Bopaki bo ka pele ho tlhaho bo amanang le corticotropin-ho lokolla ho bonts'oa ha motsoako oa ethanol le ho sebelisoa ha motlakase (2015)

Liphetho tsa lithuto tse ngata li tšehetsa tšusumetso ea corticotropin-releasing factor (CRF) ts'ebelisong ea ethanol (EtOH) le li-neuroadaptations tsa EtOH tse bohlokoa ts'ebetsong ea bokhoba. Tlhahlobo ena e akaretsa lintlha tsa tlhaiso-leseling sebakeng sena kamora ho fana ka kakaretso ea likarolo tsa tsamaiso ea CRF. Sistimi ena e rarahaneng e kenyelletsa mekhoa ea hypothalamic le extra-hypothalamic tse sebelisang karolo ea mantlha le litlamorao tsa khatello ea maikutlo, ho kenyelletsa EtOH le lithethefatsi tse ling tsa tlhekefetso. Ntle le moo, li-ligands tse 'maloa tsa sepheo sa' mele le sepheo li etsa ts'ebetso ena mme li bonts'a ho se amehe ha bona ho noeng EtOH le litlamorao tsa kalafo ea kamehla ea EtOH. Ka kakaretso, mekhoa ea liphatsa tsa lefutso le ea meriana e fana ka setšoantšo se lumellanang sa bohlokoa ba CRF ho saena ka mofuta oa 1 CRF receptors (CRF1) ho li-neuroadaptations tse hlahisoang ke EtOH tse hlahisang litekanyo tse phahameng tsa khothalletso, ho khothaletsa ho ts'oara joala nakong ea ts'ebeliso le maikutlo a fetohang a maikutlo a EtOH. Ntle le moo, lipatlisiso tsa liphatsa tsa lefutso literekeng, litloholo tsa batho bao eseng batho le batho li fane ka bopaki bo bong ba ho amahanngoa le liphatsa tsa lefutso ho liphatsa tsa lefutso tse amanang le CRF le joala ba EtOH, leha ho hlokahala lintlha tse ling. Liphetho tsena li fana ka maikutlo a hore bahanyetsi ba CRF1 ba na le menyetla ea ho ba litlhare tsa litlokotsi tsa tšebeliso ea joala. Leha ho le joalo, ka lebaka la karolo e pharaletseng le ea bohlokoa ea li-receptor tsena ho ikamahanya le liphephetso tsa tikoloho le tse ling, litlamorao tse matla tsa ho hanyetsa li ka ba matla haholo mme ho lokela ho fuoe kalafo e nang le litlamorao tsa phetoho.