Eur J Pharm Sci. 2014 Jun 16;57:2-10. doi: 10.1016/j.ejps.2014.01.008. Epub 2014 Jan 25.
Quarta D1, Smolders I2.
inahaneloang
Hypothalamus ke mokhoa o kopantsoeng oa ho utloa matla o hokahaneng le likarolo tse phahameng tsa ts'usumetso ea mesocorticolimbic dopamine (DA) system. Khokahano ena e laoloa ka thata ke li-neuropeptides tse ngata tsa orexigenic hypothalamic, ho kenyeletsoa haholo-holo ghrelin, orexin le neuropeptide Y (NPY), e nolofalletsang ea morao-rao ho hlophisa liketsahalo tsa bohlokoa tsa li-reinforcers tsa tlhaho le tsa lik'hemik'hale. Tlhahlobisong ena re ikemiselitse ho sekaseka tsebo ea hajoale mabapi le litsamaiso tsena tse tharo tsa orexigenic neuropeptide tse amehang taolong ea DAergic ea boitšoaro ba psychostimulant. Re tla qala ho hlahloba litšebelisano tse teng pakeng tsa ghrelin, orexin le NPY ka har'a li-nuclei tsa hypothalamic. Ka mor'a moo re tla hlalosa hore na li-neuropeptide tsena li ka ama DAergic neurotransmission ka ho laola sekhahla sa ho thunngoa ha li-neuron tsa DA sebakeng sa ventral tegmental (VTA) kapa ka ho sebelisana ka pele ho li-terminals tsa methapo ea DAergic. Qetellong, re tla totobatsa lithuto tsa mantlha tse hlalositseng ho kenya letsoho ha ghrelin, orexin le NPY ka thepa e putsang, e matlafatsang le e khothatsang ea li-reinforcers tsa tlhaho le lithethefatsi tsa tlhekefetso. Tšebelisano ea hypothalamic ea ghrelin, orexin le NPY e kanna ea emela pono e ncha ea mantlha mabapi le mekhoa ea neuronal e laolang boits'oaro ba bokhoba bo bolokiloeng ke sistimi ea DA.
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