IZIMBANGELA: Imibono yokuluthwa kanye nokuphazamiseka kokulawula okufakayo iyashintsha njengoba kukhonjiswe ku-11th inguqulo ye-International Classization of Disriers (ICD-11, WHO, 2018). Kodwa-ke, izifundo ezigxila ekuqhathaniseni okuqondile kokwehluka kobuchopho obuhlelekile ekuziphatheni nasezintweni eziluthayo izidakamizwa kukhawulelwe.
AIM: Lapha siqhathanisa ama-grey ndaba amavolumu (ama-GMVs) emaqenjini abantu abanokuphazamiseka kokuziphatha kocansi okucindezelayo (CSBD), ukugembula (GD), kanye ne-drug use disorder (AUD) nalabo abangenakho kwalokhu kuphazamiseka (abahlanganyeli abalawula kahle ama-HCs).
IZINDLELA: I-Voxel-based morphometry (VBM) yaqashwa ukutadisha ukwakheka kobuchopho kanye nokuhlolwa kwezimpawu zokuluthwa kwahlolwa ngemibuzo. Ukuhlonza izifunda zobuchopho ezihlobene nobunzima bokulutha, kwahlanganiswa ukuxhumana phakathi kwezikolo zemibuzo nama-GMV.
IMINININGWANE YOKUQHAWULA: Siqoqe imininingwane ye-MRI (GMVs) evela ezigulini ezingama-26 ze-CSBD, iziguli ezingama-26 ze-GD, iziguli ezingama-21 ze-AUD nababambiqhaza abangama-25 be-HC (bonke abesilisa abanobungqingili; iminyaka: 24-60; M = 34.5, SD = 6.48).
IMIPHUMELA: Abantu abathintekile (CSBD, GD, AUD) ngokuqhathaniswa nabahlanganyeli be-HC bakhombise ama-GMV amancane esigxotsheni sobungakwesobunxele, ikakhulukazi ku-cortex ye-orbitofrontal. Umehluko oshiwo kakhulu wabonwa emaqenjini e-GD ne-AUD, kanye ne okungenani eqenjini le-CSBD. Kube nokuhlobana okungekuhle phakathi kwama-GMVs kanye nobunzima bokuphazamiseka eqenjini le-CSBD. Ukwehla okuphakeme kwezimpawu ze-CSBD kwaxhunyaniswa nokuncipha kwe-GMV ku-anterior cingulate gyrus efanele.
IMIBUZO YOKUKHULULEKILE: Ukuthola kwethu kusikisela ukufana phakathi kokukhubazeka okuthile kokulawula ukuthinteka kanye nemilutha.
AMA-STRENGTHS KANYE NOKUGULA Kepha lolu cwaningo belunqunyelwe abesilisa nabesilisa abathandanayo kuphela. Izifundo ezinde
IMIBUZO: Ukucwaninga kwethu kudlulisa ukutholwa kwangaphambi kokuphazamiseka kokusetshenziswa kwezidakamizwa kwe-GMV ephansi kuqala emithonjeni yangaphambi kwe-cortical cortical phakathi kwamaqembu ama-3 emitholampilo eziguli ngokulawulwa okuqondile kokuziphatha kanye nokuphazamiseka kokuziphatha nezidakamizwa. Ukuxhunyaniswa okungekuhle phakathi kwama-GMVs kanye nezimpawu ze-CSBD kanye ne-anterior cingrate gyrus kusikisela ukuxhumana ngokuxhunyaniswa kwezimpawu zesifo somtholampilo.
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