Ho hlōloa ha liphoofolo mohlala oa ho tepella maikutlo ho bontša hore orexin e fokotsehile libakeng tsa mesocortical ea dopamine system, le ea dynorphin le orexin hypothalamus (2012)

Anhedonia ke letšoao la mantlha la khatello ea maikutlo tleliniking. Li-neuropeptide tse peli tsa boko tse 'nileng tsa kenella ho matšoao a anhedonia mefuteng ea khatello ea maikutlo ea preclinical ke dynorphin le orexin; e tsepamisitsoeng hammoho tseleng ea moputso oa morao-rao oa hypothalamic dopamine. Tsena li ama taolo ea methapo ea kutlo ea methapo e lekanyetsang tšebetso ea e mong, e leng se bontšang ho se sebetse ho kopanetsoeng lipakeng tsa bona le matšoao a anhedonia.

Empa hore na litšusumetso tsa bona li fetotsoe kapa li sa leka-lekane kahare ho tsamaiso ea hypothalamus kapa dopamine mefuteng ea khatello ea maikutlo ea anhedonic ha e e-so hlake.

Re sebelisitse radioimmunoassay ho tseba sena molemong oa peto ea sechaba ea khatello ea maikutlo; ka nako eo ho neng ho bontšoa ho hloka boithati ka ho kopanela liphate. Mo mefuteng ea lisele ea medial preambilial cortex (mPFC), sebaka sa ventral tegmental (VTA) le nucleus accumbens, maemo a basal dynorphin a ne a tšoana le liphoofolo tse tloaelehileng. Empa orexin e fokotsehile ho VTA le mPFC.

Hape, dynorphin le orexin ka bobeli li ile tsa fokotseha ho hypothalamus e bohlokoa haholo kaha hoo e batlang e le lisele tsohle tsa hypothalamic orexin li sebelisana 'moho le "dynorphin". Liphumano tsena li fana ka maikutlo a hore ts'ebetso ea orexin le dynorphin e kanna ea lekanngoa lipakeng tsa hypothalamus le mesocortical dopaminergic libakeng tsa khatello ea maikutlo.