Ntlha ea corticotropin-e lokollang nucleus accumbens shell e etsa hore ho sesa ho tepella maikutlong, matšoenyeho le anhedonia hammoho le liphetoho tsa tekanyo ea dopamine / acetylcholine (2012)

Khopolo-taba. 2012 Mar 29; 206: 155-66. Doi: 10.1016 / j.neuroscience.2011.12.009. Epub 2012 Jan 5.

Chen YW1, Rada PV, Bützler BP, Leibowitz SF, Hoebel BG.

inahaneloang

Nucleus accumbens shell (NAcS) e kentsoe letsoho ho laoleng likarabo tsa khatello ea maikutlo ka corticotropin-releasing factor (CRF). Ntle le liphuputso tse bonts'ang hore CRF ho NAcS e eketsa tšusumetso ea takatso ea maikutlo, ho na le bopaki bo sa tobang bo bonts'ang hore NAcS CRF e kanna ea baka likarabo tse fapakaneng le hore boits'oaro bona bo ka buelloa ka lits'ebetso tsa lehae tsa dopamine (DA) le acetylcholine (ACh). Ho fana ka teko e tobileng ea khopolo-taba ena, re sebelisitse likhoto tsa banna tsa Sprague-Dawley tse nang le li-cannulas tse kentsoeng ho NAcS. Teko ea 1 e bontšitse ente ea CRF ea lehae (10 kapa 50 ng / lehlakoreng) ho eketsa ho se sisinyehe tekong ea ho sesa e qobelloang le mohanyetsi oa CRF D-Phe-CRF ((12-41)) ho fokotsa boits'oaro bo joalo bo sithabetsang. Teko ea 2, ente ea CRF (250 ng / lehlakoreng) le eona e fokolitse khetho ea likhoto bakeng sa sucrose, ha e ntse e le Teko ea 3, CRF (50 kapa 250 ng / lehlakoreng) e hlohlellelitse boits'oaro bo ts'oanang le matšoenyeho sebakeng se phahameng le se bulehileng. Tekanyo e tšoanang ea CRF ho Teko ea 4 e hlotsoe ho fetola ts'ebetso ea litoeba, ho bontša hore liphetoho tsena tsa boits'oaro ha li bakoe ke khaello ea ts'ebetso. Teko ea 5, liphetho tse tsoang ho vivo microdialysis li senotse hore CRF ho NAcS e ekelitse haholo AC ea kantle ho sele, ha e ntse e hlahisa keketseho e nyane ho DA. Liphetho tsena li bonts'a hore NAcS CRF e ka hlahisa boits'oaro bo fapaneng, ho kenyelletsa khatello ea maikutlo a ho sesa, anhedonia le matšoenyeho, ho kenyelletsa boitšoaro ba haufi. Ba fana ka maikutlo a hore boits'oaro bona bo ka hlaha, ka karolo e 'ngoe, ka ts'ebetso e ntlafalitsoeng ea ACh le DA ho NAcS, ka ho latellana, e ts'ehetsa karolo ea sebaka sena sa boko ho loantšeng litlamorao tse peli tsa khatello ea maikutlo.