Physiology ea orexinergic / hypocretinergic system: e khutlisetsoa ho 2012.

Li-orexins tsa neuropeptides le li-receptor tsa tsona tsa G protein-coupled, OX (1) le OX (2), li fumanoe ho 1998, mme ho tloha ka nako eo, karolo ea bona e fuputsoe mesebetsing e mengata e kopantsoeng ke tsamaiso ea methapo ea methapo, ho kenyelletsa ho robala le ho tsoha, takatso ea lijo / metabolism, karabelo ea khatello ea maikutlo, moputso / ho lemalla, le analgesia. Li-Orexins le tsona li na le liketso tsa phello ea bohlokoa bo sa hlakileng ba 'mele. Likarabo tsa cellular mosebetsing oa li-orexin receptor li fapane haholo. Li-receptors li nyala bonyane malapa a mararo a liprotheine tsa heterotrimeric G le liprotheine tse ling tse qetellang li laola likarolo tse kang phospholipases le kinases, tse amang ho chesoa ha neuronal, polasetiki ea synaptic, le lefu la sele. Sengoliloeng sena ke tlhahiso ea selemo sa 10 sa tlhahlobo ea ka e fetileng mabapi le physiology ea tsamaiso ea orexinergic / hypocretinergic. Ke batla ho fana ka tlhaiso-leseling e phethahetseng ea 'mele oa orexin o tlohang ho libapali tsa limolek'hule tse orexin receptor o bonts'a likarabo tsa tsamaiso empa o ntse o hatisa likarolo tsa mmele oa tsamaiso ena.