Nat Neurosci. 2007 Jan; 10 (1): 93-9. Epub 2006 Dec 3.
Russo SJ1, Bolanos CA, Theobald DE, DeCarolis NA, Renthal W., Kumar A, Winstanley CA, Renthal NE, Tlhaloso ea Wiley MD, Boitšoaro ba DW, Russell DS, RL Rate, Eena AJ, Nestler EJ.
inahaneloang
Tsamaiso ea morphine e sa foleng (ka subcutaneous pellet) e fokotsa boholo ba li-dopamine neurons sebakeng sa ventral tegmental (VTA), sebaka sa moputso oa mantlha bokong, leha ho le joalo motheo oa limolek'hule le litholoana tse sebetsang tsa phello ena ha li tsejoe. Phuputsong ena, re sebelisitse phetiso ea liphatsa tsa vaerase e pakeng tsa likhakanyo ka bongata ho isa hokamoo morphine e kenyang moriti oa morao-rao oa insulin receptor substrate 2 (IRS2) -thymoma viral proto-oncogene (Akt) ea ho supa tseleng tseleng ea VTA e arolelanang ho fokotseha ha boholo ba sele ea dopamine e bonoang kamora ho pepesoa ha morphine le hore ho theoha hona ho fokotsa moputso oa morphine, jwaloka ha e lekantsoe ke khetho ea sebaka Re boetse re bontša hore phokotso ea boholo ba li-neurons tsa VTA dopamine e phehella ho fihlela libeke tse 2 kamora ho tloheloa ha morphine, e tsamaellanang le mamello le litlamorao tse ntle tsa morphine tse bakiloeng ke ho pepeseha ha morphine e sa foleng. Liphumano tsena li kenya molao ka kotloloho tseleng e emisang IRS2-Akt e le molaoli ea thata oa dopamine cell morphology le moputso oa opiate.
;
