Br J Pharmacol. 2015 Jan;172(2):334-48. Doi: 10.1111 / bph.12639. Epub 2014 Jul 1.
Baimel C1, Bartlett SE, Chiou LC, Lawrence AJ, Muschamp JW, Patkar O, Tung LW, Borgland SL.
inahaneloang
Bokhoba ba tahi ke lefu le bohloko le amang batho ba limilione tse 15.3 lefatšeng ka bophara. Le ha e atile, ke mekhoa e fokolang ea kalafo e teng. Ho amohetsoe li-receptor tsa Orexin e le sepheo sa sepheo sa meriana e thibelang takatso. Li-Orexins, tse tsejoang hape e le li-hypocretins, ke li-neuropeptides tse hlahisoang ke li-neuron tsa lateral le dorsomedial hypothalamus le sebaka se mahareng, se hlahisang hohle bokong. Ho ba sieo ha li-orexine ka litoeba le batho ho lebisa ho narcolepsy. Leha ho le joalo, li-orexin le tsona li na le karolo e tsebahalang ho batleng meputso. Tlhatlhobo ena e tla tšohla tse ling tsa lithuto tsa mantlha tse hlalosang karolo ea li-orexine molemong oa ho batla meputso le mesebetsi e ikhethileng e hlahisitsoeng Kopanong ea Machabeng ea Patlisiso ea Lithethefatsi ea 2013. Letšoao la Orexin le ka khothaletsa polasetiki e bakoang ke lithethefatsi ea li-synapses tsa glutamatergic ho li-dopamine neurons tsa sebaka sa ventral tegmental (VTA), sebaka sa boko se amehang boitšoarong bo susumetsang. Bopaki bo bong bo fana ka maikutlo a hore lets'oao la orexin le lona le ka khothaletsa ho batla lithethefatsi ka ho qala khatello ea maikutlo ea endocannabinoid-mediated ea maiketsetso a GABAergic ho VTA, ka hona e thibela li-neuron tsa dopaminergic. Li-Orexin neurons li hlahisa co-inhibitory opioid peptide dynorphin. Ho 'nile ha hlahisoa hore orexin ho VTA e kanna ea se ke ea kenella moputsong ka mong, empa e hlahise litlamorao tsa' anti-moputso 'tsa dynorphin. Kamora nako, ho saena ha orexin ho cortex ea pele le ho amygdala e bohareng ho kenyelelitsoe ho khutlisetsong ea ho batla moputso. Tlhatlhobo ena e tla totobatsa mosebetsi oa haufinyane o hlalosang karolo ea ho tšoaea orexin lits'ebetsong tsa lisele tse nang le boits'oaro bo amanang le bokhoba le ho sisinya likhopolo-taba tsa lipale tsa mekhoa eo orexin e ka fanang ka eona e ka fanang ka ho batla lithethefatsi.
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