I-Med Prev. I-2016 Aug 7. pii: S0091-7435 (16) 30215-8. I-Doi: 10.1016 / j.ypmed.2016.08.009.
abstract
Kokubili ukubhema ugwayi kanye nokukhuluphala kuyinkinga enkulu yezempilo yomphakathi futhi kuhlobene nengozi enkulu yokufa kwabantu kusenesikhathi. Kusungulwe kahle ukuthi indlela ye-mesolimbic dopamine indlela eyingxenye yohlelo lomvuzo ngaphakathi kwengqondo futhi ifaka isandla ekuthuthukiseni umlutha. Impela, i-nicotine nokudla okuthambekele kakhulu kuyakwazi ukuguqula ukukhishwa kwe-dopamine kulolu hlelo, ukulethe izimpendulo eziluthayo njengabantu abangenayo. Yize kucwaningwe okwengeziwe, kufanelekile, okutholakele ezincwadini nasezincwadini zabantu kuye kwacacisa ama-neuroadaption amaningi avela ekuchayweni kokudla nicotine nokudla okuthe xaxa, okuholela ekuqondeni okukhulu kwezindlela ezikhona ezifake isandla kulokhu kuziphatha okungahambi kahle. Kulesi sibuyekezo sethula okutholakele okuvela ezincwadini ezithathwa njengamakhompiyutha nezomtholampilo ngemiphumela eyaziwayo yokuchayeka ku-nicotine nokudla okutholakala kalula kakhulu kumjikelezo ohlobene nokusebenza kwengqondo. Ngaphezu kwalokho, siqhathanisa ukunqwabelana kwemizwa nokuziphatha phakathi kwe-nicotine, ukudla okuthandekayo nokukhuluphala. Okokugcina, sibheka ukubhekabheka okuhambisana nokubhema, ukukhuluphala ngokweqile kanye nokulutha kokudla, kanye nemiphumela yokubandlululwa okunakho empilweni yonke kanye nasenhlalakahleni yomuntu.
KEYWORDS: Dopamine; Umlutha wokudla; Ukudla okuthandekayo; UNicotine; Ukukhuluphala
I-PMID: 27509870
I-DOI: I-10.1016 / j.ypmed.2016.08.009