I-Prog Neuropsychopharmacol Biol Psychiatry. I-2008 Apr 1; 32 (3): 620-8. doi: 10.1016 / j.pnpbp.2007.09.024.
UDavis C1, I-Levitan RD, Kaplan AS, UCarter J, Reid C, UCurtis C, Patte K, Hwang R, I-Kennedy JL.
abstract
INJONGO:
Ukuzwela kwezindlela zokuthola umvuzo we-dopamine kuye kwafakwa engcupheni yokuphazamiseka kwengqondo okuhlukahlukene kufaka phakathi ukudla ngokweqile okuphoqayo. Ubufakazi buhlukaniswe, noma kunjalo, mayelana nokuqondiswa kokuhlangana kwenhlangano. Enye impikiswano ukuthi i-Reward Deficiency Syndrome iyona nto ebeka engcupheni, kanti abanye baphikisana nokuthi izinzwa ze-hyper sensivivity zithuthukisa isisusa semisebenzi emnandi njengokudla. Ngeshwa, ucwaningo oluncane lwabantu luvimbe igebe phakathi kwezindlela ezingokwengqondo nezokusebenza kwengqondo zokuthola umvuzo wokusebenza kwengqondo nokuphazamiseka kwengqondo. Ucwaningo olukhona lubhekane nalolu daba ngokusebenzisa izimpawu zomqondo nezemvelo zokuzwela ngomvuzo kuphrothokholi yokuhlola.
IZINDLELA:
Abantu abadala abanenkinga yokudla okune-binge (BED) babeqhathaniswa namasampula wokulawulwa kwesisindo esijwayelekile nokukhuluphala kuzinto ezimbili zobuntu bokuzwa kwemivuzo futhi bahlelwa izakhi eziyisithupha ze-DRD2 dopamine receptor gene.
IZIPHUMA:
IGenotype x Iqembu lama-ANOVA liveze imiphumela ephambili ebalulekile kanye nokuxhumana ngezinyathelo zobuntu zeTaq1A. Izifundo ze-BED nezikhuluphele zibike ukuzwela okukhulu komvuzo kunezilawuli ezijwayelekile zesisindo, kepha phakathi kwalabo abaphethe i-A1 allele. Siphinde sathola ukuthi izilawuli ezijwayelekile zesisindo ezinekhophi okungenani eyodwa ye-T allele ye-C957T umaki yayinezimpawu eziphansi zokuzwela umvuzo kunanoma yiliphi elinye iqembu elalingafani nelinye.
IMIBUZO:
Kunikezwe ubufakazi obuxhumanisa i-A1 allele ne-receptor density encishisiwe, ubudlelwane obungenakulindelekile babulindelwe phakathi kwezinyathelo zengqondo zokuzwa komvuzo kanye nokuba khona kwe-A1 allele. Enye incazelo yokuthola kwethu kungenzeka ukuthi abahlanganyeli be-BED kanye nama-onese banokunye okuhlukahluka kofuzo okuxhumana ne-A1 allele ukukhiqiza umsebenzi ophakeme we-dopamine. Lokhu okutholakele kunemiphumela yocwaningo lwesikhathi esizayo lwe-genetics yamangqamuzana e-BED kanye nokukhuluphala, kanye nezindlela zokuziphatha nezokwelapha eziqondiswe kulezi zimo.
I-PMID: 18262320
I-DOI: 10.1016 / j.pnpbp.2007.09.024