Curr Top Behav Neurosci. 2016 Dec 24. Doi: 10.1007 / 7854_2016_57
James MH1,2, Mahler SV3, MOorman DE4, Aston-Jones G5.
inahaneloang
Lilemong tse leshome tse fetileng, laboratori ea rona e fane ka bopaki ba pele bo tobileng bo hokahanyang orexin / hypocretin ho supa le ho batla lithethefatsi ka ho bonts'a hore ts'ebetso ea li-neuron tsena e khothaletsa boits'oaro bo batloang ke morphine. Lilemong tse fetileng, menehelo e tsoang ho bafuputsi ba bangata e senotse likarolo tsa li-orexin tse lemaletseng lithethefatsi tsohle tsa tlhekefetso tse lekiloeng, empa feela tlasa maemo a khethiloeng. Haufinyane tjena re sa tsoa etsa tlhahiso ea hore li-orexin li phethe karolo ea mantlha ho hokahanya "ts'ebetso ea ts'usumetso" tlasa maemo a mangata a boits'oaro, 'me mona re manolla khopolo ena joalo ka ha e sebetsa ho lemalla lithethefatsi. Re hlalosa bopaki bo bokelletsoeng lilemong tse 10 tse fetileng bo hlalosang karolo ea orexin ho batleng lithethefatsi tlasa maemo ao ho hlokahalang boiteko bo matla ho fumana sethethefatsi, kapa ha tšusumetso ea moputso oa lithethefatsi e eketsoa ke boteng ba tšusumetso e kantle joalo ka lithethefatsi lintlha / maemo kapa khatello ea maikutlo. Bopaki bo tsoang liphuputsong tse sebelisang mekhoa ea boipheliso le mekhoa ea ho khutlisa, hammoho le boits'oaro ba moruo ba boits'oaro ba tlhekefetso ea lithethefatsi, bo hlakisa karolo ea orexin molemong oa ho susumetsa, ho fapana le likarolo tsa mantlha tsa matlafatso a lithethefatsi. Re boetse re tšohla khokahanyo ea anatomical ea sistimi ea orexin ka tšusumetso e pharalletseng le lipotoloho tsa moputso, ka ho shebisisa haholo hore na orexin e tsamaisa li-prefrontal le tse ling tse kenang ho glutamatergic joang sebakeng sa ventral tegmental sebakeng sa dopamine neurons. Kamora nako, re lebelletse lilemo tse leshome tse tlang tsa lipatlisiso sebakeng sena, ho totobatsa tumello ea haufinyane ea FDA ea mohanyetsi oa orexin receptor suvorexant (Belsomra®) bakeng sa kalafo ea ho hloka boroko e le sesupo se ts'episang sa ts'ebeliso ea bongaka ea ts'ebeliso ea litlhare tse thehiloeng ho orexin bakeng sa kalafo ea ho lemalla.
LINKOTSO:
Tlatsetso; Joala; Moruo oa boitšoaro Cocaine; Dopamine; Lithethefatsi tsa tlhekefetso; Glutamate; Heroin; Hypocretin; Ho susumetsa; Orexin; Moputso; VTA
PMID: 28012090
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