Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling (2005)

Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1737–1742. Published online 2005 January 21. doi:  10.1073/pnas.0409456102 PMCID: PMC547862 Neuroscience Satoru Takahashi,* Toshio Ohshima,† Andrew Cho,‡ Taduru Sreenath,*‡ Michael J. Iadarola,§ Harish C. Pant,¶ Yong Kim,∥ Angus C. Nairn,∥** Roscoe O. Brady,†† Paul Greengard,∥ and Ashok B. Kulkarni*‡‡‡ Author information ► Copyright and […]

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Dopamine signaling in food addiction: role of dopamine D2 receptors (2013)

FULL STUDY – PDF BMB Rep. 2013 Nov;46(11):519-26. Baik JH. Author information Abstract Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are widely believed to modify reward-related behaviors and are therefore closely associated with drug addiction. Recent evidence now suggests that as with drug […]

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Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling (2013)

Comments: Appears to show that Cdk5 causes down regulation of dopamine D2 receptors. Amazingly, translation factor deltafosb induces the production of Cdk5. Jeong J, Park Y-U, Kim D-K, Lee S, Kwak Y, et al. (2013) PLoS ONE 8(12): e84482. doi:10.1371/journal.pone.0084482 Abstract The dopamine D2 receptor (DRD2) is a key receptor that mediates dopamine-associated brain functions […]

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“Spermatorrhea” resources

Post from Nofap Firstly, I want to thank and congradulate each and every one of you guys and gals for having the courage to take up this challenge, and special thanks to Gary Wilson, the moderator of “yourbrainonporn” for his hard work and reasearch on the subject. Note that English is not my first language […]

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Need porn diet for three to five months to get an erection again, Alexandra Katehakis MFT, CSAT-S

LINK TO ARTICLE – ‘Youth and Pornography Addiction’ (The Fix) Young viewers are unintentionally training their bodies to become aroused by the unique conditions provided by internet pornography, explained Katehakis, who is also a certified sex addiction therapist and clinical director of the Center for Healthy Sex in Los Angeles. “What happens is when these […]

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‘Youth and Pornography Addiction’ (The Fix)

Letting teens get their quick fix of sex on the net could cause long-term physiological and psychological damage. Men younger than ever are reporting difficulty achieving intimacy in relationships and are struggling well into adulthood to regain normal sexual function, according to sex addiction experts. High-speed Internet pornography, more specifically the addiction to seeking novel […]

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