J Neurosci. 2015 Apr 29; 35 (17):6639-53. doi: 10.1523/JNEUROSCI.4364-14.2015.
Navarro G1, Quiroz C2, Moreno-Delgado D1, Sierakowiak A2, McDowell K2, Moreno E1, Rea W2, Cai NS2, Aguinaga D1, Howell LA3, Hausch F4, Cortés A1, Mallol J1, Casadó V1, Lluís C1, Canela EI1, Ferré S5, McCormick PJ6.
inahaneloang
Ho lokolloa ha neuropeptides corticotropin-releasing factor (CRF) le orexin-A sebakeng sa ventral tegmental (VTA) ho bapala karolo ea bohlokoa boits'ebetsong ba ho batla khatello ea koae. Re fana ka bopaki bakeng sa tšebelisano-'mano ea bohlokoa lipakeng tsa CRF le orexin-A tse itšetlehileng ka oligomerization ea CRF1 receptor (CRF1R) le li-receptor tsa Orexin OX1 (OX1R). CRF1R-OX1R heteromers ke lisosa tsa crosstalk e mpe lipakeng tsa orexin-A le CRF joalo ka ha ho bonts'itsoe liseleng tse fetisitsoeng le rat VTA, eo ho eona ba fetolang ka matla dendamine ea dendamine. The cocaine target target1 receptor (σ1R) e boetse e ikamahanya le CRF1R-OX1R heteromer. Cocaine e tlamang mochini oa σ1R-CRF1R-OX1R e khothalletsa tšitiso ea nako e telele ea orexin-A-CRF negative crosstalk.
Ka mochine ona, cocaine e lematsa lisele tsa VTA ka litlamorao tse khahlisang tsa CRF le orexin-A, ka tsela ena, e fana ka mochine o hatelletsang ho batla koae.
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