I-Neuropsychopharmacology. I-2017 Jan 4. doi: 10.1038 / npp.2017.1.
Kuiper LB1,2, Frohmader KS3,4, Coolen LM1,3,4.
abstract
Ukusetshenziswa kwama-psychostimulants kuvame ukuhlotshaniswa ne-hypersexourse, futhi abasebenzisi be-psychostimulant bakhombe imiphumela yezidakamizwa ekuziphatheni kobulili njengesizathu sokusetshenziswa okwengeziwe. Kwakhonjiswa phambilini ukuthi i-methamphetamine (Meth), lapho ihanjiswa kanye kanye nokuziphatha kobulili kukhombisa ukungahambi kahle kokuvinjwa kokuziphatha kobulili ocansini olunenkinga yokuya ocansini (CSA) lapho ukuhambisana kuhambisana nokugula. Lokhu kukhombisa ukungaziphathi kahle kwezocansi okulandela iMeth kanye nesipiliyoni sobulili.
Ucwaningo olukhona manje luhlolisise izindlela ze-neural ezenziwe ngesikhathi sokuvinjwa kokuziphatha kobulili kanye nemiphumela ye-Meth kanye nokuziphatha kobulili kokusebenza kwe-neural kulezi zindlela, kusetshenziswa i-ERK phosphorylation (pERK) njengophawu lomsebenzi we-neural.
Okokuqala, ukuvezwa kwesisusa sokubuyela emuva esimeni esihle kwabesilisa abaqeqeshelwe ukuvimbela ukuziphatha kobulili ku-CSA paradigm kuboniswe ukukhulisa ukubonakaliswa kwe-PERK ku-medial preaphambilial (mPFC), orbitofrontal cortex (OFC) nezindawo ezise-striatum nase-amygdala.
Okwesibili, imiphumela ye-Meth Meth kanye nezocansi yavivinywa emadodeni atholakala engxenyeni yansuku zonke ye-4 nsuku zonke ye-Meth (1 mg / kg) noma i-saline and mating futhi yavezwa ku-CSA ngesonto elilodwa ngemuva kokwelashwa kokugcina. Amadoda aphethwe yi-Meth kanye ne-mating akhombisa ukuphazamiseka okukhulu ekuvinjelweni kokuphola, ukuphakama kwenkulumo ye-PERK ngaphansi kwezimo zesisekelo, futhi kuphazamise ukungena kwe-PERK ngokuchayeka kwisimo esinamandla sokuphikisa ku-mPFC ne-OFC.
Ukuguqulwa kwe-pERK bekuku-CaMKII-expression neurons, kuphakamisa ushintsho kumiklamo yalezi zindawo. Ngokubambisana, le mininingwane ikhombisa ukuthi iMeth kanye kanye nokuhlangenwe nakho ngesikhathi esisodwa kubangela ukuthi kube nokuziphatha okubi ngokobulili okuhambisana nezinguquko ekusebenzeni kwe-neural ku-mPFC ne-OFC.
I-PMID: 28051103
I-DOI: I-10.1038 / npp.2017.1
;