I-Am J Physiol Regulolid Comp Physiol. 2003 May;284(5):R1260-8.
Bello NT1, I-Sweigart KL, Lakoski JM, INorgren R, Hajnal A.
abstract
Ucwaningo lwakamuva luveza ukuthi uhlelo lwe-dopamine lwe-mesoaccumbens lubhekana nokuguqulwa kwezinzwa ngenxa yezimo ezinqunyelwe zokuphakelwa kokufinyelela ushukela. Lo mphumela ubonakala ufana neuroadaptation ebangelwa izidakamizwa zokuhlukumeza futhi ingagcina izimilo ezithile zokudla kokuphilayo.
Ukuqhubeka nokuhlolisisa izindlela zamaselula kwalokhu kuguqulwa, ucwaningo olukhona lusebenzise ubungako be-autoradiography kanye ne-hybridization ukuhlola i-dopamine membrane transporter (i-DAT) ubungqabavu bamaprotheni kanye nencazelo ye-mRNA ekuvinjelweni kwabesilisa nabadala kwamahhala. Uhlobo lokuvinjelwa olukhawulelwe lwaluqukethe ukufinyelela okukhawulelwe kwansuku zonke kwekhambi le-sucrose evame ukuthandwa (i-0.3 M) noma i-chow encanyelwayo engafakwanga ngendlela ehleliwe (ie, impingent) yemfashini yezinsuku ze-7. Amagundane avinjelwe okwenqunyelwe ngokufinyelela okuhambisanayo we-sucrose alahlekelwe isisindo somzimba esincane, adla ukudla okuphelele, futhi aphuza uketshezi oluningi kunokudla okuphekiwe kwamahhala, ukudla okuphikisanayo, noma izilawuli ezingavikeleki. Ngaphezu kwalokho, lezi zilwane zazinokuzikhethela okuphezulu kokuzibopha kwe-DAT endaweni eyi-nucleus accumbens nendawo ye-ventral tegmental. Lokhu kukhula kokubopha kwamaprotheni nakho kuhambisane nokwanda kwamazinga e-DAT mRNA endaweni ye-ventral tegmental. Ngokungafani namaqembu anqunyelwe-okunikezwe amandla, awukho umphumela ohlukile kumthethonqubo we-DAT obonwe kuwo wonke amaqembu atholakala mahhala.
Ukushintshwa okubonakalayo kokuziphatha kanye nomthethonqubo we-DAT kusikisela ukuthi i-neuroadaptation ohlelweni lwe-dopamine ye-mesoaccumbens ikhula ngokuphendula okuphindaphindwe kokudla okuthandekayo ngaphansi kwezinkinga zokudla. Lokhu kusekela umbono wokuthi izinguquko ezifanayo zamaselula zingabandakanyeka ekuphazamisekeni kokudla okuvinjelwe kanye ne-bingeing.
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