang ka bongata e ikemetseng. Int Clin Psychopharmacol. 2003; 18: 243-9. [E fetotsoe]
30. Grant JE, Potenza MN, Hollander E, et al. Patlisiso e ngatafatsang ea mohanyetsi oa opioid nalmefene kalafong ea papali ea ho becha. Ke J Psychiatry. 2006; 163: 303-12. [E fetotsoe]
31. Kim SW, Grant JE, Adson DE, et al. Boithuto ba naltrexone bo sa boneng mahlo le boithuto ba placebo kalafong ea papali ea papali ea chelete. Psychology ea Biol. 2001; 49: 914-21. [E fetotsoe]
32. Hodgins DC, Petry NM. Phekolo ea boits'oaro le boits'oaro. Ka: Grant JE, Potenza MN, bahlophisi. Ho becha ka tsela ea tlhaho: tataiso ea kalafo. Washington (DC): American Psychiatric Publishing, Inc .; 2004. maq. 169-87.
33. Simpson HB, Fallon BA. Bofokoli bo hlokisang botsitso: kakaretso. J Psychiatr Itloaetse. 2000; 6: 3-17. [E fetotsoe]
34. Sylvain C, Ladouceur R, Boisvert JM. Phekolo ea kelello le ea boitšoaro ea papali ea papali ea methapo: thuto e laoloang. Jonana Clin Psychol. 1997; 65: 727-32. [E fetotsoe]
35. Ladouceur R, Sylvain C, Boutin C, et al. Phekolo ea kelello ea ho becha ha methapo ea methapo. J Nerv Ment Dis. 2001; 189: 774-80. [E fetotsoe]
36. Eucheburua E, Baez C, Fernandez-Montalvo J. Ho bapisa katleho ea mekhoa e meraro ea phekolo ho kalafo ea kelello ea papali ea methapo ea mali: sephetho sa nako e telele. Psychology ea Behav Cog 1996; 24: 51-72.
37. Petry NM. Ho becha ka tsela ea tlhaho: etiology, comorbidity, le kalafo. Washington, DC: Mokhatlo oa American Psychological; 2005.
38. Dickerson M, Hinchy J, England SL. Phekolo e nyane le ba betang mathata: lipatlisiso tsa pele. J Gambl Stud. 1990; 6: 87-102. [E fetotsoe]
39. Hodgins DC, Currie SR, el-Guebaly N. Khothaletso e khothatsang le kalafo ea ho ithusa bakeng sa papali ea chelete. Jonana Clin Psychol. 2001; 69: 50-7. [E fetotsoe]
40. McConaghy N, Armstrong MS, Blaszczynski A, et al. Papiso e laoloang ea mefuta e fapaneng ea kalafo le takatso e matla ea papali ea papali ea chelete. Br J Psychiatry. 1983; 142: 366-72. [E fetotsoe]
41. McConaghy N, Blaszczynski A, Frankova A. Ho bapisoa ha boitlamo ba ho nahana le mekhoa e meng ea kalafo ea ts'ebetso ea papali ea papali ea methapo: ho latela lilemo tse peli ho isa ho tse robong. Br J Psychiatry. 1991; 159: 390-3. [E fetotsoe]
42. Christenson GA, Pyle RL, Mitchell JE. Khakanyo e atileng ea bophelo ba trichotillomania ho baithuti ba koleche. J Clin Psychiatry. 1991; 52: 415-7. [E fetotsoe]
43. Christenson GA, Mansueto CS. Trichotillomania: Litšobotsi tse hlalosang le phenomenology. Ka: Stein DJ, Christenson GA, Hollander E, bahlophisi. Trichotillomania. Washington (DC): American Psychiatric Publishing, Inc; 1999. maq. 1-42.
44. Stanley MA, Cohen LJ. Trichotillomania le lefu le bonang habonolo. Ka: Stein DJ, Christenson GA, Hollander E, bahlophisi. Trichotillomania. Washington (DC): American Psychiatric Publishing, Inc; 1999. maq. 225-61.
45. Switzerlando SE, Leonard HL. Trichotillomania: na ke bofokoli bo bonahalang ba tšohanyetso bo hlahang? Psychiatr Clin North Am. 1992; 15: 777-90. [E fetotsoe]
46. Regier DA, Kaelber CT, Roper MT, et al. Teko ea bongaka ea ICD-10 ea likotsi tsa kelello le boits'oaro: liphetho tsa Canada le United States. Ke J Psychiatry. 1994; 151: 1340-50. [E fetotsoe]
47. Du Toit PL, van Kradenburg J, Niehaus D, et al. Papiso ea bosholu ba kelello bo pepesehang ho bakuli ba nang le mathata a tšohanyetso a nang le tšusumetso ea maikutlo a sebelisoang ke lingaka tse sebelisang tlhahlobo ea bongaka e hlophisitsoeng. Compr Psychiatry. 2005; 42: 291-300. [E fetotsoe]
48. Schlosser S, Black DW, Blum N, et al. Pale ea demogology, phenomenology le nalane ea malapa a batho ba 22 ba nang le ho hula moriri ka thata. Ann Clin Psychiatry. 1994; 6: 147-52. [E fetotsoe]
49. Switzerlando SE, Leonard HL, Rapoport JL, et al. Papiso e nang le mahlo a mabeli ea Clomipramine le desipramine kalafong ea trichotillomania (ho hula moriri) N Engl J Med. 1989; 321: 497-501. [E fetotsoe]
50. Christenson GA, Mackenzie TB, Mitchell JE, et al. Phuputso e laoloang, e sa sebetseng hantle, e sa boneng mahlo, ea "fluoxetine" trichotillomania. Ke J Psychiatry. 1991; 148: 1566-71. [E fetotsoe]
51. O'Sullivan RL, Christenson GA, Stein DJ. Pharmacotherapy ea trichotillomania. Ka: Stein DJ, Christenson GA, Hollander E, bahlophisi. Trichotillomania. Washington (DC): American Psychiatric Publishing, Inc; 1999. maq. 93-123.
52. Streichenwein SM, Thornby JI. Teko ea nako e telele, e foufetseng hape e sa laoloeng ke sebaka, e sebetsang hantle ea fluoxetine bakeng sa trichotillomania. Ke J Psychiatry. 1995; 152: 1192-6. [E fetotsoe]
53. Christenson GA, Popkin MK, Mackenzie TB, et al. Phekolo ea Lithium ea ho kuta moriri ka nako e telele. J Clin Psychiatry. 1991; 52: 116-20. [E fetotsoe]
54. Corrigan PW, Yudofsky SC, Silver JM. Litlhare tsa kalafo le boits'oaro bakeng sa litlatsetso tse matla tsa kelello. Hosp Community Psychiatry. 1993; 44: 125-33. [E fetotsoe]
55. Azrin NH, Nunn RG, Frantz SE. Phekolo ea ho kuta moriri (trichotillomania): boithuto bo bapisoang ba ho ikoetlisa khafetsa le boikoetliso bo bobe. J Behav Ther Exp Psychiatry. 1980; 11: 13-20.
56. Woods DW, Wetterneck CT, Flessner CA. Tlhahlobo e laoloang ea ho amohela le kalafo ea boitlamo hammoho le phetoho ea tloaelo bakeng sa trichotillomania. Behav Res Ther. 2006; 44: 639-56. [E fetotsoe]
57. Grant JE, Kim SW. Litšoaneleho tsa kliniki le psychopathology e amanang le bakuli ba 22 ba nang le kleptomania. Compr Psychiatry. 2002; 43: 378-84. [E fetotsoe]
58. McElroy SL, Mopapa HG, Hudson JI, et al. Kleptomania: tlaleho ea linyeoe tsa 20. Ke J Psychiatry. 1991; 148: 652-7. [E fetotsoe]
59. Grant JE, Kim SW. Litšusumetso tse matla le tikoloho ea tikoloho ho kleptomania. Compr Psychiatry. 2002; 43: 223-9. [E fetotsoe]
60. Bayle FJ, Caci H, Millet B, et al. Psychopathology le comorbidity ea mafu a kelello ho bakuli ba kleptomania. Ke J Psychiatry. 2003; 160: 1509-13. [E fetotsoe]
61. Grant JE. Nalane ea lelapa le ho hlaseloa ke kelello comorbidity ho batho ba nang le kleptomania. Compr Psychiatry. 2003; 44: 437-41. [E fetotsoe]
62. McElroy SL, Hudson JI, Mopapa HG, et al. DSM-III-R tšusumetso ea taolo ea tšusumetso e seng kae kapa kae e boletsoeng: litšobotsi tsa kliniki le kamano ho mafu a mang a kelello. Ke J Psychiatry. 1992; 149: 318-27. [E fetotsoe]
63. Presta S, Maraziti D, Dell'Osso L, et al. Kleptomania: Litšobotsi tsa kliniki le ho hlonepha ka sampole ea Italy. Compr Psychiatry. 2002; 43: 7-12. [E fetotsoe]
64. Grant JE, Levine L, Kim D, et al. Phokotso ea taolo ea tšusumetso ho lipilisi tsa kelello tsa batho ba baholo. Ke J Psychiatry. 2005; 162: 2184-8. [E fetotsoe]
65. Grant JE. Buka ea bongaka ea mathata a ho laola tšusumetso. Ho: Hollander E, Stein DJ, bahlophisi. Kleptomania. Washington (DC): American Psychiatric Publishing, Inc .; 2005.
66. Grant JE, Kim SW. Boithuto bo bulehileng ba iletrexone kalafong ea kleptomania. J Clin Psychiatry. 2002; 63: 349-56. [E fetotsoe]
67. Goldman MJ. Kleptomania: ho etsa kelello. Ke J Psychiatry. 1991; 148: 986-96. [E fetotsoe]