I-Neuropsychopharmacology 17 Meyi 2017;
doi: 10.1038 / npp.2017.78
Mateusz Gola1,2, Małgorzata Wordecha2, UGuillaume Sescousse3, Michał Lew-Starowicz4, UBartosz Kossowski5, UMarek Wypych5, UScott Makeig1, UMarc N Potenza6,7,8 no-Artur Marchewka5
Ukubhalelana: UDkt M Gola, iSwartz Center for Computational Neuroscience, Institute for Neural Computations, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093-0559, USA, Tel: 858 500 2554 / 858 822, E-mail : [i-imeyili ivikelwe]
Ukubuka kuqala kwendatshana eyamukelwe online ku-14 Ephreli 2017; Phambi kokushicilelwa online ku-17 Meyi 2017
abstract
Ukusetshenziswa kwezithombe zobulili ezingcolile kuvame kakhulu, ikakhulukazi kubantu besilisa abadala. Kwabanye abantu, ukusetshenziswa kwezinkinga zocansi okuyinkinga (i-PPU) yisizathu sokufuna ukwelashwa. Naphezu kokuxhaphaka kwezithombe zocansi, i-PPU ibonakala ingaphenywa, kufaka phakathi izindlela ezingaphansi ze-neural. Sisebenzisa i-imaging resonance imaging (i-fMRI) esebenzayo, sihlola izimpendulo ezixakile nezisusa imali, sahlukanisa 'ukufuna' okuhlobene nokukhokhelwa okuhlobene nomvuzo phakathi kwabesilisa abesilisa nabesilisa abalingani be-28 abafuna ukwelashwa nge-PPU ne-24 abesilisa nabobulili obuhlukile ngaphandle kwe-PPU. Izinto ezibandakanyeke emsebenzini wokulibaziseka wokukhuthazeka eskena, lapho zithole khona imivuzo evusa inkanuko noma yemali eyandulelwa yizinkomba zokuqagela. Izimpendulo ezisekelwe egazini ezikhipha komoya-mpilo ezinhlakeni ezingekho emthethweni zahlaziywa futhi zahlolwa maqondana nemininingwane yokuzazisa ngezinto eziphathelene nezocansi eziqoqwe ngaphezulu kweenyanga ze-2. Amadoda ane-PPU futhi ngaphandle kwe-PPU ehlukile ezimpendulweni zawo eziqinile zokukhombisa ukubikezela izithombe ezingekho emthethweni kepha hhayi ezimpendulweni zawo ezithombeni ezivusa inkanuko. Izifundo ze-PPU uma ziqhathaniswa nezifundo zokulawula zikhombise ukwanda kokusebenza kwe-ventral striatum ngokukhethekile ezinkombeni ezibikezela izithombe ezingamaphutha kodwa hhayi izinhloso ezibikezela inzuzo yemali. Ukuzwela okuhlobene nezinkomba ezibikezela izithombe ezixakile vs izinzuzo zezimali zazihlobene kakhulu nesisusa sokuziphatha sokubuka izithombe ezingcolile (ezibonisa ukuthi 'bafuna' okungaphezulu), ubukhulu be-PPU, inani lokusebenzisa izithombe zocansi ngesonto, kanye nenombolo yokushaya indlwabu masonto onke. Ukuthola kwethu kusikisela ukuthi, kuyafana nalokho okubonwa ezintweni eziluthayo nokuluthwa ukugembula, izindlela zangaphakathi nezokuziphatha ezihambisana nokucutshungulwa okulindelwe kwezinkomba ezibikezela imivuzo engafanele ihlobene kakhulu nezici ezihambelana nomtholampilo ze-PPU. Lokhu okutholakele kusikisela ukuthi i-PPU ingahle imele umlutha wokuziphatha nokuthi ukungenelela okuwusizo ekuqondeni indlela yokuziphatha nokulutha kwezidakamizwa kufanele kuqinisekiswe ukuthi kufanele kuthathelwe indawo futhi kusetshenziswe ukusiza abesilisa abane-PPU.
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