Litholoana tsa dopamine li hlaka haholo ha boko bo fumana bo fokolang haholo, joalo ka lefu la Parkinson. Ho se leka-lekane ha dopamine ho lebisa ho litšitiso tse fapaneng tsa methapo - haholo-holo ho sisinyeha - empa le bokhoni ba kelello. Setsi sa rona sa mantlha sa kutloisiso, cortex ea pele, eo re e sebelisang ho nahana ka mokhoa o hlakileng, liqeto tse thehiloeng melao le liqeto tse utloahalang, e fanoa ka matla ka dopamine. Leha e le bohlokoa ba bongaka, ha re tsebe hakaalo ka litlamorao tsa dopamine ts'ebetsong ea tlhaiso-leseling ke li-neuron bokong bo phetseng hantle.
Ho leka sena, bafuputsi ba koetlisitse litšoene tsa rhesus ho rarolla "kholo ho feta" le "tlase ho" mathata a lipalo. Ho tsoa lipatlisisong tse ling tsa morao-rao, bafuputsi ba ne ba tseba hore li-neuron tse ling tse karolong e ka pele ea cortex li araba lipotso tse joalo - halofo ea "lisele tsa puso" ena e ne e ts'oaroa feela ha ho sebelisoa molao "o moholo ho", 'me halofo e' ngoe e sebelisoa feela ha "tlase" ho feta ”molao o sebelisitsoeng.
Khabareng, lintho tse fokolang tsa 'mele li ne li romelloa haufi le lisele tse amehang. Lintho tsena li ka ba le phello e ts'oanang le ea dopamine - kapa phello e fapaneng - mme li ka phatlalatsoa ke li-neurop tsa kutlo tsa dopamine. Sephetho se makatsang ke hore tsamaiso ea dopamine e lumelletse "lisele tsa taolo" hore li sebetse hantle le ho khetholla ka ho hlaka lipakeng tsa melao e "kholo ho feta" le "tlase ho". Dopamine e bile le phello e ntle ho boleng ba mosebetsi oa "lisele tsa taolo".
Phuputso e fana ka leseli le lecha mabapi le hore na dopamine e susumetsa mekhoa e sa bonahaleng ea ho nahana e hlokahalang, ho etsa mohlala, ho sebelisa melao e bonolo ea lipalo. Ott o re: "Ka liphuputso tsena, re ntse re qala ho utloisisa hore na lisele tsa methapo ea pelo ea" cortex "li hlahisa boits'oaro bo rarahaneng, bo tataisoang ke sepheo. Hammoho le kutloisiso e betere ea metheo ea tlhahiso ea tlhahisoleseding karolong ena ea bohlokoa ea boko, liphetho li ka ba le bohlokoa ba bongaka. Moprofesa Nieder o re: "Litemoso tsena tse ncha li re thusa ho utloisisa hamolemo litlamorao tsa meriana e meng e ka sebelisoang maemong a ho ba le pherekano e kholo ea kelello," hobane meriana e joalo e susumetsa dopamine lekaleng ka har'a prefrontal cortex ka litsela tseo re sa li utloisiseng hantle ho fihlela joale. ”
Hlahloba ho eketsehileng: Bafuputsi ba fumana tahi ea epigenetic ho mafu a neuropsychiatric
Boitsebiso bo eketsehileng: Torben Ott, Simon N. Jacob, le Andreas Nieder: "Baamoheli ba Dopamine ka mokhoa o fapaneng ba Ntlafatsa Molao oa Kh'outu ho Primate Prefrontal Cortex Neurons." Neuron, Khatiso e Qalang ea Marang-rang, 4 Dec. 2014. DOI: 10.1016 / j.neuron.2014.11.012
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