LITLHAHISO: Ho tepella ka thobalano ke likhoto ho tšoauoa ka liphetoho tse ngata tsa boko tse nkang bonyane matsatsi a 4 ho khutlisa. Ka nako e ts'oanang, ho hlaphoheloa ka botlalo liketsong tsa thobalano (palo ea lits'oants'o le ejaculations) ho nka matsatsi a 15. Mofuputsi enoa o lumela hore, joalo ka rona, hore ho khotsofatsa thobalano ke mekhoa ea ho thibela ho hlasimoloha ho fetelletseng ha ba potoloho ea moputso.
Ho tsoa thutong: Ho ka nahanoa hore tšitiso ea nako e telele ea thobalano e bakiloeng ke ho kopitsoa ha satiation ke mokhoa o itšireletsang khahlanong le ho tsosa lirafshoa tsa boko tse amehang ts'ebetsong ea tsona. Sisteme ea mesolimbic e bapala karolo ea ts'ebetsong ea meputso ea tlhaho ho kenyelletsa boitšoaro ba thobalano [2]. Ho susumetsa khafetsa ha potoloho ena ka taolo e sa khaotseng ea lithethefatsi tsa tlhekefetso ho hlahisa maikutlo a boits'oaro [16] e tšoanang le lithethefatsi tse matla tse bonts'itsoeng ke litoeba tse felileng ka thobalano kamora ho ts'oaroa khafetsa ka nako e khuts'oane, e neng e tla tsosa ts'ebetso ea mesolimbic kamehla
Behav Brain Res. 2011 Mar 1; 217 (2): 253-60. Doi: 10.1016 / j.bbr.2010.09.014. Epub 2010 Sep 25.
Rodríguez-Manzo G1, Guadarrama-Bazante IL, Morales-Calderón A.
mohloli o moholo
Departamento de Farmacobiología, Cinvestav, IPN-Sede Sur, Calzada de los Tenorios 235, Delegación Tlalpan, México 14330 DF, Mexico. [imeile e sirelelitsoe]
inahaneloang
Likhoto tsa banna li ne li lumella ho koptjoa ntle le lithibelo le ejestate e le 'ngoe ea basali e khahlisang khafetsa ho fihlela e fihla ho tepella. Lihora tse mashome a mabeli a metso e mene ka mor'a ts'ebetso ena, banna ba tona ba kopaneng le thobalano ba bonts'a letoto la liphetoho tsa 'mele ha li bapisoa le ba batona ba sa khathaleng. Har'a tsona, tse makatsang ka ho fetesisa ke boitšoaro bo sa feleng bo amanang le thobalano le tšireletso e akaretsang liketsong tsa lithethefatsi. Morero oa mosebetsi o teng e ne e le ho bona hore na ho na le khokahano pakeng tsa likarolo tsee tse peli tsa thobalano ea thobalano mabapi le nako ea polelo ea eona. Ho fihlela sepheo seo, re bonts'itse ts'ebetso ea ho itlosa bolutu ea thobalano e tsoang boithabisong ba thobalano, le nako ea ketsahalo ea lithethefatsi hypersensitivity. Qetellong ho ile ha hlahlojoa ho hlaha pontšo ea serotonergic syndrome: boemo ba mmele o bataletseng. Liphetho li bonts'itse hore ts'ebetso ea hypersensitivity phenomenon le thibelo ea thobalano e hlahisoang ke ho qaptjoa ho ea ho satiation e latela nako e ts'oanang ea ho hlaphoheloa, ka ho fokotseha ho hoholo ha polelo ea bona ea 96 h kamora ts'ebetso ea ho satiation ea thobalano. Phumano ena e bonts'a hore liketsahalo tsena li ka supa lipontšo tse peli tsa ts'ebetso e le 'ngoe ea boko, joalo ka ha ho khothalelitsoe ke motho oa nako e telele oa liketsahalo tse peli, tseo ho makatsang hore li ka fetoha.
Copyright © 2010 Elsevier BV Litokelo tsohle li sirelelitsoe.
LIPAKI TSA HO ITHUTA KA TSOHLE:
Ho satiation ka thobalano ho hlalosoa e le nako e telele ea thibelo ea thobalano e hlahang kamora ho pheta-pheta khafetsa nakong ea ho qopitsoa ha libitum [2,12]. Lihora tse mashome a mabeli a metso e mene kamora ts'ebetso ea mokhathala, likhoto tsa banna li itshwara ka mekhoa e fapaneng ka bobeli ba mosali ea amohelang molaetsa: likarolo tse peli ho tse tharo ha li bonts'e ts'ebetso efe kapa efe ea thobalano mme karolo ea boraro e setseng e khona ho tsoha hang, ntle le ho qala ts'ebetso ea thobalano kamora moo ejaculation [18]. Kahoo, lipalo tse peli tsa likhoto tse tepelletseng ka thobalano li ka khetholleha 24 h kamora ho qopitsoa ho satiation, e arabelang le e sa arabeleng. Sebakeng sena se lekanang sa liteko (24 h), likhoto tsa banna tse tepelletseng ka thobalano li bonts'a letoto la liphetoho tsa 'mele ha li bapisoa le tse tona tse sa khathaleng.
Mohlala, ts'usumetso ea motlakase ea libaka tsa boko tse kenyelitsoeng taolong ea boitšoaro bo kopanetsoeng joalo ka sebaka sa medial preoptic [23], sebaka sa karolelano ea methapo [20] le li-nucleus accumbens [21] li thusa ho bua ka boitšoaro ba thobalano ho likhoto tsa banna tse nang le boiphihlelo, empa li haella ea sephetho lithutong tse tšoanang ha ho tepelletsoa ka thobalano.
Phetoho e 'ngoe e bua ka phello e tšoenyang eo motho a tloaetseng ho tsoha a e hlalositseng makotatsong a banna a nang le thobalano [9]. Thepa ena ea ejaculation e hlaha kamora 'ngoe, tse peli kapa tse tšeletseng tsa tatellano e latellanang, leha ho le joalo, 24 h kamora ts'ebetso ea ho satiation, hang ha ts'ebetso ea thobalano e thehiloe, ts'ebetso e bontšitsoeng ke sechaba se arabelang sa liphoofolo tse ts'oanang le thobalano, ha se na phello e tšoenyang joaloka "22" ].
Kamora nako, ho fumana ho feto-fetohang ha ho fana ka kalafo ea pharmacological ho litoeba tse felisitsoeng ka thobalano ke pontšo ea hypersensitivity ea lithethefatsi.
Kahoo, likatsong tsa thobalano tse amanang le thobalano serotonergic 5-HT1A receptor agonist, 8-hydroxy-di-propil amino tetraline (8-OH-DPAT), ho kenyelletsa ho khutlisa mokhoa oa ts'ebetso oa thobalano o thibelang banna ba khathetseng, o etsa ponahalo ea matšoao a serotonergic syndrome (5-HT syndrome) [18], kamora tekanyo e sa e qobelle ho liphoofolo tse sa khathaleng [24]. Yohimbine, mohanyetsi oa _2-adrenergic ea tsejoang ho hlahisa litheko tsa biphasic, tse thehiloeng ho litekanyetso tsa litšoene tse nang le bohlola [6], o na le fensetere e senyane bakeng sa litlamorao tsa eona litlamong tse felisitsoeng ke thobalano ho feta ho ba sa khathetseng [18], le phello e tšoanang e bonoa le bahanyetsi ba opioids naloxone le naltrexone [19]. Kamora nako, mohanyetsi oa dopaminergic, haloperidol, o phahamisa boitšoaro bo potolohileng liphoofolong tse felileng ka thobalano ho litekanyetso tse sa hlokeng phello e joalo ho litoeba tse nang le thobalano [17]. Ka bobeli, tlhaiso-leseling ena e fana ka maikutlo a hore hypersensitivity ea liketso tsa lithethefatsi ke ketsahalo e akaretsang ea litoeba tse ts'oanang ka thobalano, kaha e hlaha kamora ts'ebeliso ea systemic ea li-pharmacological tse fapaneng tse sebetsang lits'ebetsong tse fapaneng tsa neurotransmitter
Ka hona, kamora ho rekota ha 24 h, ha ho ne ho se na motho ea nang le karabelo ea botona kapa ea botšehali ea ileng a qobella ho qapa, keketseho e tsoelang pele ea bokhoni ba litoeba tse felileng ka thobalano e ile ea bonoa.
Ka hona, 40% ea likhoto tse satiated e bonts'itsoeng ho 3 e latellanang ejaculations 72 h ka mor'a ts'ebetso ea mokhathala. Peresente ena e ne e phahame haholo ka lipalo ho feta e fumanoeng ho 24 h mme e tlase haholo ha e bapisoa le ts'ebetso ea likhoto tse nang le thobalano nakong ea satiation. Bongata bo fetang ba 4 bo latellanang bo fihlellelitsoe ke likhoto XatiUMX h kamora ho satiation, mme palo ena e ile ea nyolohela ho 96 kamora nako ea matsatsi a 5 ea phomolo ea thobalano.
TŠOHLOA
Tlhahiso-leseling e mabapi le litla-morao tsa boits'oaro ba thobalano kamora ho qopitsoa ho satiation e bonts'a ts'ebetso ea ho hlaphoheloa ka boits'oaro e lokela ho lateloa haholo ka mefuta e meraro: liperesente tsa likhoto tse satiated fihlella ejaculation, karolo ea liphoofolo tsena tse qalang ho qopitsa kamora ho omisoa le mmele Matla a bontšitsoeng ke likhoto ka mor'a linako tse fapaneng tsa phomolo ea thobalano. Liphetho li bonts'a hore nakong ea 48 ea pele ho latela kemiso ea ho khathala, liphoofolo li thibeloa ka mokhoa o hlakileng ka thobalano, le keketseho ea bokhoni ba kemiso (3 e latellanang ea ejotsoations) ka karolo e nyane haholo ea likhoto. Karolo ea banna ba bonts'ang kemiso ena e eketsehang augments 72 h kamora ho satiation. Kamora nako ea phomolo ea thobalano ea 96 h, liphoofolo tsohle li khona ho hula le ho qalella ho kopitsa kamora ho emisoa. Hona ke phetoho ea boleng, hobane mokhoa o neng o sebelisoa ho nka hore moitlami oa liteko o khutlisa takatso ea thobalano ke ho khutlisetsa bokhoni ba likhoto tse qobelloang ho qalella ho qopitsa kamora ho emisoa [18]. Ka hona, ho ka boleloa hore ka nako ena thibelo ea thobalano e khethollang satiation e khutlisoa ho liphoofolo tsohle, tseo kaofela li nang le bokhoni ba ho fumana letoto la lihlooho tse peli tse latellanang. Kamora nako ea matsatsi a 7 ea matsatsi a phomolo ea thobalano, bokhoni ba ejaculatory ba liphoofolo tsohle bo eketseha ho isa 4 e latellanang, ho 5 kamora matsatsi a 10 le 6 kamora matsatsi a 15 a phomolo ea thobalano.
Palo e bolelang palo ea likamano tse latellanang tse bontšitsoeng ke ba batona ba kopaneng le thobalano nakong ea kemiso ho satiation process (tse supileng) e fihlelloa ke halofo ea likhoto tse monate kamora matsatsi a 15 a phomolo ea thobalano. Karolo ena ea ho qetela ha e fapane le e fumanoeng nakong ea ho qopitsoa ho satiation fao ho banna ba sa tepelloang.
Phuputso ea mantlha ea Leoatle le Jordane mabapi le ho tepella ka thobalano [3] e tlalehile nako ea matsatsi a 15 ea ho fola ka botlalo ho tepelletseng ka thobalano e neng e khethiloe ke lipontso nako tse 'maloa tse ikhethileng ka mor'a ho satiation. Lintlha tsa hona joale, li fumanoe li sebelisa lihlopha tse ikemetseng (tse eketsehileng tse ikemetseng) tsa likhoto bakeng sa nako e 'ngoe le e' ngoe ea ts'ebetso ea ho hlaphoheloa, 'me li hlahlobe bokhoni ba e' ngoe le e 'ngoe ea lintlha tsena li sebelisa tlhahlobo ea satiation (90 min ntle le ejamisoating kamora ho omisoa ho ho qetela). Ho khahlisang ke hore, ho sa tsotellehe mekgwa e fapaneng ea ho tepella ka thobalano e sebelisitsoeng lithutong tsena ka bobeli le mekhoa e fapaneng e sebelisitsoeng ho theha nako ea thibelo, sebaka se le seng sa nako se fumanoe se hlokahala bakeng sa ho hlaphoheloa ka botlalo. Kopano ena, hammoho le taba ea hore palo e kholo ea tatellano ea katleho ea 7 le ho eketseha ho fetelletseng ha nako ea kamora-kameho ea morao-rao e bonngoe ka mokhoa o sa fetoheng ha ho arabeloa ka karohano e fapaneng ea ho tona ka thobalano [3,12,18], e fana ka maikutlo a hore tsena kaofela ke lintho tsa bohlokoa likarolo tsa ketso ea ho tepella ka thobalano e hlahang, ka boikemelo ho paradigm e sebelisitsoeng ho tsosa naha ena ea thibelo.
Tšobotsi ea ntlafatso e tsoelang pele ea bokhoni ba 'mele ba' mele ba tlhaho bo boletsoeng mona ke lintlha tse fumanehang tse ka thusang ho theha nako ea litlamorao tsa liteko tsa liteko tse nolofalletsang polelo ea boitšoaro ba thobalano ho likhoto tse felileng ka thobalano le ho tseba tekanyo ea boemo ba inhibitory state phetoho e hlahisitsoeng ho likhoto tlasana le satiety paradigm ea rona e itseng.
Mabapi le ketsahalo ea lithethefatsi tsa hypersensitivity, tlhahlobo ea matšoao a fapaneng a 5-HT-syndrome e senoletse hore FBP ke sesupo se sa fetoheng ka ho fetesisa se hlokometsoeng kamora ho ipapela lipilisi tse tlase tsa 8-OH-DPAT litekong. Hona hape ke pontsho e ntle ka ho fetisisa e bonts'a maikutlo a khethollo ea likhoto tsa banna tse nang le maemo a fapaneng a thobalano.
Joalokaha ho boletsoe pejana, FBP hammoho le ho hatakeloa esale pele ke matšoao a mabeli ao pele a neng a amana le ente ea 8-OH-DPAT likoteng tse sa feteng thobalano, leha e le maemong a holimo a tekanyetso [10]. Leha ho le joalo, litekong tsa rona, lets'oao la ho hatakela esale pele le hlahile nako le nako ho liphoofolo, ntle le boemo ba bona ba thobalano. Liphetho tse khethollang li kanna tsa itšetleha ka litekanyetso tse tlase tsa 5-HT1A agonist e sebelisitsoeng litekong tsa rona. Ho khahlisang ke hore maemong ana a tlase a lethaliti letshwao la hindlimb la lefu la 5-HT, le sa tlalehiloeng pejana ho hlaha ka lebaka la ente ea ip ea 8-OH-DPAT, e hlahisitsoe hoo e batlang e le liphoofolo tsohle tsa boemo bo bong le bo bong ba thobalano mme lebaka e ka ba lona e tšoanang, ke hore, e hlaha feela ka tekanyetso e tlase haholo, ha e hlahlojoe mesebetsing e meng. Phapano ea maikutlo a litheko tse lebelletsoeng pakeng tsa liphoofolo tse nang le thobalano le thobalano e bontšitsoe ka ho hlaka ke pontšo ea FBP, empa ho khahlisang, ho ba teng ha maikutlo a khethollo lipakeng tsa lefu la naïve le litoeba tse nang le thobalano le tsona li ka theha.
Phapang ea kutloisiso ea lithethefatsi lipakeng tsa naïve le thobalano e ts'oanang le thobalano e fihlella taelo e le ngoe ea boholo. Ho tsebo ea rona hona ke tlaleho ea pele ea ho tlaleha hore boiphihlelo ba thobalano bo fetola maikutlo a litoeba liketsong tsa lithethefatsi. Lintlha tsena li re lebisa tlhokomelo litlamorao tsa boiphihlelo ba thobalano ho ts'ebeliso ea boko ho liphoofolo tse kholo. Lilemong tse fetileng palo e ntseng e eketseha ea mesebetsi e rarollotse bothata bona. Kahoo, re ka fumana mesebetsi e tlaleha hore boiphihlelo ba thobalano bo susumetsa steroid hormone secretion [8,29], e eketsang medial preoptic area nitric oxide synthase [7], e fetole mohopolo le ho ama ka ho fokotsa ho tšoenyeha- [8] le boits'oaro bo kang boits'oaro [14]; e eketsa neurogeneis ea batho ba baholo ha a sebetsana le khatello ea monko oa makhopho [25] mme e khothaletsa liphetoho liphatlalatsong tsa lefutso ho dorsal le ventral striatum [5]. Ho latela liphetho tsa mosebetsi oa hona joale, keketseho ea kutloisiso ea lithethefatsi e ka eketsoa lenaneng la liphetoho tsa nako e telele tšebetsong ea boko tse hlahisoang ke boiphihlelo ba thobalano.
Ho bohlokoa ho supa hore lithethefatsi tse matla tse lemalloang ho litoeba tse amanang le thobalano ha li bapisoa le liphoofolo tsa thobalano li tlameha ho ba sephetho sa ketso e fapaneng ho feta ea ts'ebeliso ea hypersensitivity e hlokometsoeng ho litoeba tse felileng ka thobalano.. Sena se joalo, hobane se fetileng se sa amane le ts'ebetso ea thobalano ea morao-rao (likhoto tsena li bile le likamano tsa tsona tsa ho qetela tsa thobalano bonyane matsatsi a 5 pele ho ente ea 8-OH-DPAT), athe tsa morao-rao li bonahala li amana hantle le ho qopitsoa le boiphihlelo ba ho satiation (vide infra). Boikutlo bo khethollang ba 8-OH-DPAT ea liphoofolo tse nang le takatso ea ho kopanela liphate le batho ba ts'oanang le thobalano le bona bo ka lemohuoa liketsong tse tataisang tsa boitšoaro bona bo kopanetsoeng. Kahoo, ha 8-OH-DPAT e batla e haelloa ke phello ho likhoto tse nang le thobalano, e nolofalletsa litekanyetso tsohle tsa boitšoaro ba thobalano ka likhoto ka ho li fokotsa haholo, ka tekanyo e itseng, le ho eketsa haholo liperesente tsa liphoofolo tse khathetseng tse ileng tsa qalella ho kopitsa kamora ho emisoa. Leha bokhoni ba 8-OH-DPAT ho khutlisa satiation ea thobalano bo ne bo se bo thehiloe [18], mosebetsing ona hona joale phello e fumanoe e le litekanyetso tse tlase haholo ho feta tse neng li sebelisoa pele, e tiisa hypersensitivity ea likotsi tse satoang ka tsa thobalano liketsong tsa lithethefatsi. Le ha ho le joalo, ho lokela ho hopoloa hore maemo a thibelo ea thobalano ea litoeba tse nang le thobalano a ka be a bile le karolo ho holiseng litlamorao tsa 8-OH-DPAT ts'ebetsong. Litlamorao tse matlafatsang tsa thobalano tse nang le liteko tse bonoang li bonahala hantle ho liphoofolo tse sa sebetseng hantle thobalanong. Maemong afe kapa afe, ha ho hlahlojoa boitšoaro bo kopanetsoeng, ho ke ke ha khoneha ho khetholla pakeng tsa ketsahalo ea hypersensitivity phenomenon le phello ka lebaka la boemo bo ikhethileng ba boitšoaro ba thobalano.
Tlhahlobo ea nako ea hypersensitivity ho 8-OHDPAT joalo ka ha e lekantsoe ke polelo ea FBP e bonts'a hore ketsahalo ena e lula 72 h ho latela ts'ebetso ea satiation, mme e batla e nyamela 96 h kamora ho qopitsoa ha ho satiation. Ka lehlakoreng le leng, liketso tsa ho tsamaisa tsa 8-OH-DPAT mabapi le boits'oaro ba banna ba tepelletseng ka thobalano li ntse li le teng maemong ohle a ikhethang a boitšoaro ba thobalano 96 h kamora ts'ebetso ea ho satiation. Hape, monehelo oa boemo ba thibelo ea thobalano ho liketso tsa ts'ehetso tsa tekanyetso ena e tlase ea 8-OH-DPAT ka likhoto tse nang le thobalano li ke ke tsa hlakoloa. Ho fapana le moo, letšoao la FBP la lefu la 5-HT le ke ke la ferekanngoa le litlamorao tsa ts'ebetso ea satiation ka boeona mme ea hlaha, ka hona, e le karolo e ntle ea ho theha litšobotsi tsa ho hlaphoheloa ho tsoa ketsong ea hypersensitivity phenomenon.
Ts'ebetso ea ts'ebetso ea boipheliso e itlhahelang feela ea tšitiso ea boitšoaro ba thobalano e bakoang ke ho khathala ka thobalano le ea hypersensitivity ho 8-OH-DPAT, e lekiloeng ka polelo ea FBP, e senola hore liketsahalo tsena ka bobeli li latela nako e le 'ngoe. Ka hona, kamora 96 h ea phomolo ea thobalano, tšitiso ea thobalano e khutlisoa ho liphoofolo tsohle mme karolo ea likhoto tse satiated e bonts'a FBP e oela ho 25%, ho fapana le hoo e batlang e le 100% ea bona e bonts'ang letšoao lena la lefu la 5-HT nakong ea 72 h ea pele. latela satiation. Nako ena ea ho hlaphoheloa e bontša hore liketsahalo tsena tse peli li ka emela lipontšo tse fapaneng tsa tšebetso e tšoanang ea bokhabane ba boko. Taba ea hore hypersensitivity ea litoeba tse felileng ka thobalano e nyamela matsatsi a 4 kamora boiphihlelo ba ho qetela ba thobalano e ts'ehetsa hape mohopolo oa hore mochini o ka tlase o tlameha ho fapana le o hlahisang hypersensitivity ho litoeba tse nang le thobalano, tse neng li ntse li le teng matsatsing a 5 kamora ho ba le thobalano ea bona ea ho kopanela liphate. Pitchers et al. Haufinyane tjena ho tlalehiloe hore boiphihlelo ba thobalano bo etsa hore motho a be le boits'oaro ho litoeba tsa banna, moo litoeba tse nang le thobalano li bonts'ang karabelo e eketsehang ea locomotor ho amphetamine ha e bapisoa le liphoofolo tsa thobalano tsa naïve [15]. Ho ts'oana ha mokhoa ona oa ho fumana le data e teng hona joale hoa bonahala, hobane boits'oaro bo botle bo fana ka karabelo e eketsehang ea karabelo / hypersensitivity ho lithethefatsi tsa tlhekefetso. Tumellanong le datha ea hajoale ea liphoofolo tse nang le thobalano, ntho e tlalehiloeng e khothatsang e tlalehiloe kamora ho khahlisoa khafetsa; mokhoa o khahlisang ho ea sebelisoang mosebetsing oa hona joale ho fana ka likhoto tse amanang le thobalano, le beke ka mor'a karolo ea ho qetela ea ho tlolelana; latency e bapisoang le nako ea matsatsi ea 5 e lumelletsoeng pele ho liteko tsa lefu la 5-HT mosebetsing oa rona.
Ho khahlisang, li-Pitchers le basebetsi-mmoho le bona ba ile ba leka phello ea khafetsa khafetsa matsatsing a 7 a latellanang ho ketsahalo ea amphetamine-induction locomotor sensitization phenomenon mme ha baa ka ba fumana phapang ka karabelo e fumanoeng kamora ho hlekefetsoa ha nako ea mating [15]. Phapang ena ea data le hypersensitivity e boletsoeng le e khuts'oanyane ho 8-OH-DPAT e tlalehiloeng bakeng sa likhoto tse felisitsoeng ka thobalano ha e bapisoa le liphoofolo tse nang le bohlola. Phapang ena e kanna ea itšetleha ka taba ea hore paradigm e feteletseng ea ho ts'oaroa ka thobalano (7 ka karolelano) e etsahala ka nako e khuts'oane haholo (ho pota 2.5 h) mme ka hona e ka baka ts'ebetso e fapaneng ho feta e hlahisoang ke kemolo e le 'ngoe ka letsatsi ho 7 matsatsi a latellanang. Phapang e kholo sephethong sa tsena tse peli tsa paradigms e bonoa nakong ea ketsahalo ea hypersensitivity, e ileng ea nka matsatsi a 3 feela ho likhoto tse felisitsoeng ka thobalano mme e bolokiloe bonyane matsatsi a 28 litekong tse kenyellelitsoeng matsatsing a 7 ka ho latellana ho Pitchers sebetsa.
Ka bobeli, tlhaiso-leseling e hlahisitsoeng mona e bonts'a hore ts'ebetso ea kopulate ka kakaretso e ama ts'ebetso ea boko ba likhoto tsa banna, ka ho fetola monyako oa liketso tsa lithethefatsi. Phallo ho satiation, haholo, e hohela ketsahalo ea hypersensitivity le boemo ba thobalano le ho bonahala eka bo latela nako e tšoanang ea ho hlaphoheloa, ho bonts'a ho fokotseha ho hoholo ha 96 h kamora ho satiation ea thobalano. Sebopeho se tšoarellang sa liketsahalo tsena ka bobeli se ka hlalosoa feela ke ketsahalo ea liphetoho tsa polasetiki ea boko tseo, ka ho khahlisang, li nyamelang butle butle ka nako ho paka sebopeho se fetohang. Ho ka nahanoa hore tšitiso ea nako e telele ea thobalano e bakiloeng ke ho kopitsoa ha satiation ke mokhoa o itšireletsang khahlanong le ho tsosa lirafshoa tsa boko tse amehang ts'ebetsong ea tsona. Sisteme ea mesolimbic e bapala karolo ea ts'ebetsong ea meputso ea tlhaho ho kenyelletsa boitšoaro ba thobalano [2]. Ho susumetsa khafetsa ha potoloho ena ka taolo e sa khaotseng ea lithethefatsi tsa tlhekefetso ho hlahisa maikutlo a boits'oaro [16] e tšoanang le lithethefatsi tse matla tse bonts'itsoeng ke litoeba tse felileng ka thobalano kamora ho ts'oaroa khafetsa ka nako e khuts'oane, e neng e tla tsosa ts'ebetso ea mesolimbic kamehla [2].
Likhopolo tse kopanetsoeng tsa nakoana tsa lithethefatsi hypersensitivity le thobalano ea thobalano e tlalehiloeng mona li ka hlalosoa e le bopaki ba ho ba teng ha bona tsamaisong ea mesolimbic. Liketsahalo tsena ka bobeli e ka ba mantsoe a fapaneng a ketsahalo e tloaelehileng, ea nakoana le ea bongoana e etselitsoeng ho sireletsa ts'ebetso ea mesolimbic ho tsoa ho tsusumetso e fetisisang nakong ea ho kopitsa ho fihlela mokhathala.
Liteko tsa nako e tlang li lokela ho tsamaisoa ho ithuta mekhoa e ka kenyelletsang ts'ebetso e khahlisang joalo: ho kenyelletsa liphetoho tse telele tsa ts'ebetso ea boko tse shebahalang li ka fetoha.
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