Phambili. Behav. I-Neurosci. | doi: 10.3389 / fnbeh.2016.00154
Paula Banca1*, Valerie Voon2, 3 noNeil A. Harrison4
- 1Isikhungo Sokuziphatha Nezempilo Ne-Clinical Neuroscience, Inyuvesi yaseCambridge, United Kingdom
- 2UMnyango Wezengqondo, Inyuvesi yaseCambridge, e-United Kingdom
- 3ICambridgeshire nePeterborough NHS Foundation Trust, e-United Kingdom
- 4IBrighton neSussex Medical School, eNyuvesi yaseSussex, e-United Kingdom
Ukuzivumelanisa nezimo zokuziphatha kuyadingeka ekuzulazuleni ngempumelelo kwendawo eguqukayo njalo. Ukuphazamiseka kokuguquguquka kokuziphatha kuvame ukubonwa ekuphazamisekeni kwengqondo kubandakanya nalokhu okulutha. Lolu cwaningo luphenya ngezici ezimbili ezihlukile zokuphoqelela, okungukuthi ukufunda okuguqukayo kanye nokushintshwa kokugxila kokuqondisa, ukubeka okukhona kwe-orbitofrontal kanye nezindawo zangaphambili ezilandelanayo ngokulandelana, ekuphazamiseni kwemivuzo eyisisekelo neyesibili. Izifundo ezincisha ngokweqile futhi ngaphandle kokuzidla ngokungadingeki (i-BED), abantu abanokuziphatha okucindezelayo kocansi (CSB), i-alcohol alcohol disorder (AUD) kanye ne-pathological video-gaming (VG) bahlolwe ngemisebenzi emibili esekhompyutheni: i-Probabilistic Reversal Task (izivivinyo eziya kusihlokwana namaphutha wokuwina / okulahleka kokushintshwa) kanye ne-Intra / Extra-dimensional Set Shift Task (IED). Abantu abane-AUD nemidlalo yokudlala ama-video babehamba kancane ekufundeni okuguqukayo kungakhathalekile ngobuhle, ngezihloko ze-AUD zingabekezela ngemuva kokulahleka. Uma kuqhathaniswa nezifundo ezinamafutha amaningi ngaphandle kwe-BED, izifundo ze-BED zazimbi kakhulu ekufundeni okushintshashintshayo kodwa zibe ngcono ekulahlekelweni okuqokomisa imiphumela ye-valence njengomsebenzi wokudla kokuzidla. Izifundo ze-CSB zikhombise ukuzwela okuthuthukile kokuvuza imiphumela ngokutholwa okusheshayo nokubekezela okukhulu ngemivuzo ephezulu kakhulu. Siphinde sikhombise ukungahambi kahle ekushintsheni kokugxila kokushintshana kwabantu abane-BED ne-AUD okuhlobene namavolontiya anempilo. Lolu cwaningo luhlinzeka ngobufakazi bokufana kanye nokwehlukana ngezindlela ezimbili ezihlukene zokuziphatha kokuguquguquka kokuphazamiseka kwezimpawu zokuphoqelelwa. Lolu cwaningo luhlinzeka ngobufakazi bokufana kanye nokwehlukana ngezindlela ezimbili ezihlukene zokuziphatha kokuguquguquka kokuphazamiseka kwezimpawu zokuphoqelelwa. Sifingqa izifundo ngezifundo ezincishisiwe ngaphansi kwalaba bantu abagulayo. Sigcizelela ukufana ku-AUD naku-BED ngokulimazeka kunhlobonhlobo yezinhlobo zokuphoqelela, mhlawumbe okusekela ukudla kokuzidla njengezindlela zokulutha. Siphinde sigcizelele okujwayelekile ekufundeni okuguqukayo kuzo zonke iziphazamiso kanye neqhaza elibalulekile lemiphumela ebuhlungu. Lokhu okutholakele kugqamisa iqhaza lokungaguquki kokuziphatha kanye nokuphoqelela njengesizinda esifanele ekuchazeni ubukhulu bezengqondo nokukhonjwa kwe-endophenotypes efanelekile njengezinkomba zokuguquguqulwa kwezokwelapha.
Amagama angukhiye: Umlutha, ukuxhomekeka kotshwala, Ukuphazamiseka kwe-Binge Eating, ukukhuthazeka, ukubuyela emuva ekufundeni, ukuguquguquka.
Ukuqashelwa: iBanca P, i-Voon V neHarrison NA (2016). Ukuphoqeka kuyo yonke indlela yokusebenzisa kabi izidakamizwa nemivuzo engeyona yezidakamizwa. Ngaphambili. Behav. I-Neurosci. 10: 154. doi: 10.3389 / fnbeh.2016.00154
Kwamukelwe: 14 Apr 2016; Kwamukelwe: 19 Jul 2016.
Kuhlelwe ngu: I-Brand Matthias, ENyuvesi yaseDuisburg, eJalimane
Review yenziwe ngu:
Alicia Izquierdo, University of California, Los Angeles, USA
UJuan M. Dominguez, University of Texas e-Austin, e-USA
Rudolf Stark, University of Giessen, eJalimane
* Imibhalo: Dr. Paula Banca, University of Cambridge, Behavioural and Clinical Neuroscience Institute, eCambridge, e-United Kingdom, [i-imeyili ivikelwe]
UKUQALA
Izifundo ze-CSB zikhombise ukuzwela okuthuthukile kokuvuza imiphumela ngokutholwa okusheshayo nokubekezela okukhulu ngemivuzo ephezulu
IZIPHUMA
Izindlela eziya endaweni yokuhlunga: Esigabeni sokubuyela emuva ezifundweni ze-CSB (N = 25) ngokuqhathaniswa namavolontiya anempilo (N = 50) awukho umphumela omkhulu weGroup (F (1,73) = 1.33, p = 0.253), uValence (F (1,73) = 1.47, p = 0.229) noma umphumela wokusebenzisana (F (1,73) = 0.008, p = 0.928) (Umdwebo 1). Esigabeni se-Acquisition kwizifundo ze-CSB (Umvuzo: HV 9.39 (SD 7.34); CSB 6.39 (SD 5.43); Loss: HV 7.26 (SD 6.53); CSB 8.69 (SD 7.83) kulikuwa nokusebenzisana kweGroup x Valence (F (1,73) = 4.35, p = 0.039) lapho izihloko ze-CSB zazishesha ukufunda eMiklomelweni futhi zahamba kancane zifunde ekulahlekelweni ngokuqhathaniswa namavolontiya anempilo. Kwakungekho iqembu (F (1,73) = 0.38, p = 0.539) noma umphumela weValence (F (1,73) <0.001, p = 0.983 Win-Stay / Lose-Shift: Kuhlaziyo lwe-Lose-Shift, lapho kwakuwumphumela weQembu x Valence (Ithebula 3; Umdwebo 2); ekuhlaziyweni kwe-posthoc, izifundo ze-CSB zazine-Lose-Shift ephansi noma zazinethuba lokuhlala noma ziphikelele ngemuva kokulahlekelwa esimweni somvuzo 422 Ukulahleka (p = 0.005) neNeutral (p <0.001). Ngokufanayo, ekuhlaziyweni kweWin-Stay, kube nomphumela weQembu x Valence; ekuhlaziyweni kwe-posthoc, i-CSB yayine-Win-Stay ephakeme noma yayinamathuba amaningi okuhlala ngemuva kokuwina esimweni Somvuzo ngokuhlobene nokulahlekelwa (p = 0.019) no-Neutral (p = 0.007). 427
Isifingqo: Izifundo ze-CSB zazishesha ukufunda emvuzweni wesigaba sokutholwa uma ziqhathaniswa namavolontiya anempilo futhi kungenzeka ukuthi zikhuthazele noma zihlale ngemuva kokulahleka noma ukunqoba esimweni seMvuzo.
UKUKHULUMA
Izincwadi zihlala zinezici ezihlukile zokujikeleza kwe-fronto-striatal ekufundeni okuguqukayo nasekuguqukeni kokunakwa, okuyi-orbitof Pambal kanye ne-lateral preortalcortices ngokulandelana. Sike sabika ngaphambilini ngalezi zinyathelo zokubuyela emuva kokufunda (inani lezilingo eziya ku-criterion) nokushintshwa kwe-ED okubonisa ubudlelwano phakathi kwezijikelezo ze-fronto-striatal circsocial (Morris et al., 2016).
Ngokuqhathanisa nokunye ukuphazamiseka, i-CSB ngokuqhathaniswa namavolontiya anempilo akhombise ukutholwa okusheshayo ukuvuza imiphumela kanye nokukhuthazela okukhulu esimweni somvuzo kungakhathalekile mphumela. Izifundo ze-CSB azikhombisanga noma yikuphi ukuthikamezeka kokusetha kokushintsha noma kokufunda emuva. Lokhu okutholakele kuhlangana nokutholwe kwethu kwangaphambilini kokuncamelayo okuthuthukisiwe okuvezwe emiphumeleni yezocansi noma yemali, kuphakamisa ukuzwela okuthuthukile kwemivuzo (Banca et al., 2016). Kuqhutshwa ezinye izifundo ezisebenzisa imivuzo ephambili. Ukushoda ekuqondisweni okuqondiswe egomeni noma ekuhloleni kwe-CSB akukaze kubikwe.
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