J Neurosci. 2015 May 6; 35 (18):7295-303. doi: 10.1523/JNEUROSCI.4385-14.2015.
Baimel C1, Borgland SL2.
inahaneloang
Dopamine neurons e sebakeng sa ventral tegmental (VTA) ke sepheo sa mantlha sa lithethefatsi tse lemalloang, 'me neuroplasticity tikolohong ena e ka tlasa lintlha tse ling tsa mantlha tsa bokhoba ba tahi. Ho tloha ponong ea pele feela, lithethefatsi tsohle tsa tlhekefetso li kenya polasetiki ea synaptic ho VTA. Leha ho le joalo, ha ho utloisisoe hantle hore na sehlopha sena se fapaneng sa lithethefatsi se tlisa phetoho e tloaelehileng ea synaptic joang.
Orexin (e tsejoang hape ka hore ke hypocretin) ke "hypothalamic neuropeptide" ea morao-rao e hlahisitsoeng ho VTA e khothalletsang boitšoaro bo batlang lithethefatsi mme e ka fetisetsa phetisetso ea synaptic e fetisang ho VTA dopamine neurons.
Mona re bontša hore ho saena ho orexin receptor mofuta 1 (OxR1) ho VTA ho hlokahala bakeng sa polasetiki e hlahisang morphine e hlahisang dopamine neurons. Tsamaiso ea systemic kapa intra-VTA ea OxR1 antagonist SB 334867 ka likhoto li thibetse keketseho e khothalletsoang ke morphine ho karolelano ea AMPAR / NMDAR, keketseho ea tlhahiso ea "presynaptic glutamate" le phetoho ea postynaptic ea palo ea AMPAR kapa ts'ebetso, ho kenyelletsa phetoho ea sebopeho sa subunit. . Ho feta moo, SB 334867 e thibetse ho theoha ha morphine ho tlisoang ke Presphaptic GABA, le phetoho e tlatselitseng morphine tekong ea thabo le liphihlelo tsa thibelo ea methapo ea kutlo.
Liphumano tsena li hlahisa karolo e phethoang ea orexin ho polasetiki e kentsoeng morphine ho VTA mme e fana ka mochine oo ka oona orexin e ka hlahisang tlhahiso ea li-neuron tsa dopamine.
LINKOTSO:
AMPA; NMDA; dopamine; morphine; orexin; tikoloho e khelohileng ea moea
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