Am J Psychiatry. 2009 Jun;166(6):702-10. doi: 10.1176/appi.ajp.2008.08081201. Epub 2009 May 1. Pizzagalli DA, Holmes AJ, Dillon DG, Goetz EL, Birk JL, Bogdan R, Dougherty DD, Iosifescu DV, Rauch SL, Fava M. Source Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St., Cambridge, MA 02138, USA. [email protected] OBJECTIVE: Major depressive disorder is characterized […]
Read More… from Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder (2009)
John D. Salamone, Mercè Correa Neuron – 8 November 2012 (Vol. 76, Issue 3, pp. 470-485) Summary Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional […]
Read More… from The Mysterious Motivational Functions of Mesolimbic Dopamine (2012)
Neuroimage. 2009 May 15;46(1):327-37. doi: 10.1016/j.neuroimage.2009.01.058. Epub 2009 Feb 6. Jan Wacker,1,2 Daniel G. Dillon,2 and Diego A. Pizzagalli2 Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Neuroimage See other articles in PMC that cite the published article. Go to: Abstract Anhedonia, the reduced […]
Read More… from The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009)
500 days ago during my 31st year, started my NoFap journey. I was having some ED issues,. Without knowing about r/NoFap, I went 7 days without fapping. ED was a little better. I looked to the web for answers. I came across the site YourBrainOnPorn. It led me here. I never got into weird UltraPorn, […]
Read More… from Age 32 – 500 days: erectile dysfunction
I wanna start with how I am so blessed to find www.yourbrainrebalanced.com. So many things in my life would not be as good as they are now. Anyways, to be honest I did not start a clock counter but I have definitely surpassed 90 days and am somewhere in the 100’s. I started this reboot […]
Read More… from Age 17 – HOCD & porn-induced ED
So in only twice in my life I have had this feeling before. The first time, when I relapsed it was back in April was during my biggest reboot (40 days), since then I haven’t felt that way…until two days ago! I am feeling that passion for life again, for only the second time in […]
Read More… from Age 25 – Erections, Fire, Passion, Libido, LIFE is BACK BABY!
The first time I had ever heard about NF was when a redditor friend of mine showed me this page he had randomly stumbled upon. My reaction was to admit “oh, man I could never do that”, while secretly wishing I could. For months before NF, I had been trying to quit continuously, but never […]
Read More… from Age 26 – 500 days: I’m finally in a relationship unlike any I’ve ever been
I am writing this on Day 60 of my reboot process, following my worst relapse yet. Sharing what I’ve learned. Please let me know if you find anything useful or if you can relate to anything. Apologies for the rambling. On Relapsing: On a good day, the idea of relapsing seems impossible. I feel that […]
Read More… from Reflections at 60 days – On relapsing, habit, guilt. obsessive thoughts, and getting help.
J Neurosci. 2006 May 10;26(19):5131-42. Ulery PG, Rudenko G, Nestler EJ. Source Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA. Abstract The transcription factor DeltaFosB (also referred to as FosB2 or FosB[short form]) is an important mediator of the long-term plasticity induced in brain by […]
Read More… from Regulation of DeltaFosB stability by phosphorylation (2006)
Brain Res. 2010 May 6; 1329: 10–20. Published online 2010 March 11. doi: 10.1016/j.brainres.2010.02.081 PMCID: PMC2876727 John F. Enwright, III,1 Megan Wald,1 Madison Paddock,1 Elizabeth Hoffman,1 Rachel Arey,2 Scott Edwards,2 Sade Spencer,2 Eric J. Nestler,3 and Colleen A. McClung2,* Author information ► Copyright and License information ► The publisher’s final edited version of this article […]
Read More… from DeltaFosB indirectly regulates Cck promoter activity (2010)