(L) Bo-rasaense ba fumana hore na hobaneng boikoetliso bo fokotsa khatello ea maikutlo: Galanin & neuroplasticity (2015)

Ka holim'a mabaka a mangata a ho otla ho ikoetlisa, ho sebetsa ho ka boela ha ntlafatsa matla a ho mamella ka linako tse thata. Letotong la liteko tse sa tsoa etsahala, litsebi tsa kelello Univesithi ea Georgia li qalile ho senya kamano pakeng tsa nako e telele ea ho imeloa kelellong le ho ikoetlisa.

Thuto, e hatisitsoeng khatisong ea February ea koranta Neuropharmacology, e senola hore neuropeptide e bitsoang galanin ke karolo ea bohlokoa ea selotho. Bafuputsi ba bontšitse ka mohlala oa liphoofolo hore galanin e sireletsa li-neuron ho senyeheng ho bakoang ke khatello ea maikutlo. Ha likhoto li ikoetlisa, 'me galanin e koetsoe, likhoto li ne li tšoenyehile joalo ka ha eka ha li a ikoetlisa ho hang. Bafuputsi ba boetse ba bontšitse hore galanin e khutlisa litlamorao tse mpe tsa khatello ea maikutlo har'a likhoto tse lutseng. Bopaki ba anatomiki bo fana ka maikutlo a hore galanin e kenya letsoho ho imolla khatello ea maikutlo ka ho boloka polasetiki ea synaptic, kapa tsela eo likhokelo tsa neural li matlafatsoang kapa ho fokola ha nako e ntse e tsamaea.

"Re ile ra khona ho bontša hore khatello ea maikutlo, ho pepesehela khatello ea maikutlo hanngoe feela, ho bakile ho fokotseha ha sebopeho sa synapse," ho boletse Philip Holmes, mofuputsi ea ka sehloohong oa thuto le moprofesa oa thuto ea kelello ho Franklin College of Arts and Sciences. Holmes hape e le molulasetulo oa Lenaneo la Neuroscience la Setsi sa Biomedical le Health Science Institute. “Khopolo-taba e ne e le hore mohlomong seo galanin e se etsang, le seo boikoetliso bo se etsang, ke ho boloka methapo ea pelo e le teng prefrontal cortex. "

Prefrontal cortex e ikarabella bakeng sa boits'oaro bo rarahaneng ba tsebo, ho etsa liqeto, taolo ea maikutlo le khatello ea maikutlo. Hoa thahasellisa hore ebe Holmes, sebaka sena sa boko ba likobo nakong ea ho tepella maikutlong, o itse. Ho lekanya sebopeho sa synapseLaboratori ea Holmes e baliloe dintritic spines ka li-neurone tse karolong e ka pele ea cortex. Haeba li-dendrites ke makala a neuron, joale likarolo tsena tsa subcellular ke makala ho makala ao.

Natale Sciolino, mongoli oa pele oa pampiri eo o re: "Metsoana ea dendritic e fetoha haholo ka boiphihlelo." Ho bala mokokotlo oa dendritic spines ho thusitse Sciolino ho sheba seo a reng ke "motheo oa bohlokoa oa anatomiki oa polasetiki, kapa bokhoni ba boko ba ho fetoha."

Sciolino o ne a qetile Ph.D. oa hae. nakong ea teko 'me hona joale e se e le setho se seng sa basebetsi setsing sa National Institute of Environmental Health Sciences. Ha Sciolino e fumana mefuta e fokolang ea likhohlopo ho likhoto tsa sedentary ho feta tse sebelisitsoeng kapa tse fuoang letšoao la galanin, o ne a tseba hore laboraka e fumane ntho e bohlokoa.

Sehlopha se ne se sebelisa litšitiso tsa maoto a mabeli le boima bo bōpehileng joaloka boiteko ba ho lekanya boitšoaro bo tšoenyang maqeba. Litoeba tse imetsoeng tse ileng tsa sebelisa kapa tsa amohela galanin li ne li ikemiselitse ho hlahloba maze, e leng pontšo ea ho tiea. Leha ho le joalo, litoeba tse tsitsitseng li ne li sa batle ho hlahloba. Phuputsong e 'ngoe, bafuputsi ba ile ba fa likhoto tse sebelisang lithethefatsi ho thibela ketso ea galanin,' me litoeba li ile tsa lula li behiloe khafetsa joaloka sehlopha sa bolulo.

"Re fumane tšireletso ena ea boikoetliso, empa re ka e thibela le mohanyetsi oa galanin, kahoo seo se ne se hlile se thabisa hobane seo se re joetse hore galanin e hlokahala molemong oa boikoetliso," ho boletse Holmes. Ka sebele ke eona teko ea bohlokoa. ”

Holmes le Sciolino ba thehile kamano e ntle lipakeng tsa boikoetliso le ho imeloa kelellong liphuputsong tse fetileng ho UGA. Pampiri ea bona ea 2012 e bontšitse hore boikoetliso bo eketsa karolo ea galanin sebakeng se ka sehloohong sa boko se sebetsanang le khatello ea kelello. Thuto ea morao-rao e ikemiselitse ho kopanya liphuputso tsena ho latela mohlala o le mong o hlalositsoeng hantle.

"Re tseba ka ho eketsehileng hore bopaki bo supa mofuta o itseng oa khaello ea methapo ea pelo e le ts'ebetso ea bohlokoahali mathateng a amanang le khatello ea maikutlo joalo ka khatello ea maikutlo le ho tšoenyeha," ho boletse Holmes.

Sciolino o ile a qala ho etsa lipatlisiso mabapi le kamano pakeng tsa boikoetliso ba 'mele le galanin ka mor'a Holmes le David Weinshenker, moprofesa oa liphatsa tsa lefutso Univesithing ea Emory, ba fumane thuso ho Mokhatlo oa Sechaba oa Tlhekefetso ea Meriana bakeng sa lipatlisiso tsa lithethefatsi 2010.

“Rea tseba hore khatello ea maikutlo ke sesosa se atileng ka ho fetesisa ho batho ba nang le ts'ebeliso ea lithethefatsi, mme re khonne ho bonts'a hore boikoetliso kapa galanin e fokotse boitšoaro bo tšoanang le ba likhoto tse fuoeng cocaine, ka hona bokhoni ba ho ikoetlisa bo susumelletsang galanin ho fokotsa khatello ea maikutlo hoa utloahala, ”ho boletse Weinshenker.

Sciolino o re setšoantšo se seholo sa lipatlisiso tsena ke hore re ka sebelisa molemo oa boikoetliso hobane re utloisisa mochini. Lefapha la methapo ea kutlo le qalile ho ananela boholo ba phello ea galanin bokong.

"Ke rona feela laboratori e shebileng khokahano e teng lipakeng tsa galanin le boikoetliso," ho boletse Holmes. Ho hotle ebile ho hobe - ho hotle hore ebe re na le niche ea rona e nyane, empa ho hobe hobane e sa fumane tlhokomelo e lekaneng.

Hlahloba ho eketsehileng: Thuto e fana ka maikutlo a batho ba nang le galanin ba fokolang khatello ea kelello

Boitsebiso bo eketsehileng: "Galanin e buella likarolo tsa khatello ea kelello le boits'oaro tse fanoang ke boikoetliso." Neuropharmacology. 2015 Feb; 89: 255-64. DOI: 10.1016 / j.neuropharm.2014.09.029. Epub 2014 Oct 6.

Lintlha tsa boitsebiso: Neuropharmacology

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