J Neurosci. 2014 Apr 2;34(14):5012-22. doi: 10.1523/JNEUROSCI.3707-13.2014.
Furlong TM1, Jayaweera HK, Balleine BW, ICorbit LH.
abstract
Ukutholakala kokudla okunambitheka kakhulu futhi okuminyene nekhalori kunomthelela ekukhuleni kwamazinga okukhuluphala emhlabeni jikelele. Abanye benze impikiswano ephikisanayo yokuthi ukusetshenziswa kwalokhu kudla kungaholela "ekuluthweni kokudla," kepha kuncane okwaziwayo ukuthi ukufinyelela isikhathi eside kokudla okunomsoco kungakuguqula kanjani ukufunda okuqondiswe imigomo nokwenza izinqumo.
Kokuhlolwa okulandelayo, amagundane anikezwa amasonto ama-5 wokufinyelela okuqhubekayo noma okuvinjelwe nsuku zonke ebisini oluncibilikisiwe (SCM) ngaphambi kokuqeqeshwa kokuxhaswa ngomvuzo wokudla. Ngemuva kwalokho sahlola ukuthi ngabe ukusebenza okuqondiswe izinhloso kuchaphazelekile kulawa maqembu kusetshenziswa umsebenzi wokudonswa phansi imiphumela. Amagundane okulawula anciphise ukuphendula ngemuva kokudonswa phambili kwemiphumela etholakele njengoba kwenzeka kulabo abathola ngokuqhubekayo be-SCM. Okuthakazelayo, amagundane anokufinyelela okukhawulelwe kokuqala kwe-SCM kuphendulile okufanayo ngaphansi kwezimo ezibucayi nezingathandeki, okubonisa ukulahleka kokulawulwa okuqondiswe kunhloso kokuphendula. Ukubona ukuthi ngabe ukulahleka kokulawulwa okuqondiswe emgomeni kuhambisana nokuhluka komsebenzi we-neuronal, sisebenzise i-c-Fos immunohistochemistry ukuhlola amaphethini wokusebenzisa ngesikhathi sokuhlolwa kwe-devaluation. Siphawule ukukhuluphala kwe-c-Fos enkulu ku-dorsolateral striatum (DLS) kanye nezifunda ezihlobene ne-cortical eqenjini elithole ukufinyelela okukhawulelwe kokufinyelela ku-SCM futhi sakhombisa ukungazweli kokuphumela kokudonswa kwemali phansi. Ukufakwa kwe-AMPA-receptor antagonist CNQX noma i-dopamine D1-receptor antagonist SCH-23390 kwi-DLS ngaphambi kokuhlola ukusebenza okuqondiswe kumgomo eqenjini elivinjelwe i-SCM, okuqinisekisa ukuthi lesi sifunda sibalulekile ekusebenzeni okwenziwa umkhuba. Le miphumela ikhombisa ukuthi ukudla okudlulile kungashintsha ukufunda okwenziwe nokulandelayo kumasekethe we-neural asekela ukusebenza.