UJokinen, uJussi
Umeå University, i-Faculty of Medicine, uMnyango Wezesayensi Yezempilo.ORCID iD: 0000-0001-6766-7983
UFlangan, uJohn
UChatzittofis, u-Andreas
Umeå University, i-Institute of Medicine, uMnyango Wezesayensi Yemitholampilo.
U-Öberg, uKatarina
Abstract [en]
Ingemuva: Isifo se-Hypersexual (HD) esihlanganisa izici ze-pathophysiological njengokuncishiswa kwesifiso sobulili, ukuluthwa ngokocansi, ukungabi namandla kanye nokuphoqeleka kwaphakanyiswa njengokuxilongwa kwe-DSM-5. "Ukucindezelwa Kokuziphatha Ngokobulili Okuphoqelekile" manje sekuvezwa njengesifo esilawula umfutho ku-ICD-11. Izifundo zakamuva zikhombise ukungahambisani kahle kwe-HPA axis emadodeni ane-HD. I-Oxytocin (OXT) ithinta ukusebenza kwe-eksisi ye-HPA; azikho izifundo ezihlole amazinga we-OXT ezigulini ezine-HD. Ukuthi ukwelashwa kwe-CBT kwezimpawu ze-HD kunomthelela yini emazingeni we-OXT akukaphenywa.
Izindlela: Sihlole amazinga e-plasma OXT ezigulini ezingamadoda ezingama-64 ezine-HD kanye namavolontiya aneminyaka yobudala engama-38 afanayo. Ngaphezu kwalokho, sihlole ukuhlangana phakathi kwamazinga we-planethi we-OXT nezimpawu zobukhulu be-HD sisebenzisa isilinganiso sokulinganisa isenzo se-hypersexual yokuziphatha: I-Hypersexual disorder screening yokusungula (HDSI) kanye nesikali socansi oluphathelene nocansi (SCS). Ingxenye yeziguli (N = 30) iqedele uhlelo lwe-CBT olwenziwe ngeqembu olwenzelwe i-HDT futhi lwalunesilinganiso sesibili se-OXT ekwelashweni kwangemva kwalokho. I-OXT ilinganiswe neRadioimmunoassay (RIA).
Imiphumela: Iziguli ezine-HD zazinamazinga aphezulu kakhulu we-OXT (Asho ama-31.0 ± SD 9.9 pM) uma kuqhathaniswa namavolontiya anempilo (asho ukuthi i-16.9 ± SD 3.9 pM) (p <0.001). Kube khona ukuhlangana okuhle phakathi kwamazinga e-OXT nezikali zokulinganisa ezilinganisa ukusebenza kwe-hypersexual (Spearman rhos phakathi kwe-HDSI r = 0.649, p <0.001 ne-SCS r = 0.629, p <0.001) kubahlanganyeli besifundo abahlanganisiwe. Iziguli eziqede ukwelashwa kwe-CBT zanciphisa kakhulu amazinga we-OXT kusuka ekwelashweni kwangaphambili (30.5 ± 10.1pM) kuya ekwelashweni ngemuva (20.2 ± 8.0pM) (p <0.001). Iziguli ezine-HD zazinokuhlangana okuhle okuhle kwezinguquko zazo ku-HD: I-CAS enezinga le-plasma oxytocin ngaphambi nangemva kwe-CBT (r = 0.388, p value = 0.0344).
Iziphetho: Imiphumela iphakamisa uhlelo lwe-oxytonergic hyperactive kwiziguli zesilisa ezine-hypersexual disorder okungaba yindlela yokuthola amandla ukuthola uhlelo lokuxineka kwe-hyperactive. Ukwelashwa kweqembu le-CBT okuphumelelayo kungaba nomthelela ohlelweni lwe-oxytonergic system.
Indawo, umshicileli, unyaka, uhlelo, amakhasi
I -velo Publishing Group, 2019 Vol. 44, k. 114-114
Amagama angukhiye [en]
I-Oxetocin ne-Addiction, Hypersexual Disorder, i-Cognitive Behaeve Therapy
Isigaba sikazwelonke
I-Pharmacology and Toxicology Neuroscience Psychiatry
Izikhombi
I-URN: urn: nbn: se: umu: diva-168967I-ISI: 000509665600228I-OAI: oai: DiVA.org: umu-168967DiVA, id: diva2: 1420877
Inkomfa
Umhlangano Waminyaka Yonke Wama-58 we-American-College-of-Neuropsychopharmacology (ACNP), DEC 08-11, 2019, Orlando, FL
Isengezo: 1
Umhlangano Abstract: M71
Itholakala kusuka: 2020-04-01 Yakhiwe: 2020-04-01 Igcine ukubuyekezwa: 2020-04-01
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