J Neurosci. 2016 Aug 17;36(33):8700-11. doi: 10.1523/JNEUROSCI.1291-15.2016.
McGlinchey EM1, James MH2, Mahler SV3, Pantazis C.2, Aston-Jones G4.
inahaneloang
Likenyelletso tsa Glutamate ho li-nucleus accumbens (NAc) li nolofalletsa mokhoa o batlang lithethefatsi mme o simoloha ho tsoa medial prefrontal cortex (mPFC), basolateral amygdala (BLA), le subralulum subralulum ea hippocampus (vSub). Tlibaka tsa hese li hlahisa Fos (sesupo sa tšebetso ea neural) nakong ea ha a khutlisetsa bohloka ba ho ts'oara koae, empa ke likarolo tse fokolang feela tsa "neurons" tse libakeng tsena tse tsamaisang ho batla lithethefatsi.
Mokhoa o mong oa ho khetholla le ho khetholla likarolo tsa neural tse kenngoeng nakong ea ho batla lithethefatsi ke ho hlahloba sepheo sa bona. Litšusong, re ile ra hlahloba polelo ea Fos nakong ea ha 'mele oa cocaine o boetse o ts'oara ho ts'oaroa ha k'hok'heine (c), infralimbic cortex (IL), BLA, le li-neuron tsa VSub tse sebetsang ho NAc konokono (NAcC) kapa leqhubu la NAc (NAcSh ). Li-Neurons tse Pl, BLA, le vSub projeke eo e eang ho NAcC, empa eseng NAcSh, e bontšitse Fos nakong eo a neng a batla koae ka koae, empa a sa batle. Leha ho le joalo, ts'ebetso feela ea tsela ea PL-NAcC e kopantsoeng hantle le boikoetliso ba koae ea koae, ho fapana le litlatsetso tsa BLA kapa vSub ho NAcC.
Ho netefatsa karolo e sebetsang bakeng la tsela ea PL-NAcC, le ho leka khopolo-taba ea hore tsela ena e hapuoa ka mokhoa o itšetlehileng ka dopamine, re sebelisitse mokhoa oa ho thibela litokelo tsa bongaka oa bongaka moo dopamine signaling e neng e koetsoe ho PL mme glutamate signaling e ne e koetsoe kontinenteng. NAcC. Khokahano ena e ile ea etsa hore moea oa cocaine o khutlisetsoe hape empa ha oa ka oa ba le phello ea ho khutlisetsoa ha motho ea batlang. Liphetho tsa rona li bonts'a karolo ea tsela ea PL-NAcC tseleng ea ho ts'oara koae 'me e bonts'a hore likhakanyo tsena tsa glutamatergic li nkuoa ka tsela e itšetlehileng ka dopamine ho khanna ho khutlisetsoa.
TLHALOSO EA SIGNIFICANCE:
Ho khutlela morao ho bolela tšitiso ea bohlokoa kalafong e atlehang ea ho lemalla koae. Mona, re tšoaea ts'ebetso e lekanang ea ho kenella ha glutamatergic ho li-bokellase tsa nucleus nakong ea ho khutlisetsoa ha k'hok'heine e ts'oanang le ho tsoma ho batla. Li-prelimbic cortex (PL) tse boletsoeng ho nucleus accumbens core (NAcC) li hlalositse Fos ka mokhoa o ikhethileng o lumellanang hantle le ts'ebeliso ea koae, empa e se mokhoa oa ho ipatlela. Liteko tse eketsehileng tsa ts'ebetso li bonts'itse hore tsela ea PL-NAcC e hiriloe ke likhakanyo tse amanang le lithethefatsi ka mokhoa o itšetlehileng ka dopamine ho khanna ho batla koae, empa eseng ho batla boits'oaro. Lintlha tsena li totobatsa li-neurons tsa PL hore projeke ea NAcC, le melaoana ea tsona ke dopamine, joalo ka liphofu tse ka bang teng bakeng sa kalafo tse reretsoeng ho phekola ho khutlisetsoa ha koae tse sa amang moputso oa tlhaho.
LINKOTSO: basyatal amygdala; koae; dopamine; li-nucleus accumbens; prelimbic cortex; subralulum
PMID: 27535915
DOI: 10.1523 / JNEUROSCI.1291-15.2016
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