Maikutlo: Lebaka le letle la ho phomola. Boithuto bo bong bo bontšitse hore ho haella ha boroko ho lebisa ho ho ja ho tlōla, ho ka amanang le li-receptor tse tlase tsa dopamine D2.
Bopaki ba hore Boroko bo Ts'oants'oa Phallo ea Dopamine D2R ho Ventral Striatum ho Boko ba Motho.
J Neurosci. 2012 May 9; 32 (19): 6711-7.
Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Logan J, Benveniste H, Kim R, Thanos PK, Ferré S.
inahaneloang
Li-receptor tsa Dopamine D2 li ameha ka ho tsoha, empa karolo ea bona ho foleng ho falimeha e amanang le ho hloka boroko ha e hlake. Re ne re bontšitse hore ho hloka boroko ho fokolitse phumaneho ea receptor ea dopamine D2 / D3 (e lekantsoeng le PET le [(11) C] raclopride in control) ho striatum, empa e sitoa ho tseba hore na ena e bonts'a dopamine e eketseha ([(11) C] raclopride e qothisana lehlokoa le dopamine bakeng sa tlamo ea receptor ea D2 / D3) kapa phokotso ea taolo. Ho hlakisa sena, re bapisitse keketseho ea dopamine e bakoang ke methylphenidate (sethethefatsi se eketsang dopamine ka ho thibela ba tsamaisang dopamine) nakong ea boroko le boroko bo phomotseng, ka mohopolo oa hore litlamorao tsa methylphenidate li ka ba kholo haeba, kannete, tokollo ea dopamine e eketsehile nakong ea boroko ba boroko . Re ile ra sekaseka litsamaiso tse 20 ka [(11) C] raclopride kamora ho phomola boroko le kamora bosiu bo le bong ba boroko; ka bobeli kamora placebo le kamora methylphenidate. Re hlophisitse ho fokotseha ha phihlello ea D2 / D3 receptor kahare ea "ventral striatum" le ho hloka boroko (ho bapisoa le boroko bo khutsitseng) bo neng bo amahanngoa le ho falimeha le ho eketsa boroko. Leha ho le joalo, dopamine e eketseha e susumetsoang ke methylphenidate (e lekantsoeng ha e fokotseha ho fumaneha ha li-receptor tsa D2 / D3 ha e bapisoa le placebo) ha ea fapana pakeng tsa ho phomola ha boroko le ho hloka boroko, mme e ne e amahanngoa le ho falimeha ho eketsehileng le ho fokotsa ho robala ha methylphenidate ha ho fanoa ka mor'a ho hloka boroko. Liphumano tse ts'oanang li fumanoe ka microdialysis litonong tse tlatselitsoeng ho 1 bosiu ba ho hloka boroko ka mokhoa o makatsang. Liphumano tsena li tsamaellana le ho theoha ha li-receptor tsa D2 / D3 ho li-ventral striatum ka lebaka la ho hloka boroko tse ka bakang ho eketseha hoa ts'ebetso e amanang le ho fokotseha hape ho tiisa ho eketsoa ha li-receptor tsa D2 ho litlamorao tse tsosang tsa methylphenidate ho batho.
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