ACS Chem Neurosci. 2015 Jan 21; 6 (1): 138-46. Doi: 10.1021 / cn500246j. Epub 2014 Dec 11.
Khosana CD1, Rau AR, Yorganson JT, España RA.
inahaneloang
Bopaki bo pharaletseng bo fana ka maikutlo a hore li-hypocretins / orexins li susumetsa ntlafatso ea koae le dopamine ho supa ka liketso ho hypocretin receptor 1.
Ha ho bapisoa, ho kenya letsoho ha hypocretin receptor 2 meputsong ea moputso le matlafatso e amohetse tlhokomelo e nyane. Kahoo, leha ho na le bopaki bo bong ba hore hypocretin receptor 2 e laola tšebeliso ea lithethefatsi tse ling tsa tlhekefetso, hajoale ha ho hlake hore na hypocretin receptor 2 e nka karolo joang taolong ea dopamine ho saena kapa ho ipusa ea koae, haholoholo tlasa maemo a phahameng a boiteko. Ho sebetsana le sena, re ile ra hlahloba litlamorao tsa hypocretin receptor 1, le / kapa hypocretin receptor 2 blockade ho dopamine ho saena le ho matlafatsoa ha koae. Re sebelisitse ho vivo fast scan cyclic voltammetry ho hlahloba litlamorao tsa hypocretin antagonists ho dopamine signing in the nucleus accumbens konokono le kemiso e tsoelang pele ea tekolo ea ho hlahloba litlamorao tsa bahanyetsi bana mabapi le taolo ea koae. Liphetho li bonts'a hore blockade of hypocretin receptor 1 kapa li-hypocretin receptor 1 le 2 li fokotsa haholo litlamorao tsa cocaine e tsoang ho dopamine signaling mme e fokotsa ts'usumetso ea ho nka cocaine. Ho fapana le hoo, blockade ea hypocretin receptor 2 feela e ne e se na litlamorao tse kholo ho saena dopamine kapa ho itaola.
Liphumano tsena li bonts'a karohano e fapaneng ea li-receptor tse peli tsa hypocretin, le hypocretin receptor 1 e bonahala e ameha haholo ho feta hypocretin receptor 2 taolong ea dopamine ho saena le tsamaiso ea 'mele ea koae. Ha ho nahanoa ka lingoliloeng tse seng li ntse li le teng, datha tsena li tšehetsa tšusumetso eo hypocretins e fanang ka eona e nang le tšusumetso e lumellang ho dopamine ho saena le boitšoaro bo khothalletsoang ka liketso tse ikhethileng ho hypocretin receptor 1.
;
