I-Neuropsychopharmacology. 2018 Oct 6. i-doi: 10.1038 / s41386-018-0235-1.
Kuiper LB1, I-Beloate LN1, I-Dupuy BM1, Coolen LM2,3.
abstract
Ukulimala ukuhlakulela ukulutha kuyathonywa yizinto eziningi, kufaka phakathi ukuziphatha komphakathi. Ngokuqondile, kubasebenzisi babantu, ukuthatha izidakamizwa kumongo womphakathi nezomzimba kubonakala kuthuthukisa ukuziphatha okuqhubekayo kwezidakamizwa. Abasebenzisi babika injabulo yocansi ephakanyisiwe njengesizathu sokusebenzisa ezinye izidakamizwa nokubonisa ukuziphatha ngengozi ngisho nalapho bevivinywa kuhulumeni ongenazidakamizwa. Lapha, usebenzisa imodeli yokunqanda ukuzisebenzisa ngokweqile kwamagciwane, i-hypothesis ihlolwe ukuthi i-methamphetamine (i-Meth)-eyenzeka ngokufanayo nangomsebenzi wezenhlalo nezomuntu wokwenza ucansi kwandisa ubungozi bokulutha. Amantombazane ama-Sprague Dawley ayehlala emphakathini futhi abe nemingcele yokufinyelela okulinganiselwe iMeth self-administration (esiphezulu i-1 mg / kg / iseshini). Ukuthatha i-Meth kungaba okufanayo noma okungavumelani nokuziphatha ngokocansi: izilwane ezifanayo zathandwa ngumfazi osamukelayo emva kwesikhatsi ngasinye, kanti izilwane ezingezona ezifanayo zithole isipiliyoni esifanayo socansi ngesonto langaphambili. Okulandelayo, ukuziphatha okufuna izidakamizwa kwalinganiswa ngesikhathi sokucubungula, ukuqedwa, nokubuyiselwa kweseshini ngokusebenzisa izinhlelo zokuqedwa nokubuyisela okuhlukile kwizifundo ezihlukene ze-4. Womabili amaqembu azuza ngokulingana uMeth self-administration futhi akazange ahluke ekutheni u-Meth adle. Kodwa-ke, ukuziphatha okufuna izidakamizwa kwakungaphezulu kakhulu kwezilwane ngesikhathi esifanayo ngesikhathi sokusebenza kwemisebenzi yokuqeda, ukudiliza, nokuqapha noma ukuhlolwa kwe-Meth-reinduced incestation. Ngaphezu kwalokho, ukuziphatha ngokobulili ngokungabikho kweMeth kwabangela ukubuyiselwa kwezidakamizwa ezilwaneni ezifanayo. Le miphumela ibonisa ukuthi ukuthatha i-Meth esimweni somphakathi nesocansi kukhulisa kakhulu ukuhlukunyezwa kwezidakamizwa zamantombazane. Leli gama elizimele lokuzilawula izidakamizwa ngokufanayo kanye nokuziphatha komphakathi nokuziphatha ngokobulili inikeza imodeli ewusizo yokutadisha i-neurobiology engezansi yokusukela ekuhlaselweni komphakathi ekubhekaneni nezidakamizwa.
I-PMID: 30337639
I-DOI: 10.1038/s41386-018-0235-1
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